ABSTRACT
Oral modified-release multiple-unit dosa ge forms such as coated pellets have always been more effective therapeutic alternative to conventional single-unit dosage forms. Coated pellets ranging in size,typically,between 0.5-1.0 mm,are produced primarily for the purpose of oral controlled-release dosage forms having gastro-resistant or sustained-release properties or the capability of site-specific drug delivery. With regards to the final dosage form,the multi-particulates are usually formulated into single-unit dosage forms such as filling them into hard gelatin capsules or compressing them into tablets. As drug-delivery systems become more sophisticated,the role of pellets in the design and development of dosage forms is increasing. The safety and efficacy of the formulation is higher than that of other dosage forms. This review provides an update on this research area and discusses the phenomena and mechanisms of the multi-particulate system concluding multiple-unit pellet system and pellet-containing tablets.
ABSTRACT
Oral modified-release multiple-unit dosage forms such as coated pellets have always been more effective therapeutic alternative to conventional single-unit dosage forms. Coated pellets ranging in size, typically, between 0.5-1.0 mm, are produced primarily for the purpose of oral controlled-release dosage forms having gastro-resistant or sustained-release properties or the capability of site-specific drug delivery. With regards to the final dosage form, the multi-particulates are usually formulated into single-unit dosage forms such as filling them into hard gelatin capsules or compressing them into tablets. As drug-delivery systems become more sophisticated, the role of pellets in the design and development of dosage forms is increasing. The safety and efficacy of the formulation is higher than that of other dosage forms. This review provides an update on this research area and discusses the phenomena and mechanisms of the multi-particulate system concluding multiple-unit pellet system and pellet-containing tablets.
ABSTRACT
Objective:To prepare EC impermeable capsule bodies for pulsatile drug delivery system and evaluate the effects of different species dichlormethane mixed solvent and concentration of EC(ethyl cellulose) solution on EC capsule bodies. Methods:The EC impermeable capsule body was prepared by filling method with the EC solution composed of different dichlormethane mixed solvent. The influencing factors on the forming of the EC capsule and the inosculation between the EC capsule and corrosion tablet were investigated by dissolution tester,hardness tester,multifunction pachometer and Sliding caliper. Results:The EC capsule body that was prepared by 11.5%(w/v) 45cp EC solution using the mixedsolvent composed of dichlormethane/ethanol absolute/ethyl acetate(4/0.8/0.2) inosculated well with the corrosion tablet and met the requirements of the pulsatile drug delivery system. Conclusions:The solvent and concentration of the EC solution have great impact on the forming and characterisitcs of the capsule bodies,by optimazing the preparing methods, requirements of the oral pulsatile drug delivery system can be met.
ABSTRACT
Objective To evaluate the in vivo behaviour of the pulsed tablet in six scintigraphic studies.Methods The lag time and the anatomical position at the time of release were detected by scintigraphic evaluation.Results The different types pulsed release tablets all can achieve the lag time in vivo.Conclusion Scintigraphic study is the first considered method to evaluate the in vivo behaviour of the new formulation.