ABSTRACT
The purpose of this research was to find out the growth performance of albino rats orally administered with honey from Apis mellifera adansonii and refined granulated sugar at varying quantities. Twenty-five (25) healthy albino rats used in the study were grouped into five treatments based on the dose of natural honey and granulated sugar as follow: T1 (1.02g of honey kg BW), T2 (1.40g of honey kg BW), T3 (1.02g of granulated sugar kg BW), and T4 (1.40g of granulated sugar kg BW). However, rats in T5 were not administered honey and refined granulated sugar hence served as the control. The data on fructose and micronutrients concentrations of natural honey and refined sugar as well as data on the weight gain and feed intake of the albino rats were determined after 28 days. According to the findings of this study, the fructose concentration was higher in natural honey (195.78mg/ml) while refined sugar (30.225mg/ml) recorded the least value. Also, copper (0.15ppm) and manganese (0.05ppm) had the highest mean concentration in natural honey, while iron (0.04ppm) and zinc (0.07ppm) were higher in refined sugar. The study's findings revealed that the highest feed intake by albino rat was recorded in T1 (148.16g) while T5 (140.27g) had the least. There were no significant differences in albino rat feed intake among the five treatments (p>0.05). The highest weight gain was recorded by the albino rat in T1 (69.84g) while T5 (32.28g) had the least. There were no significant differences in the weight gain of the albino rats among the five treatments. This study's findings led to the conclusion that the doses of natural honey used did not significantly increase the weight gain of albino rats.
ABSTRACT
Introducción: la sacarosa es un producto natural que por sus propiedades se considera bacteriostática, bactericida y estimulante de la cicatrización. En el mercado mundial la venta de medicamentos y otros productos está dominada por los monopolios, por lo que se hace necesario evaluar un producto barato, capaz de disminuir importaciones y que se pueda generalizar su empleo. Objetivos: evaluar la magnitud de la epitelización total de las heridas e identificar las acciones de la sacarosa sobre los grados de maduración de la dermis. Métodos: se realizó un estudio clinicoterapéutico aleatorizado, controlado y no enmascarado en ratas Wistar con lesiones de piel provocadas e infectadas, que permitiera evaluar, desde el punto de vista histológico, los resultados del tratamiento con sacarosa de las heridas infectadas. Resultados: la sacarosa resultó efectiva para curar la infección de las heridas y estimular la cicatrización. Se produjo la completa epitelización de las heridas con seis días de antelación, con respecto a los grupos controles. Con la sacarosa se logró una mejor calidad en la cicatrización al alcanzar un mayor número de heridas el grado III de maduración de la dermis. Conclusiones: se demostró un mejor efecto cicatrizante del azúcar. Se comprobó su actividad antimicrobiana por la capacidad de limpiar las heridas y eliminar el tejido necrótico de estas. Se logró un mayor grado de maduración de la dermis en los animales tratados con azúcar, lo que evidencia una mayor calidad en la cicatrización en las heridas tratadas con azúcar.
Introduction: sucrose is a natural product that is considered for its bacteriostatic, bactericidal and stimulating healing characteristics. On the world market the sale of drugs and other products is dominated by monopolies, so it is necessary to evaluate an inexpensive alternative, which is able to reduce imports and which can be generally used. Objectives: to assess the extent of total wound epithelialization and to identify sucrose actions on the dermis maturation degrees. Methods: a clinical therapeutic randomized, controlled, unblinded study was performed in Wistar rats with induced infected skin lesions and, to assess the histological results of sucrose treatment of infected wounds. Results: sucrose was effective in curing the infection in wounds and in promoting healing. There was complete wound epithelization six days in advance, in comparison with the control groups. better healing quality was achieved to reach with sucrose since a greater number of injuries reached grade III of dermis maturing. Conclusions: better healing effect of sugar was demonstrated, as well as its antimicrobial activity due to its ability to clean wounds and to remove necrotic tissue. Higher degree of dermis maturation was achieved in those animals treated with sugar, which shows higher quality of healing in wounds treated with sugar.