Surgical treatment for stress urinary incontinence in women: A systematic review and meta-analysis / Tratamento cirúrgico da incontinência urinária de esforço em mulheres: revisão sistemática e metanálise

Abstract Objective To compare surgical treatments for stress urinary incontinence in terms of efficiency and complications. Data Sources We searched the MEDLINE and COCHRANE databases using the terms stress urinary incontinence, surgical treatment for stress urinary incontinence and sling. Selection of Studies Forty-eight studies were selected, which amounted to a total of 6,881 patients with scores equal to or higher than 3 in the Jadad scale. Data Collection Each study was read by one of the authors, added to a standardized table and checked by a second author. We extracted data on intervention details, follow-up time, the results of treatment and adverse events. Data Synthesis Comparing retropubic versus transobturator slings, the former was superior for both objective (odds ratio [OR], 1.27; 95% confidence interval [CI], 1.05-1.54) and subjective (OR, 1.23; 95% CI, 1.02-1.48) cures. Between minislings versus other slings, there was a difference favoring other slings for subjective cure (OR, 0.58; 95% CI, 0.39- 0.86). Between pubovaginal sling versus Burch surgery, there was a difference for both objective (OR, 2.04; 95% CI, 1.50-2.77) and subjective (OR, 1.64; 95% CI, 1.10-2.44) cures, favoring pubovaginal sling. Therewas no difference in the groups: midurethral slings versus Burch, pubovaginal sling versus midurethral slings, transobturator slings, minislings versus other slings (objective cure). Retropubic and pubovaginal slings are more retentionist. Retropubic slings have more bladder perforation, and transobturator slings, more leg and groin pain, neurological lesion and vaginal perforation. Conclusion Pubovaginal slings are superior to Burch colposuspension surgery but exhibit more retention. Retropubic slings are superior to transobturator slings, with more adverse events. Other slings are superior to minislings in the subjective aspect. There was no difference in the comparisons between midurethral slings versus Burch colposuspension surgery, pubovaginal versus midurethral slings, and inside-out versus outside-in transobturator slings.

Resumo Objetivo comparar tratamentos cirúrgicos para incontinência urinária de esforço (IUE), quanto à eficiência e complicações, por meio de revisão sistemática seguida de metanálise. Fonte dos dados Fizemos busca nas bases de dados MEDLINE e COCHRANE, utilizando os termos stress urinary incontinence, surgical treatment for stress urinary incontinence e sling. Seleção dos estudos Selecionamos 48 estudos, totalizando 6.881 pacientes com pontuação igual ou maior do que 3 na escala de Jadad. Coleta de dados Cada estudo foi lido por um autor, colocado em tabela, e checado por outro autor. Extraímos dados como detalhes das intervenções, tempo de seguimento, resultados do tratamento e eventos adversos. Síntese dos dados Não houve diferença nas comparações: sling de uretra média versus cirurgia de Burch, quanto às curas objetiva (razão de chances [RC]: 1,29; intervalo de confiança de 95% [IC95%]: 0,76-2,20) e subjetiva (RC: 1,16; IC95%: 0,67- 2,00); sling de uretramédia transobturatório outside-in versus inside-out quanto às curas objetiva (RC: 0,78; IC95%: 0,45-1,35) e subjetiva (RC: 0,83; IC95%: 0,58-1,18); sling pubovaginal e de uretra média quanto à cura objetiva (RC: 1,64; IC 95%: 0,52-5,15). Comparando sling retropúbico comtransobturatório, o retropúbico foi superior quanto às curas objetiva (RC: 1,27; IC95%: 1,05-1,54) e subjetiva (RC: 1,23; IC95%: 1,02-1,48). Entre minislings e outros slings, houve diferença favorável a outros slings quanto à cura subjetiva (RC: 0,58; IC95%: 0,39-0,86) mas não quanto à cura objetiva (RC: 0,72; IC95%: 0,47-1,10). No grupo sling pubovaginal e Burch, houve diferença quanto à cura objetiva (RC: 2,04; IC95%: 1,50-2,77) e subjetiva (RC: 1,64; IC95%: 1,10-2,44). Slings de uretra média apresentam mais erosão, enquanto a cirurgia de Burch tem mais complicações na ferida operatória e infecção do trato urinário. Slings retropúbicos e pubovaginais sãomais retencionistas. Slings retropúbicos estãomais associados a lesão vascular, hematomas e perfuração vesical, e transobturatórios, à dor na perna e virilha, lesão neurológica e perfuração vaginal. Conclusão Slings pubovaginais são superiores à cirurgia de Burch, porém mais retencionistas. Slings retropúbicos são superiores aos transobturatórios, embora tenham mais eventos adversos. Outros slings são superiores aos minislings em relação ao aspecto subjetivo. Não houve diferença nas comparações entre slings de uretra média e cirurgia de Burch, slings pubovaginais, transobturatórios inside-out e inside-in.

