A Study Of The Impact Of Economic Status On The Opinion Of Beneficiary Candidates Of The Scheme Of Developing High Quality Research About The Scheme Benefits

Continuous improvement and evolution in various fields are crucial to ensure a better living environment for everyone. To achieve this, researchers have a significant responsibility to produce valuable research in concerned areas. However, dedicated researchers often face various obstacles, such as financial stress, which can hinder their ability to conduct research. To support Ph.D. scholars, many central and state government funding agencies offer financial assistance schemes. In this regard, the Government of Gujarat has initiated a scheme called SHODH – ScHeme Of Developing High quality research to provide financial support to Ph.D. scholars from recognized universities/institutes of the state to produce quality research in various disciplines. However, it is essential to understand the impact of the scheme's benefits from the perspective of the beneficiary candidates, especially those belonging to different economic statuses. Therefore, a study has been conducted to explore the opinions of beneficiary candidates of the SHODH scheme about the scheme's selected aspects and whether their opinions differ based on their economic status. The study adopts a causal-comparative research method to gain insight into the requirements of research scholars belonging to different economic statuses. This information will enable better facilitation of scholars to produce meaningful research in their respective fields.

Promoting high-quality therapeutic research on nontuberculous mycobacteria pulmonary disease in China / 中华临床感染病杂志

The incidence of pulmonary disease caused by nontuberculous mycobacteria infection (NTM-PD) shows a growing trend. The treatment of NTM-PD is of low cure rate, high mortality and recurrence rate at present, it is necessary to promote the high-quality clinical therapeutic research. Based on the clinical guidelines, clinicians should carry out high-quality clinical research of NTM-PD treatment, focusing on the current urgent problems, especially the time of treatment initiation, optimization of treatment regimens, as well as prevention and rehabilitation strategies.

Research progress in quality research and evaluation of human mesenchymal stem cells / 国际生物医学工程杂志

As adult stem cells, human mesenchymal stem cells (hMSCs) have the potential for self-replication, renewal, and multidirection differentiation. Their unique biological function determines their wide clinical indications. Researchers can define the quality attributes of hMSCs according to clinical expectations. The quality study of hMSCs should consider microbiological safety, biological safety, cell biological properties, and biological effectiveness. Quality evaluation is a common physical, chemical, and biological evaluation method for hMSCs. Traditional product safety evaluation strategies cannot fully adapt to current technology and product usage characteristics. Researchers have developed new, effective evaluation methods based on current technology. In terms of product efficacy evaluation strategies, an efficacy evaluation system has been gradually established and standardized according to the intended clinical use and based on quality studies, which can enable researchers to evaluate hMSCs products more comprehensively at different stages and processes. In this paper, the progress of quality research and evaluation of human mesenchymal stem cells was reviewed to provide a reference for the utilization of stem cells in the field of regenerative medicine.

A study on quality of Paridis Rhizoma and consideration on standards of Paridis Rhizoma in Chinese Pharmacopoeia / 中国中药杂志

Thin layer chromatography, high performance liquid chromatography and multivariate statistical analysis were integrated in current study to provide a basis for the quality evaluation and the standard improvement of Paridis Rhizoma(Chinese name: Chong-lou). The results demonstrated that the primary saponins in the two authorized sources of Paridis Rhizoma were polyphyllinsⅠ, Ⅱ and Ⅶ, while the rhizome of Trillium tschonoskii an adulterant of Paridis Rhizoma was rich of polyphyllin Ⅵ. Therefore, the apparent content of polyphyllin Ⅵ plays a determinant role towards the source authentication of raw materials and decoction slices of Paridis Rhizoma, whose adulterants frequently occur in the market. Moreover, the contents of polyphyllin Ⅵ in the two authorized sources could meet the requirements of Chinese Pharmacopoeia. Therefore, we suggested that polyphyllin Ⅵ should not be omitted from the quality standard of Paridis Rhizoma in the Chinese Pharmacopoeia, and on the other side, polyphyllinsⅠ, Ⅱ and Ⅶ should be the eligible quality indicators. The study aims to sound information and evidences for the quality evaluation of Paridis Rhizoma, and also to provide a theoretical basis for the standard revision of Paridis Rhizoma in the future Chinese Pharmacopoeia.

A Unique Data Validation Process By Internal And External Quality Assurance System Aimed To Combat Research Malpractice.

