Protein tyrosine phosphatase 1B and its effects on pancritic ß cell functions: Research advances / 国际药学研究杂志

Tyrosine phosphorylation, a key post-translational mechanism, is necessary for metabolic homeostasis. Protein tyrsine phosphatase 1B(PTP1B), the main negative regulator in insulin signaling pathway, is becoming a potential target for the treatment of type 2 diabetes mellitus and related metabolic diseases. In thin paper, the structural properties of PTP1B and its regulation on the mass, insulin secretion, endoplasmic reticulum ER stress and inflammation in pancreatic ß cells are reviewed. It is indicated that PTP1B inhibition is important for the protection of ß cells and the treatment of type 2 diabetes mellitus.