ABSTRACT
OBJECTIVE:To investigate the protective effect of Radix Paeoniae Rubra Extracts on rats with experimental cerebral ischemia.METHODS:Middle cerebral artery occlusion(MCAO)model was prepared in rats by thread-blocking internal carotid artery,and the model rats were intragastrically administered with different doses of Radix Paeoniae Rubra Extracts with the protective effect of Radix Paeoniae Rubra Extracts monitored.Cerebral infarction tissue,brain hndex and abnovmal nevons symptoms were observed.RESULTS:The weight of cerebral infarction tissue of the MCAO rats was decreased significantly by Radix Paeoniae Rubra Extracts dose-dependently in the dose ranges of 240,120,60 and 30 mg?kg-1.Radix Paeoniae Rubra Extracts could also decrease brain index and improve abnormal nervous symptoms in MCAO rats.The preventive medication of Radix Paeoniae Rubra Extracts has significantly lowered the weight percent of cerebral infarction tissue in MCAO rats,assuming dose-dependent manner in the dose range of 240～30 mg?kg-1,decreased the brain index and significantly improved the abnormal nervous symptoms of MCAO rats.CONCLUSION:Radix Paeoniae Rubra Extracts have protective effects on cerebral ischemia in MCAO model rats.