Female Prostate? - Clear Cell Adenocarcinoma of Female Urethra

Clear cell adenocarcinoma of the female urethra is extremely rare. Because the primary urethral carcinomas are rare, standard diagnostic algorism and management has not been established yet. We report a case of clear cell adenocarcinoma of the proximal urethra in a 76-year-old female. She was presented with voiding difficulty for several years after pubovaginal sling operation due to stress urinary incontinence twelve years ago. Before this period, she had managed with medication for detrusor hypocontractility. Recently she complained bloody vaginal discharge, and her vaginal examination revealed palpable mass on the anterior vaginal wall. Pelvic MRI showed a 5×4.5cm sized tumor surrounding the proximal urethra which was mimicking prostate with no lymphadenopathy. Biopsy of the mass confirmed it to be clear cell adenocarcinoma. She underwent anterior pelvic exenteration and ileal conduit with bilateral pelvic lymph node dissection. The patient received adjuvant radiotherapy and chemotherapy as treatment. We should carefully evaluate patients with voiding symptom after anti-incontinence surgery and multimodal treatment should be applied for locally advanced urethral carcinoma.

Sling uretral pubovaginal e cirurgia de controle de danos / Pubovaginal sling urethral and surgery damage control

O sling pubovaginal tem sido empregado no tratamento da incontinência urinária de esforço, tanto do tipo deficiência esfincteriana intrínseca como dos tipos anatômica e associada. Complicações ao procedimento são frequentes, porém, simples e transitórias. Os autores relatam um caso de lesão de vasos pélvicos transoperatória (sling pubovaginal), sendo necessária a cirurgia de controle de danos.

The pubovaginal sling is currently being used not only for stress urinary incontinence (SUI) type III as well as for we other types of SUI. The complications are frequent, in general not serious and transitory. The authors report the case of bleeding venous origin, from the fossa of the obturator nerve, the iliac plexus and presacral plexus and necessary the damage control.

Long Term Results of Pubovaginal Sling Procedure Based on Anchoring Sites of Suture Material / 대한비뇨기과학회지

PURPOSE: The long term results of a pubovaginal sling procedure were assessed in females with stress urinary incontinence (SUI), and the safety and efficacy, between the Cooper's ligament anchoring and the abdominal wall anchoring of the suture material, compared. MATERIALS AND METHODS: Fifteen, and 20, women underwent a pubovaginal sling procedure, with abdominal wall anchoring (group I), or with Cooper's ligament anchoring (group II), respectively. The surgical outcomes, the satisfaction of patients and the complications were assessed by a questionnaire. RESULTS: In groups I and II the mean follow-ups were 58.1 (range 43-71) and 42.5 (range 36-50) months, respectively. Thirteen (86.6%) and 1 (6.7%), and 17 (85.0%) and 2 (10.0%) of the patients in groups I, and II, were cured and improved, respectively. No statistical difference in the self-reported satisfaction scores was shown between the two groups. The duration of the hospital stay and residual urine less than 50ml were significantly lower in group II (p<0.01). No permanent urinary retention or de novo urge incontinence occurred, but the postoperative urgency remained at 50.0% in both groups. CONCLUSIONS: According to our long term follow-up, the pubovaginal sling procedure is a highly effective and safe surgery for SUI, without urge incontinence. The modified technique, of a pubovaginal sling procedure, with anchoring of the fascia at the Cooper's ligament, is an alternative treatment for SUI, with a low complication rate.

