Application progress of immunosuppresive agent in refractory nephritic syndrome in children / 国际儿科学杂志

Refractory nephrotic syndrome(RNS) is one of the main causes of end-stage renal disease to children and also a difficult issue in clinic treatment.In recent years,the emergence of new immunosuppresive agents greatly improved the prognosis of children with RNS.In this paper,the application progress of immunosuppresive agents such as cyclophosphamide,ciclosporin,tacrolimus,mycophenolate mofetil,leflunomide and rituximab which were commonly used in recent years to different types of children with RNS are summarized.

Effect and clinical significance of Tacrolimus on serum interleukin-2(IL-2),soluble interleukin-2 receptor(sIL-2R) expression in refractory nephrotic syndrome / 中国免疫学杂志

Objective:To investigate the effect of Tacroliums(FK506) on the significance of IL-2 and sIL-2R expression in refractory nephrotic syndrome. Methods: The expression of IL-2 and sIL-2R were evaluated by enzyme-linked immunosorbent assay (ELISA) on both pretreatment and post-treatment groups, and supervise the changes of 24hours urinary protein,serum albumin and lipid. Results:Serum IL-2 and sIL-2R level were higher in pre-treatment group than in normal control group(P