Safety of a 90-min duration of intravenous infusion of obinutuzumab in patients with B-cell non-Hodgkin's lymphoma in a tertiary hospital in China: a prospective, open-label, exploratory clinical trial

This study aimed to analyze the safety and applicability of a 90-min duration of infusion (SDI) of obinutuzumab in patients with B-cell non-Hodgkin's lymphoma (NHL) in a tertiary hospital in China. This exploratory clinical trial was performed at Jiangsu Province Hospital. All patients were treated with the standard infusion regimen for the first infusion. If no grade ≥3 infusion-related reactions (IRRs) occurred, the subsequent infusions were given as SDI. The primary endpoint was the incidence of IRR during the standard infusion (3-4 h) and 90-min SDI regimens. This study enrolled 208 patients and all completed cycle 1. Forty-one patients (19.71%) had IRRs: five (2.40%) with grade 1, twenty-eight (13.46%) with grade 2, and eight (3.85%) with grade 3. The 41 patients had 71 IRRs, mainly fever (40.85%), chest pain/tightness (12.68%), and dyspnea (9.86%). The occurrence of IRRs in the first infusion was significantly lower in patients who received oral acetaminophen prophylaxis than those who did not (10.72% vs 30.21%, P<0.001). For the subsequent cycles with 90-min SDI, only two (0.25%) IRRs occurred among 814 infusions (one grade 1 hand numbness and one grade 2 chill/fever). The 90-min obinutuzumab SDI might be safe and feasible in patients with B-cell NHL in China.

"The specialty and coping strategies of ""ShenZhou 11"" astronauts' rescue and medical aid" / 中华急诊医学杂志

Objective To ensure the medical security of the astronauts,new targeted strategies were adopted after summarizing the experience in Chinese astronauts rescue and medical aid at the main landing site,the specialty and characteristics of landing were analysied.Methods Search the publications about astronaut medical aid domestic and abroad,summarize the rescue and medical aid experiences from Shenzhou 5 to Shenzhou 10.In consideration of prolonged on-orbit time,the cold weather conditions at the landing zone of Shenzhou 11,new targeted strategies were presented.Results On the basis of the original helicopter emergency platform and first aid equipment,the emergency aid procedures were optimized,personal warm clothing,a heat preservation box,insulation blanket,self-heating pads and intraosseous rapid infusion system were used to ensure the medical security of astronauts in cold weather at the main landing site.Conclusions With the procedures optimized and the targeted strategies performed,the astronauts' s rescue and medical aid project was fully meet the cold and complex conditions at main landing site.

Analysis in the Use of Rapid Infusion System for 14 Patients / 대한마취과학회지

BACKGROUND: Inadequate infusion flow rates and hypothermia are significant problems encountered in managing hypovolemic shdegrees Ck secondary to intraoperative or traumatic hemorrhage. The rapid infusion system(Haemonetics corporation., U.S.A., RIS) allows normothermic volume restoration at flow rates of up to 2000 ml/minute when two 10 gauge catheters are used. METHODS: From June 1996 to January 1997, we used RIS in 14 patients who expected to develop or had developed hemorrhagic hypovolemic shdegrees Ck and a retrospective clinical study was undertaken in these patients. Statistical significances (p<0.05) were analyzed by two-tailed Student's t-test. RESULTS: 1) There were 3 liver transplantation patients, 8 traumatic hypovolemic shdegrees Ck patients and 3 hypovolemic shdegrees Ck patients who underwent elective abdominal surgery. 2) Total fluid infused through RIS averaged 40.5+/-32.5(4~100) units of packed red cells, 22.9+/-21.8(3~82) units of fresh frozen plasma, and 16292.9+/-15382.4 ml of crystalloid. 3) In 8 traumatic hypovolemic shdegrees Ck patients, (1) The initial Emergency Department Trauma Score(TS) averaged 10.6+/-3.5 and initial operating room APACHE III score averaged 63.8+/-27.6. (2) The average preoperative systolic blood pressure was 77.5+/-28.7 mmHg, pulse rate was 119.6+/-10.2 beats/min. and body temperature averaged 34.5+/-2.2 degrees C. (3) Corresponding postoperative values were 111.4+/-12.5 mmHg, 110.7+/-20.1 beats/min and 35.8+/-1.5 degrees C. (4) The average preoperative prothrombin time was 16.4+/-2.4 sec, activated partial thromboplastin time was 53.0+/-31.2 sec and platelet count was 129.6+/-82.6( 103/microliter). (5) Corresponding postoperative values were 21.7+/-9.7 sec, 68.7+/-29.2 sec and 25.8+/-24.2( 103/microliter). (6) Changes for both systolic blood pressure and platelet count were statistically significant. (p<0.05) (7) Mortality rate was 1/8 at twenty-four hours and 3/8 overall. CONCLUSIONS: The rapid infusion system can be effectively employed in patients who expected to develop or had developed hemorrhagic hypovolemic shdegrees Ck. In 8 traumatic hypovolemic shdegrees Ck patients, there were no significant complications except thrombdegrees Cytopenia after RIS use, and, the mortality rate was 12.5% at twenty-four hours and 37.5% overall.

Anesthesia for Liver Transplantation / 대한마취과학회지

We experienced one case of anesthesia for liver transplantation in 32-year-old male patient with liver cirrhosis. The liver donor was 27-year-old male patient who was diagnosed brain death due to car accident. The operation was finished successfuly for 12 hours with intensive monitoring and treatrnent with using TEG and RIS. Patient was transfered to ICU after operation with intubated state. Extubation was done 2 days after operation and patient discharged without complication about 2 months later.