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@#AIM: To systematically evaluate the effectiveness and safety of Qiju Dihuang Pill on xerophthalmia. <p>METHODS: PubMed, EMbase, Web of Science. The Cochrane Library, CBM, CNKI, VIP and WanFang Data databases were electronically searched to identify randomized controlled trials(RCTs)of Qiju Dihuang Pill on xerophthalmia from the inception of the databases to June 2019. Two reviewers independently screened literatures, extracted data and assessed risk of bias of the included trials. The Meta-analysis was conducted with RevMan 5.3 and Stata 12.0 software. <p>RESULTS: Totally 17 RCTs with 1 662 patients were included. The results of the Meta-analysis showed that, compared with the control group, the Qiju Dihuang Pill group had statistical difference in BUT(MD=4.32, 95% <i>CI</i> 3.15 to 5.49, <i>P</i><0.00001), SⅠt(SMD =1.07, 95% <i>CI</i> 0.71 to 1.42, <i>P</i><0.00001), FL(MD= -1.01, 95% <i>CI</i> -1.61 to -0.40, <i>P</i>=0.001), efficiency(<i>OR</i>=7.22, 95%<i> CI</i> 4.36 to 11.93, <i>P</i><0.00001). There were no serious adverse reactions in either group. The results of GRADE showed that the level of evidence of BUT, SⅠt, efficiency was low, and the level of evidence of FL was very low.<p>CONCLUSION: The current evidence indicated that Qiju Dihuang Pill had a better therapeutic effect on xerophthalmia than conventional treatment, and no serious adverse reactions were reported in the study. Considering the limitations of the quality and quantity of the included studies,more well-designed randomized controlled trials are required to verify the above conclusions.
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@#AIM: To explore the therapy efficacy of different drugs for dry eyes after cataract surgery.<p>METHODS: Collected from June 2014 to June 2016 in patients with dry eyes in our departments of cataract surgery, a total of 60 cases with 120 eyes, according to the doctor order divided into pure sodium hyaluronate eye drops group 20 cases(40 eyes, sodium hyaluronate eye drops combined pranoprofen eye drops group 20 cases(40 eyes), sodium hyaluronate eye drops combined pranoprofen eye drops and Qiju Dihuang pill group of 20 cases(40 eyes). All patients were treated for 1mo. Observation of break up time(BUT), Shimmer Ⅰ test(SIt)and fluorescein corneal staining(FI)were recorded before the treatment and 1, 2wk, 1, 3mo after treatment. <p>RESULTS: Difference of efficient rates of three groups 1mo after treatment were statistically significant(<i>P</i><0.05). BUT: there was no statistically significant difference among three groups before treatment(<i>P</i>>0.05); at 1, 3mo after treatment compared with before treatment, the differences of the three groups were statistically significant(<i>P</i><0.05); among the three groups 1, 2wk and 1mo after treatment, the differences were statistically significant(<i>P</i><0.05); at 3mo after treatment the difference among the three groups was not statistically significant(<i>P</i>>0.05); but sodium hyaluronate eye drops combined pranoprofen eye drops and Qiju Dihuang pill group(12.14±1.97s)was superior to pure sodium hyaluronate eye drops group(10.54±1.88s)and sodium hyaluronate eye drops combined pranoprofen eye drops group(12.05±1.63s).SIt: there was no statistically significant difference among three groups before treatment(<i>P</i>>0.05); at 1, 3mo after treatment compared with before treatment, the differences of the three groups were statistically significant(<i>P</i><0.05); among the three groups 1, 2wk and 1mo after treatment, the differences were statistically significant(<i>P</i><0.05); but sodium hyaluronate eye drops combined pranoprofen eye drops and Qiju Dihuang pill group(14.24±1.89mm/5min)was superior to pure sodium hyaluronate eye drops group(12.22±2.54mm/5min)and sodium hyaluronate eye drops combined pranoprofen eye drops group(12.27±2.31mm/5 min).FL: there was no statistically significant difference among three groups before treatment(<i>P</i>>0.05); at 1, 3mo after treatment compared with before treatment, the differences of the three groups were statistically significant(<i>P</i><0.05); among the three groups 1, 2wk and 1mo after treatment, the differences were statistically significant(<i>P</i><0.05); at 3mo after treatment the difference among the three groups was not statistically significant(<i>P</i>>0.05).<p>CONCLUSION:Sodium hyaluronate eye drops combined pranoprofen eye drops and Qiju Dihuang pill in the treatment of dry eye after cataract surgery is better than that of sodium hyaluronate eye drops combined pranoprofen eye drops group and simple application of sodium hyaluronate eye drops, which can better improve the visual function, improve tear film stability, get better treatment effect.
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Objective To discusse the fouling mechanism of 0.2 ?m Al_2O_3 ceramic membrane in the microfiltration of Qiju Dihuang Pill aqueous extract. Methods Qiju Dihuang Pill aqueous extract was microfiltered in this experiment. The distributions of filtration resistance were studied according to the Darcy-Poiseuille principle. The substance of deposit on the membrane surface was analysed by Fourior transform infra-red spectrum and particle diameter analysis. The characteristic of the surface and cross section of the polluted membrane was observed by SEM. Results The filtration resistance was mainly concentrated on the surface of deposit resistance, the membrane itself and the concentration polarization resistance were less important, and the pore blocking resistance was the least important. Moreover, this result was proved by SEM analysis. The molecule of the fouling substance mainly contained peptid, carbonyl, and hydroxy bonds by IR. The particle size distribution of the deposit substance on the polluted membrane surface: The particle radius taking a larger percentage in volume concentrated in 18.267 ?m around, while the particle radius taking a larger percentage in quantity concentrated in 0.424 ?m around. Conclusion Study on the fouling mechanism of the membrane in the microfiltration provides a great significant guidance for exploring the effective measure of relieving the reduced membrane flux and the appropriate cleaning procotrol.