Research fabrication and data fraud are one of the major concerns worldwide which are rising and evident from increasing number of retractions in peer reviewed Journals. If not checked, this can impact the reputation of a research organisation as well as the costs of translation of research data. In basic research extremely publicized cases of falsification of data have been reported and it is possible, that there are many unreported or undetected cases. In order to improve the quality standards, the validation processes were implemented for data quality at Neuroscience research lab in India for verifying PhD thesis results. Good Laboratory practices could be implicated in every research institute so that data impostures were prevented. We aimed to establish superior data quality by randomly verifying raw data in multiple projects funded by national agencies before publication of results at Neuroscience Research Lab.

Nem herói, nem vilão: elementos da prática médica na atenção básica em saúde / Neither a hero nor a villain: elements of medical practice in primary care

Resumo O artigo sistematiza e discute elementos presentes na prática médica que contribuam para uma melhor compreensão da sua reconhecida baixa adesão às diretrizes da Política Nacional de Atenção Básica (PNAB). Para tanto, fez uso de material empírico produzido em duas investigações de caráter qualitativo conduzidas pelo mesmo grupo de pesquisa. Na primeira, entrevistas feitas com dirigentes gestores e controle social de dois municípios paulistas, os médicos são apontados como explicação importante para as dificuldades de se construir uma atenção básica qualificada e resolutiva: um "médico vilão". Na segunda, utilizou-se observação direta do cotidiano em sete unidades básicas de saúde em três municípios paulistas, com registros de cenas do médico em ação e/ou quando reflete sobre seu trabalho ou quando observado pela equipe. Emerge assim um médico mais complexo, fragilizado, com instrumental reduzido para atuar perante o "social" que invade seu consultório, ameaçado em sua autonomia profissional, com dificuldade de integrar-se ao trabalho em equipe, expropriado das funções regulatórias e nem sempre com clareza do lugar reservado para a clínica na atenção básica: um médico humano, demasiado humano, nem herói, nem vilão.

Abstract This article describes the elements present in medical practice that contribute to understand its acknowledged low adhesion to the guidelines set forth by the Brazilian Primary Health Care (PHC) Policy. The empirical material produced by the two investigations of a qualitative nature led by the research team were put into use. In the first, in interviews involving managers and social control in cities the State of São Paulo, Brazil, physicians (acknowledged as central professionals for the construction of the Brazilian Unified Health System - SUS), are referred to as important assets to explain the difficulties to form a qualified primary health care service: the so-called "villain physicians." In the latter, ethnographic/cartographic research carried out in seven PHC Units in cities of São Paulo, with the use of scenes showing the doctors in action and/or thinking about their jobs, and the health team observing their work, more complex physicians emerge: fragile professionals with a reduced set of instruments to act before the "social factor" that invade their practices, threatened in their autonomy, finding it hard to engage in teamwork, dispossessed of their regulatory functions, and unaware of the space reserved for primary practices: decidedly human physicians - neither heroes nor villains.

Research Progress in Medicinal Ingredients of Ananas Comosus L. Leaves / 中国药师

Ananas comosus L. leaves,the leaves of pineapple,have a variety of medicinal values. Therefore,they can be used to prevent and treat many diseases. Pineapple leaves are actually safe that few studies have shown the side effects. The chemical composi-tion,medicinal value,toxicity and safety of pineapple leaves were summarized in the article, and the quality research was described simply as well.

A busca pela Cirurgia Bariátrica: itinerário terapêutico vivido no Serviço Público de Saúde / The Search for Bariatric Surgery: therapeutic itinerary experienced in the Public Health Service