Comparison of Burch Colposuspension, Pubovaginal Sling Operation and Tension-Free Vaginal Tape for Surgical Treatment of Stress Urinary Incontinence In Women / 대한산부인과학회잡지

OBJECTIVE: The object of this study was to compare the cure rate and confirm the clinical efficacy of three most frequent surgical procedures for stress urinary incontinence (Burch colposuspension, pubovaginal sling operation, tension-free vaginal tape). MATERIALS AND METHODS: We collected datas from the records of ninety-one patients who were diagnosed as stress urinary incontinence from Jan. 1999 to May 2001. Burch colposuspension was performed by department of gynecology, Severance hospital in thirty-three patients, pubovaginal sling operation was performed by department of urology in twenty-eight patients, and tension-free vaginal tape was performed by department of urology in thirty-one patients. We investigated the characteristics of patients, preoperative urodynamic study results, cure rates and complication rates for the result, and compared them by x2-test. RESULTS: There were statistically no significant differences between the cure rate of each operation after 3, 6 month of operation but after 12 months of follow up, the cure rate of pubovaginal sling operation was significantly higher than that of Burch operation and tension-free vaginal tape. CONCLUSION: The cure rate of pubovaginal sling operation was significantly higher after 12 months of follow up after surgery. There was no significant difference between cure rates of Burch operation and tension- free vaginal tape. We propose randomized prospective study with larger population in the future.

Autologous Pubovaginal Fascial Sling for Female Anatomical Incontinence: Success Rate and Risk Factors / 대한비뇨기과학회지

PURPOSE: Because of the disappointing long-term results of transvaginal bladder neck suspension surgery for anatomical incontinence (AI), a pubovaginal sling, which was formerly operated for sphincteric incontinence (SI), was used to treat AI. The results of the pubovaginal sling for treating AI and the risk factors that affect the result were evaluated. MATERIALS AND MTHODS: A total 39 women with AI underwent a pubovaginal fascial sling using a strip of autologous rectus muscle fascia. The urethral sphincteric function was assessed by measuring the Valsalva leak point pressure. Fifteen patients has type I and 24 patients type II stress incontinence. The results of the pubovaginal sling were compared with those of 51 women who received the Raz precedure. The risk factors for the pubovaginal fascial sling were evaluated. RESULTS: The success rate of an autologous pubovaginal sling (95.6%) at mean follow-up period of (21 months) was significantly higher than that of the Raz bladder neck suspension (80.4%) during the same follow-up period (p<0.05). The success rate of the Raz procedure - 80.4%, 70.8% and 60.7% at 21, 36, 72 months - was decreased after months. The predictive factors for the pubovaginal sling - the number of deliveries, history of hystectomy, the type of stress incontinence, cystocele, urge incontinence, and age - had no significant effect on the success rate of the pubovaginal sling (p<0.05). CONCLUSIONS: A pubovaginal fascial sling may be an effective surgical treatment not only for treating sphincteric incontinence but also anatomical incontinence.

Autologous Pubovaginal Fascial Sling for Female Anatomical Incontinence: Success Rate and Risk Factors / 대한비뇨기과학회지

PURPOSE: Because of the disappointing long-term results of transvaginal bladder neck suspension surgery for anatomical incontinence (AI), a pubovaginal sling, which was formerly operated for sphincteric incontinence (SI), was used to treat AI. The results of the pubovaginal sling for treating AI and the risk factors that affect the result were evaluated. MATERIALS AND MTHODS: A total 39 women with AI underwent a pubovaginal fascial sling using a strip of autologous rectus muscle fascia. The urethral sphincteric function was assessed by measuring the Valsalva leak point pressure. Fifteen patients has type I and 24 patients type II stress incontinence. The results of the pubovaginal sling were compared with those of 51 women who received the Raz precedure. The risk factors for the pubovaginal fascial sling were evaluated. RESULTS: The success rate of an autologous pubovaginal sling (95.6%) at mean follow-up period of (21 months) was significantly higher than that of the Raz bladder neck suspension (80.4%) during the same follow-up period (p<0.05). The success rate of the Raz procedure - 80.4%, 70.8% and 60.7% at 21, 36, 72 months - was decreased after months. The predictive factors for the pubovaginal sling - the number of deliveries, history of hystectomy, the type of stress incontinence, cystocele, urge incontinence, and age - had no significant effect on the success rate of the pubovaginal sling (p<0.05). CONCLUSIONS: A pubovaginal fascial sling may be an effective surgical treatment not only for treating sphincteric incontinence but also anatomical incontinence.

