ABSTRACT
Las radiografías dentales son necesarias para diagnosticar y hacer seguimiento de múltiples enfermedades orales. Sin embargo, debido a los conocidos efectos estocásticos de los rayos X dentales es imprescindible garantizar protección a los pacientes. Especial atención merecen las mujeres embarazadas por cuanto el feto es altamente vulnerable a la radiación, sobre todo enlas primeras semanas. Algunas recomendaciones de protección radiológica en esta población son: El uso de radiografías ha sido justificado; realizar el estudio 10 días después del inicio de la menstruación; informar del procedimiento a la embarazada a fin de evitar el miedo; optimizar el procedimiento (haz colimado, alto kVp, control manual de disparo, calibración regular etc.) y usar delantal plomado solo si las condiciones de optimización son insuficientes
Dental x-rays are necessary to diagnose and monitor multiple oral diseases. However, due to the well-known stochastic effects of dental X-rays, it is essential to guarantee patient protection. Pregnant women deserve special attention because the fetus is highly vulnerable to radiation, especially in the first weeks. Some recommendations for radiological protection in this population are the use of radiographs has been justified; conduct the study 10 days after the onset of menstruation; inform the pregnant woman about the procedure to avoid fear; optimize the procedure (collimated beam, high kVp, manual trip control, regular calibration etc.) and use a lead apron only if the optimization conditions are insufficient.
ABSTRACT
PURPOSE: To observe and evaluate the effects of Simvastatin-induced osteogenesis on the wound healing of defective bone. MATERIALS AND METHODS: 64 defective bones were created in the parietal bone of 32 New Zealand White rabbits. The defects were grafted with collagen matrix carriers mixed with Simvastatin solution in the experimental group of 16 rabbits and with collagen matrix carriers mixed with water in the controlled group. The rabbits were terminated at an interval of 3, 5, 7, and 9 days, 2, 4, 6, and 8 weeks after the formation of defective bone. The wound healing was evaluated by soft X-ray radiography. The tissues within defective bones were evaluated through the analysis of flow cytometry for the manifestation of Runx2 and Osteocalcin, and observed histopathologically by using H-E stain and Masson-Trichrome stain. RESULTS: 1. In the experimental group, flow cytometry revealed more manifestation of Runx2 at 5, 7, and 9 days and Osteocalcin at 2 weeks than in the controlled groups, but there was few difference in comparison with the controlled group. 2. In the experimental group, flow cytometry revealed considerably more cells and erythrocytes at 5, 7, and 9 days in comparison with the controlled group. 3. In the experimental group, soft x-ray radiography revealed the extended formation of trabeculation at 2, 4, 6, and 8 weeks. 4. histopathological features of the experimental group showed more fibroblasts and newly formed vessels at 5 and 7 days, and the formation of osteoid tissues at 9 days, and the newly formed trabeculations at 4 and 6 weeks. CONCLUSION: As the induced osteogenesis by Simvastatin, there was few contrast of the manifestation between Runx2 and Osteocalcin based on the differentiation of osteoblasts. But it was considered that the more formation of cells and erythrocytes depending on newly formed vessels in the experimental group obviously had an effect on the bone regeneration.