Application of Quantitative Ultrasound in Evaluation Skeletal Development of Children and Adolescents / 实用儿科临床杂志

Objective To study the clinical application of quantitative ultrasound(QUS) which evaluate skeletal status of children and adolescents.Methods Subjects were children and adolescents aged 0-18 years old.Tibia/radial bone strength was obtained using QUS.Children who were younger than 2 years old only were measured at midpiece of tibia,and children who were older than 2 years old were measu-red at midpiece of tibia and radius.At the same time,calcium in peripheral blood was measured by the method of atomic absorption.Results 1.Radial and tibial bone strength presented nonlinear growth with age in healthy children and adolescents.2.Bone strengths of different anatomic-sites were different and the disparity rate of evaluation at different anatomic sites was 30.1%.3.The bone strength of the children who had some risk factors that could induce decrease of bone strength or had some diseases of bone metabolism was lower than healthy children.Composition of low bone strength children was 71.1% in high risk children,and was 47.9% in those who had some symptom or physical sign of calcium deficiency.4.Composition of low bone strength children was 44.2% in those who had normal peripheral blood calcium,and composition of normal bone strength children in those who had low peripheral blood calcium was 59.7%.The 2 methods had no correlation.Conclusions QUS is a quite useful technique in evaluation skeletal status of children and adolescents,and is sensitive for high risk children.It is necessary to measure radius and tibia,and consider blood calcium and bone strength to evaluate practical level of calcium and nutritional state of children.

No relationship between single nucleotide polymorphisms of vitamin D receptor gene and bone mass in Tibetan women / 中华内分泌代谢杂志

The single nucleotide polymorphisms (SNP) of vitamin D receptor (VDR) gene were determined by BsmI restriction endonuclease analysis and quantitative ultrasonography indexes (QUI) of calcaneum were measured in Tibetan women. The results showed that there were no statistical differences between QUI of different genetypes and between distribution frequencies of gene types in young women and menopausal women. And it was found that the SNP of VDR by BsmI restriction endonuclease analysis was not relevant to bone mass acquisition and rate of bone mass loss.