Association of MTR and MTRR genes and oral health-related quality of life in children with dental caries

Abstract This study aimed to assess whether genetic polymorphisms in MTR and MTRR are potential biomarkers of oral health-related quality of life (OHRQoL) in children with caries. A cross-sectional study was designed wherein pairs of parents/caregivers and children (aged two-five years) were selected. Clinical examination was used to detect dental caries, which were classified as low-severity and high-severity caries. The Early Childhood Oral Health Impact Scale (ECOHIS) questionnaire was used to assess OHRQoL. Genomic DNA extracted from the saliva was used to analyze two missense genetic polymorphisms: MTR (rs1805087) and MTRR (rs1801394). Mann-Whitney non-parametric test was used to analyze candidate genes with OHRQoL scale and domain, with a significance level of p≤0.05. MTR (rs1805087) was found associated (p = 0.05) with children's OHRQoL subscale scores in the dominant model (GG + AG). Genetic polymorphisms in MTR may increase the risk of poor OHRQoL in children with caries. Further studies are needed to investigate genetics, molecular factors, and OHRQoL.

Comparação da qualidade de vida entre pacientes pediátricos com dermatite atópica e com outras dermatoses no sul do Brasil / Comparison of the quality of life between pediatric patients with atopic dermatitis and other dermatoses in southern Brazil

Introdução: Doenças dermatológicas podem influenciar o estado psicológico, as relações pessoais e as atividades diárias dos pacientes pediátricos (1,2). Uma avaliação cuidadosa desses pacientes é fundamental para investigar os impactos das dermatoses em suas vidas. O objetivo do estudo é comparar a qualidade de vida de pacientes pediátricos com dermatite atópica (DA) em relação aos pacientes com outras dermatoses em um centro de referência em dermatologia no sul do Brasil. Métodos: Estudo transversal, com amostra por conveniência entre pacientes de 4 a 16 anos, atendidos durante o período de 2018 a 2019 em um ambulatório de dermatologia. Aplicou-se questionário com variáveis sociodemográficas e o Escore de qualidade de vida em Dermatologia Infantil (CDLQI). Resultados: A amostra foi composta por 70 pacientes com média de idade de 9,36 anos. As principais dermatoses que compuseram o grupo de pacientes com outras dermatoses (41,4%) foram molusco contagioso, vitiligo e acne. Pacientes com DA apresentaram uma pior qualidade de vida (média CDLQI 7,41) comparados com os pacientes que apresentavam outras dermatoses (média CDLQI 4,41), sendo os domínios sono e tratamento responsáveis por essa diferença, apresentando valor médio do CDLQI de 1,12 e 0,76 respectivamente na DA, e 0,34 e 0,31 nas outras dermatoses. Conclusão: Crianças com DA apresentam pior qualidade de vida, particularmente em relação ao sono e a realização do seu tratamento, quando comparadas às crianças com outras dermatoses. É necessária uma abordagem multidisciplinar com suporte psicológico para garantir um adequado manejo e reduzir os prejuízos na qualidade de vida desses pacientes.

Introduction: Skin diseases can influence the psychological state, personal relationships and daily activities of pediatric patients (1,2). A careful assessment of these patients is essential to investigate the impacts of dermatoses on their lives. The study was designed to compare the quality of life of pediatric patients with atopic dermatitis (AD) in relation to patients with other dermatoses at a dermatology referral center in southern Brazil. Methods: A cross-sectional study, with a convenience sample among patients aged 4 to 16 years, treated during the period from 2018 to 2019 in a dermatology outpatient clinic. A questionnaire with sociodemographic variables and the Child Dermatology Quality of Life Index (CDLQI) were used. Results: The sample consisted of 70 patients with a mean age of 9.36 years. The main dermatoses that made up the group of patients with other dermatoses (41.4%) were molluscum contagiosum, vitiligo and acne. Patients with AD had a worse quality of life (mean CDLQI 7.41) compared to patients with other dermatoses (mean CDLQI 4.41), with sleep and treatment domains responsible for this difference, with mean CDLQI values of 1.12 and 0.76, respectively, in AD, and 0.34 and 0.31 in the other dermatoses. Conclusion: Children with AD have a worse quality of life, particularly in terms of sleep and treatment, as compared to children with other dermatoses. A multidisciplinary approach with psychological support is necessary to ensure adequate management and reduce the losses in these patients' quality of life.

