ABSTRACT
Objective: To reevaluate the purification process of Qingnao Fushen Oral Liquid (QFOL). Methods: The orthogonal experiment of adsorption process of the activated carbon was optimized with the diversion rates of berberine and total flavonoids and the reduction of solid content as indexes. The aperture, pressure, temperature, and collection were optimized with the diversion rates of berberine and total flavonoids and the reduction of solid content as indexes. At the same time, the method of membrane cleaning was screened through the combination of different cleaners. Results: The adsorption process of activated carbon was as following: the usage of activated carbon was 0.1%, at normal atmospheric temperature, and the adsorption time was 20 min. The optimal process was aperture 200 nm, pressure 0.10 MPa, temperature 40℃, and collection 1.25 times of the original volume. The cleaning method of membrane is to use NaOH to clean for 30 min and HNO3 to clean for 30 min. Conclusion: The purified QFOL can be obtained by this technique, which is helpful for industrialization.