Pubovaginal Sling Operation Using Cadaveric Fascia Lata for the Female Stress Urinary Incontinence

PURPOSE: Pubovaginal sling operation has been main treatment procedure for female stress urinary incontinence. Allografts have been substituted for autografts as the material of pubovaginal sling operation to decrease postoperative morbidity, although to our knowledge their long-term durability is unknown. Therefore, we investigated the outcome and efficacy of pubovaginal sling operation using allograft cacaveric fascia lata. MATERIALS AND METHODS: From September 2000 to December 2001, 47 patients with stress urinary incontinence underwent pubovaginal sling operation using cadaveric fascia lata and had been followed up more than 10 months. Preoperative evaluation included medical history, physical examination, SEAPI score and urodynamic study including Abdominal leak point pressure (ALPP). All patients were assessed for the outcome of the procedure with subjective satisfaction by scores of SEAPI classification. RESULTS: With a mean follow-up of 18.2 months(range 10 to 25), urinary incontinence completely disappeared in 42 patients(89.4%), significantly improved in 4 patients(8.5%), not improve in 1 patient(2.1%). Marked improvement was shown in all patients according to the SEAPI score. Postoperative de novo urge incontinence was not found. Complication included suprapublic pain in 4 patients and transient urinary retention in 7 patients, but these were disappeared later in all patients. Operations with allograft fascia lata slings were tolerated, and neither infection nor erosion was encountered. CONCLUSIONS: Pubovaginal sling operation with a allograft cadaveric fascia lata is an effective treatment for stress urinary incontinence with high cure rate and minimal complication.

Comparison between Anterior Vaginal Wall Sling and Pubovaginal Sling Using Cadaveric Fascia Lata for the Treatment of Female Sphincteric Incontinence / 대한비뇨기과학회지

PURPOSE: Sling procedure has been performed mainly in stress urinary incontinence (SUI) patients with intrinsic sphincteric deficiency (ISD). The purpose of this study was to compare the safety and efficacy of anterior vaginal wall sling with pubovaginal sling using cadaveric fascia lata in the treatment of women with ISD. MATERIALS AND METHODS: Among 43 patients with ISD who had received sling procedure, we retrospectively compared 21 women treated with anterior vaginal wall sling (Group A) to 22 women treated with pubovaginal sling using cadaveric fascia lata (Group B). Preoperative evaluations included cystourethrography, urodynamic study and incontinence staging with SEAPI (stress-related leakage, emptying ability, anatomy, protection and inhibition) classification. The operation time, rate of complication, duration of suprapubic catheterization, length of hospital stay, postoperative presence of stress or urge incontinence, and satisfaction scores were checked. RESULTS: In group A, 17 patients (81.0%) were cured and 3 (14.3%) showed improvement within 14.2 months of mean follow-up, whereas in group B, 18 patients (81.8%) were cured and 3 (13.6%) showed improvement within 13.5 months. De novo urgency was presented in 2 patients (9.5%) from group A and 1 (4.5%) from group B. There was no statistically significant difference between the 2 groups in terms of complication rates and postoperative subjective SEAPI scores. CONCLUSIONS: We concluded that anterior vaginal wall sling and pubovaginal sling using cadaveric fascia lata are both effective surgical treatments for SUI with ISD.

