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Objective::To evaluate theclinical efficacy of Zhiwei pills combined with Hperadication programme for gastritis with liver and stomach Qi stagnation syndrome caused by helicobacter pylori (Hp) and to investigate its effect on antioxidant stress. Method::One hundred and sixty patients were randomly divided into control group (80 cases) and observation group (80 cases) by random number table. Patients in control group gotHperadication programme, and esomeprazole magnesium enteric-coated tablets, 20 mg/time, 1 time/day. Bismuth potassium citrate tablets, 0.3 g/time, 2 times/days. Amoxicillin capsules, 1.0 g/time, 2 times/days. Furazolidone tablets, 0.1 g/time, 2 times/days, all for 14 days. Based on the treatment in control group, the patients in observation group additionally got Zhiwei pills, 6 g/time, 3 times/day. The course of treatment was 8 weeks in both groups. After treatment, eradication of Hp was detected. Before and after treatment, scores of liver and stomach Qi stagnation syndrome were graded. After treatment, patients received gastroscopy and pathological review, and patient report outcome indicators (PRO) both before and after treatment were discussed. The levels of tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), IL-8, oxidative dismutase (SOD), glutathione peroxidase (GSH-Px) and malondialdehyde (MDA) were detected both before and after treatment. Result::Negative conversion rate of Hp was(70/75) 93.33% in observation group, higher than(58/71) 81.69% in control group (P<0.05). In the analysis of rank sum test, effect of traditional Chinese medical(TCM) syndrome in observation group was better than that in control group (Z=2.183, P<0.05), and clinical efficacy was also better than that in control group (Z=2.175, P<0.05). Scores of liver and stomach Qi stagnation syndrome and total PRO score in observation group were all lower than those in control group (P<0.01). Levels of TNF-α, IL-1β, IL-8 and MDA were lower than those in control group (P<0.01), while levels of SOD and GSH-Px were higher than those in control group (P<0.01). Conclusion::Zhiwei pills combined with Hperadication programme can improve the eradication rate of Hp, alleviate clinical symptoms, improve the quality of life of patients, inhibit inflammatory reaction and anti-oxidative stress, and improve the curative effect and clinical efficacy of TCM syndromes in the treatment of gastritis with liver and stomach Qi stagnation syndrome, so it is worth for further study and use.
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Objective To evaluate the efficacy of modified Liumo decoction combined with polyethylene glycol 4000 powder in the treatment of functional constipation (FC) with Qi stagnation type.Methods A total of 92 FC patients who met the inclusion criteria were divided into two groups by random number table method,46 in each group.The control group was treated with polyethylene glycol 4000 powder orally on the basis of routine treatment.The treatment group was treated with modified Liumo decoction on the basis of the control group.Both groups were treated for 4 weeks and followed up for 6 months.TCM syndrome was scored before and after treatment.The Serum levels of NOS,NO,SOD,MDA and glutathione (GSH) were detected by ELISA.The adverse reaction during treatment was observed and the recurrence rate was calculated.Results After treatment,the score of defecation discomfort,abdominal distention,bowel ringing,sagittal frequency and chest and rib fullness in the treatment group was significantly lower than those in the control group (t=-4.749,-5.140,-5.835,-6.883,-6.919,all Ps＜0.01).The level of serum NOS (26.95 ± 5.11 U/ml vs.31.36± 7.61 U/ml,t=-3.263),NO (61.91 ± 12.62 U/ml vs.72.35 ± 12.03 U/ml,t=-4.061) in the treatment group was significantly lower than those in the control group (P＜0.01),the level of serum SOD (24.66 ± 3.82 U/ml vs.21.39 ± 3.41 U/ml,t=4.331),GSH (12.15 ± 1.52 U/ml vs.8.13 ± 1.42 U/ml,t=-1 3.278) in the treatment group was significantly higher than those of the control group (P＜0.01),while the MAD level (2.73 ± 0.83 U/ml vs.4.92 ± 0.75 U/ml,t=13.108) in the treatment group was significantly lower than that in the control group (P＜0.01).After 6 months of follow-up,the recurrence rate of the control group was 27.3％ (9/33),which was significantly higher than 4.8％ (2/42) of the treatment group,and the difference was statistically significant (x2=7.482,P=0.006).Conclusions The modified Liumo decoction combined with polyethylene glycol 4000 powder can improve the levels of intestinal neurotransmitters,SOD,MDA and GSH in patients with FC,alleviate the symptoms of traditional Chinese medicine and reduce the recurrence rate.