Impacto del cáncer en la condición física y calidad de vida en niños, niñas y adolescentes

Resumen El cáncer infantil comprende diferentes y numerosos tipos de tumores que se desarrollan en niños y adolescentes de 0 a 19 años, cuyos efectos secundarios en su mayoría, derivan de los tratamientos recibidos y pueden persistir durante el tiempo. Objetivo. Determinar el impacto del cáncer en la condición física y calidad de vida en niños, niñas y adolescentes. Materiales y métodos. De enfoque cuali-cuantitativo, con alcance descriptivo y relacional, posee un diseño no experimental de corte transversal, una muestra poblacional de 104 pacientes de ambos sexos y en edades de 5 a 18 años. Resultados. Predomina el sexo masculino y la edad promedio del grupo está entre los 9 y 12 años, siendo la Leucemia linfoblástica aguda la de mayor incidencia; se muestra déficit en la fuerza muscular, flexibilidad, predominio de fatiga y escasa o nula actividad física. Conclusión. El análisis de este estudio y sus conclusiones, se puede evidenciar que existen diferentes estados de bienestar y que su condición física se puede ver influenciada por el tipo cáncer, duración y tratamiento recibido, lo cual trae como consecuencia en ellos, una marcada baja en su funcionabilidad y por ende impacto en la ejecución e integración de sus actividades de la vida diaria y calidad de vida.

Abstract Childhood cancer comprises different and numerous types of tumors that develop in children and adolescents from 0 to 19 years of age, the majority of which side effects derive from the treatments received and can persist over time. Objective: To determine the impact of cancer on the physical condition and quality of life in children and adolescents. Materials and methods: With a qualitative-quantitative approach, with a descriptive and relational scope, it has a non-experimental cross-sectional design, a population sample of 104 patients of both sexes and ages 5 to 18 years. Results: males predominate and the average age of the group is between 9 and 12 years old, with acute lymphoblastic leukemia the one with the highest incidence; It shows a deficit in muscular strength, flexibility, a predominance of fatigue and little or no physical activity. Conclusion: The analysis of this study and its conclusions, it can be evidenced that there are different states of well-being and that their physical condition can be influenced by the type of cancer, duration and treatment received, which results in a marked decrease in its functionality and therefore impact on the execution and integration of its activities of daily life and quality of life.

Resumo O câncer infantil compreende diferentes e numerosos tipos de tumores que se desenvolvem em crianças e adolescentes de 0 a 19 anos, a maioria dos quais efeitos colaterais são decorrentes dos tratamentos recebidos e podem persistir ao longo do tempo. Objetivo. Determinar o impacto do câncer na condição física e na qualidade de vida de crianças e adolescentes. Materiais e métodos. Com abordagem qualitativo-quantitativa, com abrangência descritiva e relacional, tem desenho transversal não experimental, amostra populacional de 104 pacientes de ambos os sexos e idades de 5 a 18 anos. Resultados. o sexo masculino predomina e a idade média do grupo está entre 9 e 12 anos, sendo a leucemia linfoblástica aguda a de maior incidência; Apresenta déficit de força muscular, flexibilidade, predomínio de fadiga e pouca ou nenhuma atividade física. Conclusão. A análise deste estudo e suas conclusões, pode ser evidenciado que existem diferentes estados de bem-estar e que sua condição física pode ser influenciada pelo tipo de câncer, duração e tratamento recebido, o que resulta em uma diminuição acentuada do sua funcionalidade e, portanto, impactam na execução e integração de suas atividades de vida diária e na qualidade de vida.

Oral Health-related Quality of Life Impact in Children and Children With Special Needs Undergoing Dental Treatment Under General Anaesthesia – An Institutional Study

@#Introduction: Numerous studies have examined both the effect of caries and dental care under general anaesthesia affecting children and children with special needs, but there is still scant information on the relationship between both classes. Thus this project is aimed i) to compare oral health-related quality of life in children and children with special needs undergoing dental care under general anaesthesia (GA) and ii) To compare the impact on oral health-related quality of life in children and children with special needs. Methods: Forty-six children (25 normal children, 21 children with special needs) are recruited. Participating parents completed a brief version of the Perceptions Questionnaire (P-CPQ) and Family Impact Scale (FIS) before the treatment and subsequent follow-up appointments (4 weeks to 8 weeks). Oral symptoms, social health, psychology, functional limitation, and family effect ratings, the mean, standard deviations, and statistical differences between groups were analysed. Results: 52.2% of both parent groups rated the oral health status of their children as low before GA, and it improved considerably, with 69.6% of parents rating post-operatively as healthy. The most recorded impacts at baseline were pain, discomfort, often annoyed and angry among children and parents feeling guilty and upset due to the condition of the child. Conclusion: Oral rehabilitation under GA leads to the immediate improvement of oral health, mental, and social quality among the children in both groups. However, for parents of children with special needs, despite the effort to eradicate dental-related issues, the overall quality of life shows no significant improvements.