The Effects of a Pubovaginal Sling Procedure, with Martius Labial Fat Pad Interposition, after a Female Urethral Diverticulectomy / 대한비뇨기과학회지

PURPOSE: We evaluated the effects of a pubovaginal sling (PVS), with a Martius labial fat pad interposition (MLFI), on patients with a female urethral diverticulum. MATERIALS AND METHODS: 23 consecutive cases with a female urethral diverticulum were retrospectively reviewed. The pre-operative evaluations included the history, physical examination, voiding cystourethrogram, cystoscopy, transperineal ultrasound and urodynamic studies to investigate the urethral function and the concomitant stress urinary incontinence. The treatment consisted of a transvaginal diverticulectomy alone, or with a PVS only, or combined with a MLFI. RESULTS: A transvaginal diverticulectomy only was performed, using a 3-layer closure, in nine patients (39.1%) and a concomitant PVS with a diverticulectomy in eight (34.8%) with stress urinary incontinence. A MLFI, combined with the above procedure, was performed in six patients (26.1%) with large defects of the urethra following the resection of diverticulum. No women having undergone a diverticulectomy with, or without, a PVS and MLFI had an urethrovaginal fistula, recurrent diverticulum or postoperative incontinence. CONCLUSIONS: In complicated cases, a simultaneous transvaginal diverticulectomy, pubovaginal sling and Martius labial fat pad interposition can be performed safely and effectively.

Estudo comparativo entre sling pubovaginal de parede vaginal e sling de fáscia do reto abdominal no tratamento da incontinência urinária de esforço / Comparative study between vaginal wall sling and rectus fascia pubovaginal sling in the treatment of stress urinary incontinence

OBJETIVO: A cirurgia de sling pubovaginal é utilizada no tratamento da incontinência urinária de esforço (IUE) do tipo III e como resgate na falha de procedimentos anteriores. Tem índice de sucesso variando de 73 a 89 por cento. Podem ser utilizados diversos materiais autólogos e sintéticos com semelhantes resultados. Nosso objetivo foi comparar o sling de parede vaginal com o de fáscia do reto abdominal quanto à eficácia e às complicações. MÉTODO: Foram estudadas 27 pacientes no período de 04/98 a 09/00, divididas em dois grupos: grupo I com nove pacientes submetidas a sling de parede vaginal; grupo II com 18 pacientes submetidas a sling de fáscia do reto abdominal. Todas foram submetidas a um estudo urodinâmico completo, classificadas quanto ao tipo de IUE, e seguidas no ambulatório de urologia. RESULTADOS: grupo I com média de idade de 51,4 anos, tempo de seguimento médio de 14,3 meses. Pressão de Perda aos Esforços (PPE) variando de 50 a 100cmH2O com média de 81,1cmH2O. Houve 66 por cento de complicações. Taxa de sucesso de 88,8 por cento e índice de satisfação 85 pontos. Grupo II com média de idade de 54,2 anos, seguimento médio de 19,3 meses. PPE variando de 45 a 92cmH2O, média de 65,5cmH2O. Houve 72 por cento de complicações e sucesso de 88,8 por cento. Índice de satisfação de 74 pontos. CONCLUSÕES: Os dados encontrados estão de acordo com a literatura, sendo os dois grupos comparáveis quanto à eficácia em período curto de seguimento. O grupo II apresentou maior número de complicações, assim como maior tempo de cateter vesical e menor índice de satisfação geral.

BACKGROUND: Pubovaginal sling is being currently used for the treatment of type III Stress Urinary Incontinence (SUI) and for recurrences after previous procedures. Success rates vary from 73 to 89 percent. Many autologous and allogênic materials have being used with a variable rate of complications. Our objective was to compare the vaginal wall sling to the rectus fascia pubovaginal sling concerning effectiveness and complications. METHOD: Twenty seven patients submitted to pubovaginal sling between 04/98 and 09/00 were divided into two groups: Group I includes 9 patients submitted to vaginal wall sling while Group II with 18 patients submitted to rectus fascia pubovaginal sling. All patients underwent a complete urodinâmic study. They were classified according to the type of SUI and followed at the urology clinic where complications and patient satisfaction index were registered. RESULTS: Group I: The mean age was of 51.4 years. The a mean follow-up period was 14,3 months. The Valsalva leak point pressure (VLPP) varied from 50 to 100cmH2O, with a mean pressure of 81.1cmH2O. Six patients (66 percent) presented postoperative complications. Curative rate was 88.8 percent and patient satisfaction index was 85 points. Group II: The mean age was of 54.2 years; the mean follow-up period was 19,3 months. The VLPP varied from 45 to 92cmH2O, with a mean pressure of 65,5cmH2O. Thirteen patients (72 percent) presented postoperative complications. The curative rate was 88.8 percent and the patient of satisfaction index was 74 points. CONCLUSIONS: Both techniques have a comparable effectiveness during a short follow-up period. The use of rectus fascia pubovaginal sling was associated with more postoperative complications, longer urethral catheterization and lawer patient satisfaction index.