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Objective:To investigate the association between polymorphisms of estrogen receptor ? (ER?) gene (rs3020444) and perimenopausal syndrome (PS) in patients with liver qi stagnation syndrome (LQSS). Metheds:The ER?T/C genotype in 100 patients of PS of LQSS type (PS-LQSS group),86 patients of PS of non-LSDS type (PS-non-LQSS group) and 100 healthy subjects (control) was determined by polymerase chain reaction and restriction fragment length polymorphism (PCR-RFLP) assay. Results:Partitions of ?2 method showed that the higher prevalence of ER?-TT genotypes was noted in PS-LQSS group (?2=8.307,P=0.004),and the higher prevalence of T alleles was noted in PS-LQSS group (?2=7.129,P=0.008). and Multinomial logistic-regression indicated that the odds ratios (OR) of the ER?-TT genotypes vs TC/CC for PS-LQSS was 2.222 (95%CI:1.172-4.744,P=0.015) after adjusting for common miscellaneous factors. Conclusions:It was suggested that ER?-TT genotypes was significantly associated with PS-LQSS,and ESR?-TT may be one of the genes that contribute to PS-LQSS.
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Objective To survey the significance of specific immune response in the relationship between Sagnation the Liver-qi syndrome and the spleen Deficiency syndrome.Methods The rats with the Liver-qi Stagnation syndrome and the Spleen Deficiency syndrome were respectively corresponding and crossely treated with Radix Bupleuric dispersing the stagnated Liver-qi powder Decolion of Four Noble Drugs. Their T, B lymphocyte activity and specific immune response indexes changes (such as IgG, IgM in the serum) were respectively observed by lymphocyte transformation test and immunoturbidimetry. Results There were no notable changes about the IgG level among all kinds of groups. The IgM levels in the Liver-qi Stagnation syndrome and the Spleen Deficiency syndrome decreased, especially in the Liver-qi Stagnation syndrome (P0 05), Decolion of Four Noble Drugs could increase the IgM level of the patients with the Liver-qi Stagnation syndrome and the Spleen Deficiency syndrome (P0 05); The T lymphocyte transformation rate of the Spleen Deficiency syndrome obviously decreased, and Decolion of Four Noble Drugs could recover it to the normal level (P0 05). The rate of B lymphocyte transformation the Liver-qi Stagnation syndrome's also showed the increasing tenderly (P0 05). Conclusions The relationship between the Liver-qi Stagnation syndrome and the Spleen Deficiency syndrome could occur in the phase of antigen presentation, especially in the phase of the T H cell activation stimulated by antigen. Radix Bupleuric dispersing the stagnated Liver-qi powder could enhance T, B lymphocyte activities by reverse the Liver-qi Stagnation syndrome,and Decolion of Four Noble Drugs could enhance T lymphocyte by improving the Spleen Deficiency syndrome.
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Objective To evaluate the effect and safety of Houpo Paiqi Mixture(HPM)in treating early enteroparalysis classified as Qi-stagnation syndrome after abdominal non-gastrointestinal operation.Methods A multi-center,randomized,controlled study was carried out.The treatment group(n = 327)was treated with HPM(50 mL P.O,6 and 10 hours after operation)and the control group(n=108)with cisapride tablets(10 mg P.O,6 and 10 hours after operation).The course of treatment lasted 24 hours.Results A significant difference(P
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Objective To study the mechanism of liver-qi stagnation syndrome of rat models. Methods The binding method was used to make rat models of liver-qi stagnation syndrome and the quantitative changes of hypothalamus norepinephrine (NE), epinephrine (E), dopamine (DA), and 5-hydroxytryptamine (5-HT) before and after modeling were determined with reversed phase ion pair (RP-IP)-HPLC. Results The level of E, DA and 5-HT was remarkably increased (P