ABSTRACT
Rabbit Syndrome is an uncommon side effect of antipsychotic treatment. Although it is usually associated with typical antipsychotics, it can also be related to atypical antipsychotics. Anticholinergics are the most accepted treatment approach in treating Rabbit Syndrome. Fluvoxamine is a member of selective serotonin reuptake inhibitors and it is a potent agonist of sigma 1 receptors. In this article, we report a Rabbit Syndrome case who has benefited from fluvoxamine, in terms of both depressive disorder and Rabbit Syndrome; and present the data on the effects of sigma 1 agonist fluvoxamine on numerous movement disorders.
Subject(s)
Antipsychotic Agents , Cholinergic Antagonists , Depressive Disorder , Fluvoxamine , Movement Disorders , Receptors, sigma , Selective Serotonin Reuptake InhibitorsABSTRACT
We report a case of rabbit syndrome in a 28-year-old man with chronic active epilepsy and mental retardation. He developed fine and rhythmic perioral involuntary movements with mild parkinsonism several months after he had been administered with neuroleptics. His movements had a rhythmic pattern consisting of 2-3 Hz with a resting period for 1- 2 seconds. They were remarkably reduced with benztropine. Parkinsonism also improved with benztropine.
Subject(s)
Adult , Humans , Antipsychotic Agents , Benztropine , Dyskinesias , Epilepsy , Intellectual Disability , Parkinsonian DisordersABSTRACT
A 50 year old man presented with mouth and tongue tremor for 6 months. He lead no previous exposure to any narcoleptic drugs. Physical examination revealed healthy except abnormal movement of his mouth and tongue without any signs of parkinsonism. Investigations s howled normal blood chemistry profile, chest radiography, electrocardiography and electro encephalopathy. Benztropine 2 milligram three times a day was prescribed for him and he responded dramatically within a few days and all symptoms were disappeared within two weeks. He was a regular attendant to our Movement Disorder Clinic at Siriraj Hospital for 4 consecutive years without any evidence of parkinsonism signs. He once stopped medication by his own for 2 weeks and movement disorder of rabbit syndrome recurred but all his symptoms were controlled after read ministration of benztropine. This is the first report of rabbit syndrome in Thailand with spontaneous occurring and tongue tremor. Now only 30 reported cases were in the world literature.