ABSTRACT
【Objective】 To explore the research status, hotspots, development trend and frontier of RBC storage lesion. 【Methods】 The Web of Science core collection database (http: //webofscience.com) was used to retrieve the documents related to " red blood cell storage lesion" from 2005 to 2021. After the exclusion of unrelated documents, CiteSpace (CiteSpace.5.7.R2) was used for bibliometric analysis, including author (all signatories of the article), institution and country (to which the article is affiliated), journal, key words and cited literatures. 【Results】 A total of 508 literatures were included, accounting for 91.86% (508/553) of all publication concerning " RBC storage lesion" in this period. The annual growth rate of publications was 14.38%. There were 1 868 authors totally, and 39.76% (202/508) of them published more than 3 papers. D ′Alessandro A from the United States ranked first [7.68% (39/508)], Univ Colorado System and Univ Pittsburgh were the top two institutions [7.28% (37/508) and 7.09% (36/508), respectively]. The United States [53.35% (271/508)], Canada [13.19% (67/508)], the United Kingdom [6.50% (33/508)] and Switzerland [6.10% (31/508)] were the top 4 countries. Keywords co-occurrence network, emergent atlas and literature co-citation cluster atlas mainly focused on mechanism research, clinical trials, improvement of RBC storage conditions and reduction of RBC storage lesion. 【Conclusion】 The most important researchers and institutions in the field of RBC storage lesion in the past 17 years were mainly from the United States and Europe. The application of metabolomics and other technologies, the mechanism of RBC storage lesion, the selection of donor diversity, and the research and development of new preservation solutions or additives are the hotspots and frontiers in this field.