ABSTRACT
Background: Diabetes has a negative impact on patient’s quality of life (QoL). Comorbidities and polypharmacy further worsen their QoL. Thus, in addition to glycemic control, assessment of QoL is also gaining importance. Objective: The objective of this study was to evaluate QoL in patients of type 2 diabetes mellitus (T2DM) with hypertension after add?on empagliflozin to triple drug therapy (metformin, teneligliptin, and glimepiride). Materials and Methods: A prospective research was done on T2DM patients with hypertension, who visited a tertiary care referral institute’s endocrine outpatient clinic. For 3 months, empagliflozin, 25 mg once daily, was administered as an add?on treatment with metformin, teneligliptin, and glimepiride. In addition to clinical assessment, an Urdu-translated QoL instrument for Indian diabetes patients was used to conduct QoL study. The QoL outcomes prior to empagliflozin add?on were compared with those obtained at the conclusion of the 3 months of treatment. Results: Empagliflozin as an add?on therapy significantly improved various aspects of QoL like role limitation due to physical health, physical endurance, general health, symptom botherness, financial worries, emotional/mental health, and diet satisfaction (P < 0.001). It also improved glycemic and blood pressure parameters significantly. Conclusion: QoL is an essential measure with respect to patient?centered treatment approach. Empagliflozin, as an add?on medication, improved QoL, glycemic parameters and blood pressure in T2DM patients with hypertension. It can be recommended as an add?on, but more research with a larger sample size is required.
ABSTRACT
India has the large number of diabetic patients, and the number is expected to raise to 69.9 million by 2025. “Quality of life (QOL)” evaluation has emerged as an important outcome measure for chronic disease management. In diabetes, psychosocial factors have an important impact on self-care, acceptance of therapeutic regimens, treatment success, and QOL. Aims and Objectives: The aim of the study was to find out the QOL among the diabetic patients attending the outpatient department of tertiary care hospital in Bagalkot city. Methodology: It is a cross-sectional descriptive study, which was undertaken at a tertiary care hospital in Bagalkot city. The duration of the study was from August 10, 2016 to October 25, 2016. A sample size of 180 was obtained after considering the prevalence of diabetes in Karnataka as 10.22%. Patients attending the hospital for outpatient services were interviewed in their own language after obtaining the consent. QOL instrument for Indian Diabetes Patients questionnaire was used it is a reliable, valid, and sensitive tool for the assessment of diabetes-specific QOL in Indian subjects. Statistical analysis was done using Microsoft Excel 2010 and SPSS 20.1 trial version. Chi-square and Fisher’s exact test was used. Results: The mean age of study participants was 58.14 ± 13.46 years. 31.8% of the study participants were on insulin therapy. 52.3% of the males in the study had good QOL. The patients who were obese had poorer QOL than the patients with overweight and normal body mass index; this was statistically significant. Married participants had better QOL. In participants with comorbidities, QOL was poorer when compared to those without comorbidities; this difference was statistically significant.
ABSTRACT
El objetivo del presente trabajo consiste en revisar el concepto de calidad de vida en la infancia, así como los criterios básicos que se requieren para la adaptación, construcción y aplicación de instrumentos, para su evaluación y medición. Para ello se recopiló información reportada en diferentes bases de datos y posteriormente se examinó por medio de la elaboración de resúmenes analíticos especializados (RAES) y tablas de análisis. Los resultados y análisis de documentos muestran que, aunque diversos autores exponen que no existe un consenso en la definición de la calidad de vida para la infancia y que no es posible diferenciar entre ésta y la calidad de vida relacionada con la salud, pueden identificarse elementos que posibilitan la conceptualización y la distinción entre estos términos.
The purpose of this study consists in revising the concept of quality of life and the basic criteria that are required for adaptation, construction and implementation of instruments in childhood. This collected information from different databases, which was later analyzed by specialized analitical abstracts and tables of analysis. The results show that although different authors argue that there is no consensus on the definition of quality of life for children and that it is not possible to differentiate between thisand the quality of life related to health, the analysis conducted over labor showed that one there is a distinction between these terms.
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BACKGROUND: The measurement of quality of life (QOL) is increasingly important in patients with skin diseases. However, no study has objectively analyzed these trends in the Korean literature. OBJECTIVE: The aim of this study was to analyze original articles that measure QOL in the Korean Journal of Dermatology and to evaluate the use of QOL instruments. METHODS: We collected 14 original articles that measure QOL from the Korean Journal of Dermatology (1960 to 2008) and analyzed these articles for annual changes of the number of articles, the kind and frequency of QOL instrument, and the kind of skin disease in the articles. We also analyzed 66 original articles from the Journal of the American Academy of Dermatology (JAAD) (1979 to 2008) in the same way. RESULTS: In general, the number of articles that measure QOL in the Korean Journal of Dermatology increased. The articles for psoriasis and acne vulgaris accounted for 21.4% of the articles each. Dermatology-specific instruments were the most common QOL instruments used. These results were similar for the JAAD. Of the dermatology-specific instruments, the skindex-29 was used most frequently in the Korean Journal of Dermatology, and the Dermatology Life Quality Index in the JAAD. CONCLUSION: Measuring the impact of skin disease on QOL is increasingly important. Domestic assessment of QOL in skin disease using novel QOL instruments should increase to conform to international standards to allow Korean dermatologists to provide better care to their patients.
Subject(s)
Humans , Acne Vulgaris , Dermatology , Psoriasis , Quality of Life , Skin DiseasesABSTRACT
BACKGROUND/AIMS: Assessment of Health-related quality of life (HRQOL) outcomes in treatment of chronic disease is increasingly important. The objective of this study was to validate a Korean translation of the Liver Disease Quality of Life instrument (LDQOL version 1.0) for use in patients with chronic liver disease. METHODS: Two native Korean speakers with fluent English translated LDQOL including instructions, items, and response choices. This Korean translation of the LDQOL was administered to 121 patients with chronic liver disease. Cronbach's alpha coefficients were applied to test an internal consistency reliability of disease-specific scales of the LDQOL. MELD and modified CTP scores were calculated for all patients. Associations of MELD and modified CTP scores with severity of liver disease were analyzed with LDQOL. RESULTS: Internal consistency reliability was good (Cronbach's Alpha=0.69-0.94) in liver disease specific scales, except for the quality of social interaction scale (Cronbach's Alpha= 0.56). Mean modified CTP score and MELD score were 6.2+/-1.9 and 9.3+/-5.3, respectively. Both MELD score and modified CTP score showed correlations with most of the scores of liver disease specific scales of LDQOL 1.0, except for the quality of social interaction and sleep scale. CONCLUSIONS: The Korean version of the liver disease specific scales of the LDQOL 1.0 is validated and useful for measuring HRQOL in Korean patients with chronic liver disease.