A Case of Pyostomatitis Vegetans which Comes with Ulcerative Colitis / 대한이비인후과학회지

Pyostomatitis vegetans is a rare oral condition characterized by miliary pustules that primarily affect the labial gingiva as well as the buccal and labial mucosa. It is consistently associated with inflammatory bowel disease (IBD) and is a highly specific marker for IBD. Authors are reporting a 45 year-old female patient who developed pyostomatitis vegetans after she was diagnosed as having ulcerative colitis. Our experience indicates that there is an intimate relationship between pyostomatitis vegetans and inflammatory bowel disease (IBD). In a pyostomatitis vegetans patient whose IBD is in dormant state, the diagnosis of IBD can be missed. It is imperative, therefore, to suspect IBD in a patient with pyostomatitis vegetans who has no gastrointestinal symptoms and recommend thorough investigational study of the gatrointestinal system.

A Case of Annular Pustular Psoriasis / 대한피부과학회지

Pustular psoriasis refers to a group of disorder characterized by recalcitrant, sterile pustular eruption. It classified into four clinical patterns: Zumbusch, annular, exanthematous, and localized. Annular pustular psoriasis consists of gyrate, annular lesions with an erythematous, scaly, pustular margin. In contrast to the Zumbusch variety, the annular type is benign and less severe. We herein report a case of annular pustular psoriasis of a 9-year-old girl with review of the literature.

p53 Protein and Proliferating Cell Nuclear Antigen Expression in Epidermal Keratinocytic Neoplasms / 대한피부과학회지

BACKGROUND: Although actinic keratosis and Bowens disease ar considered as carcinoma in situ, most of them are biologically benign and dont progress to invasive squamous cell carcinoma. It is little known why they take the benign courses and which factors are involved in the tumorigenesis. Keratoacanthoma, self-regresi;ing benign tumor, may be sometimes or fused morphologically with well-differentiated squamous cell carcinoma. So it is necessary to find a useful marker to help us distinguish them. OBJECTIVES: We performed this study to gain a better understani ling of biologic behaviour and tumerigenesis of epidermal keiatinocytic neoplasms. METHODS: We investigated the expression of p53 protein and priliferating cell nuclear antigen (PCNA) by an immunohistochemical method on the formalin-fixed, araffinembedded tissue specimens of epidermal keratinocytic neoplasms. RESULTS: Fourteen out of 20 cases of squamous cell carcinoma(70.0%), 14 out of 22 cases of actinic keratosis(63.6%), and 13 out of 20 cases of Bowens disease(65.0%) showed p53 protein expression, but keratoacanthoma was negative. All the tumors studied sho ved significantly increased numbers of PCNA-positive eells when compared with normal epidermis and characteristic distribution pattern. of PCNA-positive cells. Most cases of actinic keratosis exhibited the basal dysplastic pattern, but Bo wenoid variants showed diffuse dysplastic pattern. Karatoacanthoma revealed the marginal pattern and Bowens disease showed the diffuse dysplastic pattern. Well-differentiated squamous cell carcinoria showed the basal dysplastic pattern, while poorly differentiated squamous cell carcinoma revealed d ffuse dysplastic pattern. CONCLUSION: Our results suggest that p53 mutation is a common and early genetic change in the epidermal tumorigenesis and may be used as a good marker for malignan transformation, but it does not seem to correlate with the biollagic behavior or prognosis of epidermal neoplasms. PCNA, which is considered as a proliferation-relaited marker, was expressed with chavaceristic distribution patterns according to the type of tumors, but the frequency of PCNA expression is unlikely to reflct the malignant potential of epidermal neoplasms.

p53 Protein and Proliferating Cell Nuclear Antigen Expression in Epidermal Keratinocytic Neoplasms / 대한피부과학회지

BACKGROUND: Although actinic keratosis and Bowens disease ar considered as carcinoma in situ, most of them are biologically benign and dont progress to invasive squamous cell carcinoma. It is little known why they take the benign courses and which factors are involved in the tumorigenesis. Keratoacanthoma, self-regresi;ing benign tumor, may be sometimes or fused morphologically with well-differentiated squamous cell carcinoma. So it is necessary to find a useful marker to help us distinguish them. OBJECTIVES: We performed this study to gain a better understani ling of biologic behaviour and tumerigenesis of epidermal keiatinocytic neoplasms. METHODS: We investigated the expression of p53 protein and priliferating cell nuclear antigen (PCNA) by an immunohistochemical method on the formalin-fixed, araffinembedded tissue specimens of epidermal keratinocytic neoplasms. RESULTS: Fourteen out of 20 cases of squamous cell carcinoma(70.0%), 14 out of 22 cases of actinic keratosis(63.6%), and 13 out of 20 cases of Bowens disease(65.0%) showed p53 protein expression, but keratoacanthoma was negative. All the tumors studied sho ved significantly increased numbers of PCNA-positive eells when compared with normal epidermis and characteristic distribution pattern. of PCNA-positive cells. Most cases of actinic keratosis exhibited the basal dysplastic pattern, but Bo wenoid variants showed diffuse dysplastic pattern. Karatoacanthoma revealed the marginal pattern and Bowens disease showed the diffuse dysplastic pattern. Well-differentiated squamous cell carcinoria showed the basal dysplastic pattern, while poorly differentiated squamous cell carcinoma revealed d ffuse dysplastic pattern. CONCLUSION: Our results suggest that p53 mutation is a common and early genetic change in the epidermal tumorigenesis and may be used as a good marker for malignan transformation, but it does not seem to correlate with the biollagic behavior or prognosis of epidermal neoplasms. PCNA, which is considered as a proliferation-relaited marker, was expressed with chavaceristic distribution patterns according to the type of tumors, but the frequency of PCNA expression is unlikely to reflct the malignant potential of epidermal neoplasms.

Brain Abscess, Associated with Intracerebral Hematoma in a Child: Report of One Case

We report a rare case of brain abscess associated with intracerebral hematoma in a child at the age of 3. A 3 years old female child has been suffered from the cellulites with pustule on her right leg since 3 weeks before, which has aggravated gradually, and developed acute bacterial meningitis for 2 weeks before transfer to Department of Neurosurgery. The acute bacterial meningitis has been treated for 2 weeks in Pediatric Department. The brain CT revealed a small brain abscesses in the occipital region bilaterally. With methicillin, the clinical progress including C.S.F. findings has got improvement, which has been almost complete. We found the staphylococcus from the pustule on her right leg by smear and culture. At that time, 3 weeks since the onset, suddenly vomiting, consciousness change(drowsy to semicomatose), left hemiparesis developed. Immediate brain CT revealed multiple abscess in both occipital poles with bulky intracerrebral hematoma in right perietooccipital region. Immediate craniectomy was performed for removal of intracranial hematoma, which was ca 50cc in amount, at first, and bilateral trephination with aspiration and drainage for the multiple brain abscess at second. The postoperative course was satisfactory with mannitolization and antibiotic treatment. The recovery was dramatic one.