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Objective To observe and assess the effects of full marathon on hemodynamics and cardiac electrophysiology of marathon amateurs without adverse event after the race.Methods Fiftyone subjects were included in the final analysis of the study,blood pressure,heart rate,body surface electrocardiogram (ECG) of all subjects under static status before the race and within (15-30) min after the race were detected,and sufficient amounts of the peripheral blood and the radial arterial blood specimens of all subjects under static status before the race and within (15-30) min after the race were collected instantly.The peripheral blood was used for measuring markers of muscle injury and NT-proBNP,and the radial arterial blood was taken for blood gas analysis.The QTc interval,QRS,PR interval,and QTd interval were recorded from the 12-lead ECG report.Results Compared with those under static status before the race,the systolic blood pressure,diastolic blood pressure,mean arterial blood pressure and heart rate of all the subjects within (15-30) min after the race were significantly higher (P＜0.05).When the markers of striated muscle injury were compared before and after the competition,levels of CK,cTNI,LDH,and myoglobin after the race were significantly increased compared with them under static status before the race (P ＜0.05),and the level of NT-proBNP after the race was also significantly increased compared with it before the race (P＜0.05).When blood gas analysis before the race was compared with that after the race,the PH values after race were significantly lower than it before race (P＜0.05).The level of lactic acid after the race was significantly higher than it before race (P＜0.05).After the race,the levels of PCO2,SBE and HCO3-decreased significantly compared with those before race (P＜0.05),and the QTc and QTd intervals after the race increased significantly compared with those before the race,however,the QTc interval and QTd interval for all subjects before and after the competition were within the normal range.Conclusions Full marathon significantly affect the myocardial electrophysiological markers of healthy amateur athletes without chronic diseases,but those markers fluctuate within the normal range.
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Objective To observe the effect of CO2 pneumoperitoneum combined with position changes on the stability of cardiac electrophysiology in gynecological laparoscopy. Methods The gynecological laparoscopy was performed for 30 patients to undergo elective gynecological laparoscopy under general anesthesia ,with the pneumoperitoneum pressure of 12 mmHg and the Trendelenburg positionat 15° . The observations and analyses were done over the basic monitoring index and the QT interval (QT),T peak tend interval (Tp-e),heart rate corrected QT interval(QTc),QT dispersion(QTd),Tp-e/QT before anesthesia(T0),after anesthesia(T1),1 min after pneumoperitoneum (T2),30 min after pneumoperitoneum and head-down tilt (T3),30 min after deflation and supine position(T4). Results Compared with the time point of T0,QTd increased significantly at T1(P<0.05) and so it was with QT,QTc,QTd,Tp-e,Tp-e/QT at T2,T3,and T4(P<0.05). Compared with the time point of T2,QTc,QTd,Tp-e,Tp-e/QT significantly increased at T3(P < 0.05). Conclusions CO2 pneumoperitoneum combined with Trendelenburg position can prolong ventricular repolarization duration and destroy the stability of cardiac electrophysiology so it may increase the incidence of cardiovascular events.
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OBJETIVOS E JUSTIFICATIVA: Nosso estudo teve como objetivo investigar o efeito de bupivacaína e levobupivacaína na duração das dispersões do QT, QT corrigido (QTc) e da onda P durante raquianestesia em cesariana. MÉTODOS: Sessenta parturientes programadas para cesariana eletiva ASA I-II foram incluídas no estudo. Exames eletrocardiográficos (ECG) foram feitos após a entrada das pacientes na sala de operação. Frequência cardíaca (FC), pressão arterial não invasiva (PANI), saturação periférica de oxigênio (SpO2) e frequência respiratória (RR) foram registradas. Para o acesso venoso, uma cânula de calibre 18G foi usada. A pré-carga de líquidos foi feita com solução de Ringer com lactato (10 mL.kg-1). Após a pré-carga de líquidos, um segundo exame eletrocardiográfico foi feito e as pacientes foram designadas aleatoriamente para dois grupos. O Grupo B (n = 30) recebeu 10 mg de bupivacaína e o Grupo L (n = 30) recebeu 10 mg de levobupivacaína para raquianestesia. Exames ECG foram repetidos nos minutos um, cinco e 10 após a anestesia. FC, PANI, SpO2, FR e os níveis de bloqueio sensorial também foram registrados nos mesmos intervalos de tempo. Em intervalos de tempo pré-determinados de raquianestesia, as durações da dispersão da onda P (OPd), QT (QTd) e QTc (QTcd) foram medidas a partir dos registros do ECG. As durações de QT e QTc foram calculadas com a fórmula de Bazzett. RESULTADOS: Não houve diferença entre os dois grupos quanto aos níveis de bloqueio, parâmetros hemodinâmicos, OPd, QTd, QTc e QTcd. CONCLUSÃO: Levobupivacaína e bupivacaína podem ser os anestésicos de escolha para raquianestesia em grávidas com dispersões prolongadas da OPd e QTcd no período pré-operatório.
