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OBJECTIVE To analyze the occurrence of adverse drug reactions （ADR） between bevacizumab biosimilars and original drugs， and to provide data support for rational use of drugs in clinical. METHODS ADR reports of bevacizumab biosimilars and original drugs reported by Jiangsu Cancer Hospital from January to December 2022 were retrospectively analyzed. RESULTS A total of 6 818 patients were treated with bevacizumab， and 136 ADR patients were reported. The incidence of ADR caused by bevacizumab biosimilars was higher than original drugs （2.18% vs. 0.71%， P＝0.004）. In ADR reports， the main treatment plan was bevacizumab combined with other tumor drugs （129 patients）； 118 patients were cured and improved； there were 108 general reports and 28 serious reports； the main system/organ involved in ADR was the cardiovascular system； there were no statistical significance in the incidence rates of hypertension/blood pressure increase， leukocyte/platelet decrease， diarrhea and fever caused by bevacizumab biosimilars and original drugs. CONCLUSIONS The incidence of ADR related to bevacizumab biosimilars is significantly higher than that of the original drugs， but there is no significant difference in the clinical manifestation of ADR. Clinicians can use bevacizumab biosimilars or original drugs based on the willingness of patients and their families.
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With the mutual communication and penetration of traditional Chinese medicine and modem medicine,the combination of traditional Chinese and western medicine is common in clinical practice.However,since western-style doctor is usually lack of traditional Chinese medicine theory knowledge,many problems exist in the combination of Chinese and western medicine.The problem that Chinese medicine containing ephedra alkaloids in combination with western medicine in pediatric medicine is especially serious.Because of the complexity of the children's drugs,improper use of the ephedra alkaloids is prone to adverse reactions.A comprehensive analysis of drugs containing ephedra alkaloids existing in the pediatric clinical application is performed,and in order to provide guidance for clinical rational drug use.
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Objective To analyze the proprietary Chinese medicine adverse reaction(ADR),thus to promote rational drug use in clinical.Methods According to clinical physicians,nurses and pharmacists fill in drug ADR reports,collected 48 cases of proprietary Chinese medicine ADR reports in our hospital during 2012-2015.The patients'age,sex,adverse reactions and drug varieties and aspects and so on,involved organs or systems,the prognosis were analyzed.Results According to the age distribution,children under the age of 10 years had 24 cases (50.00％).According to the varieties of drug,Reduning injection caused adverse reaction was up to 25 cases (52.08％).Damage to one of the most common clinical manifestations in the skin and accessories,a total of 29 cases (60.42％).Conclusion We should pay attention to the ADR of Chinese medicines,strengthen the monitoring analysis of daily work,avoid or reduce ADR,the clinical use of Chinese patent medicine is more safe and reasonable.
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Objective To reduce unreasonable use of antibiotics in acute suppurative tonsillitis cases. Methods Retrospective analyses of 1107 acute suppurative tonsillitis cases from the pediatric outpatient department were conducted.According to course of antibiotic treatment, these cases were divided into the group of full course of treatment and the group of insufficient course of treatment.According to the types of antibiotic, the subjects were di-vided into azithromycin group and non-azithromycin group.Three months after the onset of illness, the occurrence of complications and illness relapse between full course of treatment group and insufficient course group, azithromycin group and non-azithromycin group were analyzed.Meanwhile, the cases were divided into Chinese mainland group, Macao and Taiwan group, and foreign group according to their native places and nationalities.We compared the num-ber of cases used insufficient course in these three groups and analyzed their reasons.Results The relapse rate was significantly lower in the full course treatment group compared with insufficient course treatment group ( P<0.05 ) , and significantly higher in non-azithromycin group compared with azithromycin group ( P<0.05 ) .The occurrence rate of insufficient course treatment in the Chinese mainland group was obviously higher than the Macao group, Tai-wan group and foreign group (P<0.05).The main reasons for insufficient course of treatment were the insufficient patients′obedience and some doctors′poor understanding of the disease course.Conclusion A full course treatment with antibiotics on acute suppurative tonsillitis are strongly suggested.It may be of great significant to strengthen the awareness of reasonable use of antibiotics among the inland citizens.
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The key of hospital fast development is how to foster and use the talented persons,cause the hospital outstanding talent to be blooming,and form the situation which enables each person to develop his talents.The author thought that the following several points should be paid attention to:①full ensuring hospital personnel training mentality,②taking effective action and establishing the personnel training mechanism,③reasonably using and enabling eash person to develop his talents.
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OBJECTIVE:To seek an effective starting point for the improvement of pharmacy administration efficiency(PAE)in China.METHODS:Level of PAE in China,the existing problems and their root causes were analyzed using a systematic methodology.RESULTS&CONCLUSIONS:Level of PAE in China is far from perfect,which may be attributed to the narrowly defined boundary of pharmacy administrating system,the lack of systematic understanding and command of relevant factors and the unscientific,non-integrated objective of pharmacy administration.It is advisable to enlarge system boundary,adjust the objective of pharmacy administration,and adopt a systematic point of view and methodology in the practice of pharmacy administration.