Clinical Outcome Between Fixations of the Rectus Fascia to the Cooper's Ligament and Abdominal Wall in Pubovaginal Sling Operation

PURPOSE: Pubovaginal fascial sling for stress urinary incontinence has never achieved widespread application because of a perception that the complication rate (prolonged urinary retention and secondary detrusor instability) is relatively high. We performed modified pubovaginal fascial sling operation and compared the safety and efficacy of the Cooper's ligament fixation with those of abdominal wall fixation of rectus fascia in pubovaginal sling. MATERIALS AND METHODS: We retrospectively compared 30 women treated with pubovaginal fascial sling procedure as Blaivas described in 1995(Group I) with 30 women treated with a modified technique included fixation of sling to the Cooper's ligament(Group II). Patients were evaluated preoperatively with detailed history, physical examination, urodynamic study and incontinence staging. Postoperative outcome measures and complications were checked. RESULTS: Preoperative parameters, such as clinical and urodynamic data were comparable for both groups. With a mean follow-up of 5.4 months(range 1-14) for group I, 27(90%) were cured. In group II, with a mean follow-up of 6.7 months(range 1-11), 28(93%) were cured. Postoperative de novo urge incontinence was present in 6(20%) patients in group I. The hospital stays, periods of residual urine below 50ml and postoperative lower abdominal pain of group II were significantly lower than those of group I. Each group(97%) was either very satisfied or somewhat satisfied with their outcome. CONCLUSION: Modified pubovaginal fascial sling operation including the use of small piece of rectus fascia and fixation of sling to the Cooper's ligament is an effective treatment for stress incontinence with high cure and low complication rate. However, larger followup is needed to confirm our results.

The Pubovaginal Sling with Rectus Facia for Female Stress Urinary Incontinence

No abstract available in English.

Comparison of Anterior Vaginal Wall Sling and Pubovaginal Fascial Sling in the Management of Intrinsic Sphincteric Deficiency / 대한비뇨기과학회지

PURPOSE: Pubovaginal sling using a strip of rectus fascia to compress the urethra has been the best known treatment for the stress urinary incontinence caused by intrinsic sphincteric deficiency. Recently, sling procedure utilizing the anterior vaginal wall have come forth and the procedure appeared to be performed easily more than the pubovaginal sling. The aim of this study was to compare the safety and efficacy of the pubovaginal versus the anterior vaginal wall slings in treating women with intrinsic sphincteric deficiency. MATERIALS AND METHODS: We retrospectively compared 12 women treated with pubovaginal slings(Group I) for intrinsic sphincteric deficiency to 15 women treated with anterior vaginal wall slings(Group II). Parameters of evaluation included the postoperative presence of stress or urge incontinence, operation time, complications, duration of suprapubic catheterization, hospital stay, days lost from work, and satisfaction score. RESULTS: Baseline clinical and urodynamic data were comparable for both groups. With a mean follow-up of 22 months(range 9-30) for group I, 12(100%) were cured. In group II, with a mean follow-up of 18 months(range 15-20), 14(93%) were cured and 1(6.7%) improved. Postoperative de novo urge incontinence was present in 1(6.7%) patient in group II. Group I(100%) and group II(93%) were either very satisfied or somewhat satisfied with their surgical outcome. The operative time and hospital stays of group II were significantly lower than those of group I. There were no statistically significant differences between the 2 groups in catheterization duration and days lost from work. CONCLUSIONS: We concluded that both techniques are equally effective in treating women with stress incontinence caused by intrinsic sphincteric deficiency. However, the use of anterior vaginal wall slings resulted in significantly shorter operative time and hospital stay compared with pubovaginal slings. Therefore, the anterior vaginal wall slings may be the preferable surgical method in treating intrinsic sphincteric deficiency.