BACKGROUND AND OBJECTIVES: In our study we aimed to investigate the effect of bupivacaine and levobupivacaine on QT, corrected QT (QTc), and P wave dispersion durations during spinal anesthesia in cesarean section. METHODS: Sixty parturients scheduled for elective cesarean section in ASA I-II risk groups were included in the study. Baseline electrocardiographic (ECG) records of the patients were obtained in the operation room. Heart rate (HR), non-invasive blood pressure (NIBP), peripheral oxygen saturation (SpO2) and respiration rates (RR) were recorded. Venous cannulation was performed with 18G cannula and fluid preload made with 10 mL.kg-1. Lactated Ringer solution. After fluid preload, second ECG recordings were taken and the patients were randomly separated into two groups. Group B (n = 30) received 10 mg of bupivacaine and Group L (n = 30) received 10 mg of levobupivacaine for spinal anesthesia. ECG recordings were repeated at 1, 5 and 10 minutes after spinal block. HR, NIBP, SpO2 , RR and sensory block levels were also recorded at the same time intervals. At predetermined time intervals of spinal anesthesia, P wave dispersion (Pwd), QT dispersion (QTd), and QTc dispersion (QTcd) durations were measured from ECG records. QT and QTc durations are calculated with Bazzett formula. RESULTS: There was no difference between two groups according to block levels, hemodynamic parameters, Pwd, QTd, QTc and QTcd durations. CONCLUSION: Bupivacaine and levobupivacaine may be preferred in spinal anesthesia in pregnant patients who have extended Pwd and QTcd preoperatively.
OBJETIVOS Y JUSTIFICATIVA: Nuestro estudio tuvo como objetivo investigar el efecto de la bupivacaína y la levobupivacaína en la duración de las dispersiones del QT, QT corregido (QTc) y de la onda P durante la raquianestesia en cesárea. MÉTODOS: Sesenta parturientes programadas para cesárea electiva en grupos de riesgo ASA I-II fueron incluidas en el estudio. Los exámenes electrocardiográficos (ECG) se hicieron después de la entrada de las pacientes al quirófano. Se registraron la frecuencia cardíaca (FC), presión arterial no invasiva (PANI), saturación periférica de oxígeno (SpO2) y frecuencia respiratoria (RR). Para el acceso venoso, se usó una cánula de calibre 18. La precarga de líquidos fue hecha con una solución de Ringer con lactato (10 mL.kg-1). Después de la precarga de líquidos, un segundo examen electrocardiográfico se hizo y las pacientes fueron designadas aleatoriamente para dos grupos. El Grupo B (n = 30) recibió 10 mg de bupivacaína y el Grupo L (n = 30) recibió 10 mg de levobupivacaína para la raquianestesia. Los exámenes ECG se repitieron en los minutos 1, 5 y 10 después de la anestesia. FC, PANI, SpO2, FR y los niveles de bloqueo sensorial también fueron registrados en los mismos intervalos de tiempo. En intervalos de tiempo predeterminados de raquianestesia, las duraciones de la dispersión de la onda P (OPd), QT (QTd) y QTc (QTcd) fueron medidas a partir de los registros del ECG. Las duraciones de QT y QTc fueron calculadas con la fórmula de Bazzett. RESULTADOS: No hubo diferencia entre los dos grupos en cuanto a los niveles de bloqueo, parámetros hemodinámicos, OPd, QTd, QTc y QTcd. CONCLUSIONES: La levobupivacaína y la bupivacaína pueden ser los anestésicos de elección para la raquianestesia en las embarazadas con dispersiones prolongadas de la OPd y QTcd en el período preoperatorio.
Subject(s)
Adult , Female , Humans , Pregnancy , Anesthesia, Obstetrical , Anesthesia, Spinal , Anesthetics, Local/pharmacology , Bupivacaine/pharmacology , Cesarean Section , Electrocardiography/drug effects , Bupivacaine/analogs & derivatives , Double-Blind Method , Prospective StudiesABSTRACT
Objective Attempting to create a chemical diversity" combinatorial library consisting of active components of Chinese materia medica compounds. Methods This paper was based on the theory of "thinking and method of 'combinatorial screening' of Chinese material medica compound", using the Qingluo Tongbi Decoction (QTD) which has exact effect against rheumatoid arthritis as system. Re-combination group of the formulation was used and various industrial separation techniques, such as resin and membrane, were used to replace the diversity of combinatorial chemistry synthetic route. Different products were used to establish combinatorial library using "Building Block". Results Different contents of active components in each "Building Block" were found during the establishment of combinatorial libraries. AB-8 resin had good adsorption and desorption functions on sinomenine, and good refined effects on saponin as well. The contents of kirenol were different in each "Building Block" of different combinations. Each "Building Block" had a relative high content of total flavonoids. Conclusion Different combinations and separation techniques lead the differences in types and contents of chemical constituents. So certain pharmacodynamic experiments are needed to evaluate the preparation and to filter out the relevant active "Building Blocks".
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Objective To investigate the effect of acute intervention therapy on the QT dispersions(QTd)and correction QTd(QTcd)in patients with myocardial infarction. Methods112 patients with myocardial infarction who had received acute percutaneous coronary intervention(PCI)as study group,and divided it into three sub-group as Left anterior descending group,Left circumflex group and Right coronary group.70 infarction patients without acute intervention therapy as control group.And 12 lead standard surfaces ECG were recorded at beginning and 24h and 48h.respectively. ResultsAfter the PCI therapy,QTd and QTcd in study group improved significantly.However,QTd and QTcd had no difference among three sub-group. ConclusionThe acute intervention therapy could improve QTd and QTcd in patients with myocardial infarction.The vascular location had no difference in myocardial repolarization.
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0 05) for inducible VT; Utility of QTD≥70ms combined with positive VLP had a more satisfied outcome than using either of these abnormalities in predicting inducible VT. Conclusion QTD is an easily measurable electrocardiographic index for predicting coronary heart disease.