Introdução: A obesidade é um problema de saúde pública, por isso requer que o sistema se organize para atender as pessoas que vivenciam esta situação. Ao buscar pela Cirurgia Bariátrica no Serviço Público de Saúde, a pessoa se depara com diversas escolhas que constituem a malha de itinerações do vivido. Objetivo: Compreender o itinerário terapêutico vivido no Serviço Público de Saúde pela pessoa com obesidade em busca da Cirurgia Bariátrica. Método: Pesquisa qualitativa de abordagem fenomenológica, realizada em um Hospital Público de São Paulo. Participaram deste estudo 17 pessoas com obesidade que buscaram pela Cirurgia Bariátrica no Sistema Único de Saúde, internados na clínica médico-cirúrgica, com data agendada para o procedimento. A condução das entrevistas deu-se pelas questões norteadoras: Como foi a sua procura em busca da Cirurgia Bariátrica? Quais caminhos percorreu? Como foi vivenciar esses caminhos? Durante o tempo em busca do tratamento, como foi o atendimento recebido? Como espera continuar sendo atendido? Qual é a sua expectativa para depois da cirurgia? Resultados: O típico da ação vivida no itinerário terapêutico percorrido pela pessoa com obesidade, em busca da Cirurgia Bariátrica, mostrou-se como aquela que procurou e trilhou diversos caminhos nos serviços públicos de saúde; vivenciou a morosidade do tempo de espera na fila aguardando pela cirurgia, o que contribuiu tanto para o amadurecimento e reflexão sobre a situação vivida quanto para a manutenção e/ou aumento de peso, desencadeando problemas biopsicossociais e limitações no seu cotidiano; conviveu com a ansiedade, a dor, a incerteza do futuro e até mesmo com o medo da morte; sentiu-se descuidada durante o itinerário percorrido devido à lacuna existente entre o atendimento recebido e o preconizado pelas políticas, programas e diretrizes; considerou a ajuda dos profissionais de saúde imprescindível para que conseguisse percorrer o caminho e chegar até a aprovação para a Cirurgia Bariátrica; espera melhor estrutura nas redes de atendimento, práticas de cuidado realizadas por equipe multidisciplinar capacitada e diminuição da lacuna entre o atendimento ofertado pelo Serviço Público e a situação vivida no itinerário terapêutico. Para além da Cirurgia Bariátrica almeja a possibilidade de retomar a realização de atividades simples e rotineiras, ser inserida na sociedade e poder empreender na carreira profissional. Conclusão: Ao percorrer o caminho em busca da Cirurgia Bariátrica, a pessoa com obesidade experimenta dificuldades e barreiras, que a leva a buscar e utilizar recursos que nem sempre estão disponíveis no Sistema de Saúde, mas fazem parte do itinerário percorrido. O acesso e o acolhimento das necessidades e expectativas de cuidado das pessoas com obesidade podem favorecer o aprimoramento e o incremento da qualidade dos Serviços de Saúde oferecidos. Salienta-se a necessidade de a equipe multidisciplinar compreender as especificidades da pessoa com obesidade, de modo a estabelecer e compartilhar um plano de cuidados fundamentado nos aspectos sociais e individuais e da comunidade, valorizando as circunstâncias e contextos que possam interferir no itinerário terapêutico. Capacitar a pessoa para lidar com esta doença crônica de modo responsável exige que as intervenções sejam direcionadas para a compreensão da subjetividade, com propostas voltadas para os aspectos biopsicossociais.

Introduction: Obesity is a public health problem that requires the system to organize itself so as to assist people experiencing this situation. When reaching out for bariatric surgery through the public health system, people come to face several choices that make up the set of paths taken. Objective: To understand the therapeutic itinerary taken in the Public Health Service by the person with obesity in search of Bariatric Surgery. Method: This qualitative study, using a phenomenological approach, was conducted in a public hospital in São Paulo. Study participants were 17 obese people who were candidates for a bariatric surgery through the Brazilian unified health system, and who were hospitalized in the medical-surgical clinic of the studied hospital, with a date scheduled for the procedure. Interviews were conducted following the guiding questions: How was your search for Bariatric Surgery? Which paths did you take? What was it like to experience these paths? During the time you searched for treatment, what was the service you received like? How do you expect to be served from now on? What are your expectations after the surgery? Results: The usual experience lived in the therapeutic path taken by obese people who search for a bariatric surgery was that of a person who searched and took several paths in public health services; experienced a slow waiting list for the surgery, which contributed significantly for them to become more mature and reflect on the situation experienced as regards the weight maintenance and/or gain, triggering biopsychosocial problems and limitations in their daily living; experienced anxiety, pain, uncertainty regarding the future and even fear of death; felt neglected during the path taken due to the gaps existing between the service received and that recommended in policies, programs, and guidelines; considered the help of health professionals essential to be able to take the necessary path to get to the approval of a bariatric surgery; hopes for a better structure in service networks, care practices performed by a qualified multiprofessional team and the reduction of gaps between the service offered by the public system and the situation experienced in the therapeutic path. After the bariatric surgery, these individuals expect the possibility to resume performing simple and routine activities, be inserted in society and be able to undertake in a professional career. Conclusion: When walking the path in search of Bariatric Surgery, the person with obesity experience difficulties and barriers, which lead them to search and use resources that are not always available in the Health System, but which are part of the path taken. Access and embracement of the care needs and expectations of obese people can favor an improvement and an increase in the quality of the Health Services offered. It is worth noting the need for the multiprofessional team to understand the specificities the person with obesity, so as to establish and share a care plan grounded on community, social and individual aspects, valuing the circumstances and contexts that may interfere in the therapeutic path. Interventions must be directed towards the understanding of subjectivity, with proposals considering biopsychosocial aspects, in order to qualify people to deal with this chronic disease with responsibility.

Biosimilarity Study Regarding Product Quality of Candidate Recombinant Monoclonal Antibodies as Biosimilars / 中国药学杂志

OBJECTIVE: Nowadays, recombinant monoclonal antibodies developed as biosimilar domains in application category for Investigational New Drug in domestic. The quality similarity should be prequalified for candidate drug to be developed as biosimilar. Here, the concept of quality biosimilarity was proposed and discussed from reviewer as well as developer. METHODS: The challenge of developing and evaluating biosimilar antibodies was emphasized. Then, the domestic sponsor's common problems were sorted out and critical quality attributes of some originator antibodies were summarized. Lastly, the reasons of holding letter or case rejected were exemplified and analyzed. RESULTS: AND CONCLUSION: The sponsor are encouraged to conduct comparing exercise by state-of-art analytical technologies to conform the quality similarity between a proposed biosimilar antibody and the originator product, the reviewers should also be very cautious to assess quality differences. Joint efforts and effective communication from researcher and reviewer are critical for promoting development of domestic biosimilar and addressing the unmet medicine need.

General considerations of quality study for biosimilar products containing recombinant monoclonal antibodies / 中国药学杂志

OBJECTIVE: Different from new drug application, research on biosimilar products mainly focuses on similarity in quality as well as equivalence or non-inferiority in clinical application compared to reference products. Quality research on biosimilar products is one of the most important research fields, for not only it is the main work to secure the safety, efficacy and quality of the products, but also it is the key point that would determine whether the products could follow the requirements for development of biosimilar products.

Novas possibilidades metodológicas: a quebra dos paradigmas qualitativo e quantitativo em psicologia / Nuevas posibilidades metodológicas: la ruptura de los paradigmas cualitativos y cuantitativos en psicología / New methodological possibilities: rupture of qualitative and quantitative paradigms in psychology

O presente relato propõe uma metodologia materialista dialética de análise de dados que rompe com os paradigmas qualitativos e quantitativos, numa perspectiva transdisciplinar e complexa, tomando como categorias analíticas historicidade, identidade, narcisismo, efemeridade e transitoriedade. Relata-se o caso "O Climatério na Contemporaneidade", que utilizou discursos e escalas padronizadas. Nos resultados, construiu-se uma articulação entre os vários tipos de dados, a partir de uma análise estatística fatorial e de cluster para revelar tanto as semelhanças, quanto as diferenças entre as mulheres pesquisadas, além da formação de grupos qualitativos, de forma não arbitrária ou tendenciosa, baseada nas impressões dos pesquisadores. Demonstra-se criatividade metodológica que contempla a complexidade do objeto, ao construir um caminho metodológico original, baseado no pensamento dialético, que abarca tanto a diversidade quanto a totalidade do fenômeno, demonstrando que qualidade e quantidade, objetividade e subjetividade são duas faces de uma mesma moeda...

Se propone un método materialista dialéctico de análisis de datos que rompe con los paradigmas cualitativos y cuantitativos, en una perspectiva transdisciplinaria y compleja, teniendo como categorías analíticas historicidad, identidad, narcisismo, efimeridad y transitoriedad. Presentamos el caso "El climaterio en la contemporaneidad", que utiliza discursos y escalas estandarizadas. En los resultados, hemos construido un vínculo entre los distintos tipos de datos, a partir de un análisis factorial y cluster para revelar similitudes y diferencias entre las mujeres encuestadas, además, la formación de grupos cualitativos, de forma no arbitraria o sesgada, basada en las impresiones de los investigadores. Se muestra creatividad metodológica, que incluye la complejidad del objeto, para construir un enfoque metodológico único, basado en el pensamiento dialéctico, que tanto abraza la diversidad como el fenómeno en su totalidad, lo que demuestra que la calidad y la cantidad, la objetividad y la subjetividad son dos caras de la misma moneda...

This report proposes a dialectic method of data analysis that breaks with the qualitative and quantitative paradigms in a complexity and transdisciplinary perspective taking as analytic categories historicity, gender relations, identity, narcissism, ephemerality and transitority. To illustrate this construction it is reported the case, "The Climacteric in Contemporary," which used standardized scales and speeches. In the analysis we constructed a linkage between the various types of results from a factor analysis and cluster to reveal both similarities and differences between the women surveyed, besides the formation of groups qualitative without being arbitrary or biased based the impressions of researchers. It is shown that creativity involves the methodological complexity of the object studied by building a unique methodological approach, based on dialectical thinking, which includes both the diversity as the totality of the phenomenon, showing that the quantity and quality and objectivity and subjectivity are two sides of a same phenomenon...