As dobras do origami: reflexões sobre a implicação em pesquisa / The origami's folds: reflections about the implication in research / Los pliegues del origami: reflexiones sobre la implicación en investigación

INTRODUÇÃO: A análise da implicação na pesquisa se opõe a uma suposta neutralidade resultante do afastamento do objeto, porque o/a pesquisador/a coloca a sua subjetividade em análise, o contexto histórico-social da pesquisa, assim como, a intersubjetividade de todos os envolvidos nela. A implicação integra o processo de construção do conhecimento na busca de maior compreensão dos fenômenos, sendo um dos conceitos fundamentais da psicossociologia. OBJETIVO: O presente estudo objetiva apresentar um relato de experiência sobre a análise da implicação em uma pesquisa clínico-qualitativa respaldada teórico-metodologicamente pela psicossociologia francesa e psicodinâmica do trabalho. Essa investigação ocorreu entre 2018 e 2022, tendo se dado parcialmente no período da pandemia da COVID-19. METODOLOGIA: Empregaram-se os seguintes dispositivos como método de análise da implicação: os diários de campo, as supervisões, as reuniões de equipe, a participação em um grupo de convivência e a psicoterapia individual. Assim, a pesquisadora procurou abordar os seus afetos e sentimentos envolvidos ao longo das etapas da pesquisa. RESULTADOS E DISCUSSÃO: Foi possível, pois, evidenciar a implicação como fonte, paradoxalmente, de processos criativos e, em alguns casos, também de alienação. CONCLUSÃO: Apesar da identificação de alguns destes aspectos negativos da implicação da pesquisadora, se pode ampliar o conhecimento sobre o objeto da pesquisa.

INTRODUCTION: The implication analysis is opposed to a supposed neutrality because the researcher analyzes his own subjectivity, his historical and social context, as well as the intersubjectivity of the actors involved in a research. Implication analysis is one of the fundamental concepts of psychosociology. It enables one to understand phenomena and builds knowledge. OBJECTIVE: The present study aims to present an experience report about an implication analysis of a clinical-qualitative research that was based on French psychosociology and psychodynamics of work theory and methodology. This investigation happened from 2018 to 2022, partially carried out during the COVID-19 pandemic. METHOD: There were used the following resources to access the implication analysis: dailies, supervisions, team meetings, participation in a reflection group, and individual psychotherapy. Thus, the researcher related feelings and affections involved in each one of the research stages. RESULTS AND DISCUSSION: This study highlighted the implication as a source that paradoxically allows creative processes but also, in some cases, alienation. CONCLUSION: Despite some negative aspects of the implication researcher, it was possible to expand the knowledge about the research object.

INTRODUCCIÓN: El análisis de la implicación en la investigación se opone a una supuesta neutralidad resultante de la distancia del objeto porque el investigador analiza su propia subjetividad, el contexto histórico-social de la investigación, así como la intersubjetividad de todos los involucrados en la investigación. La implicación forma parte del proceso de construcción del conocimiento en la búsqueda de una mejor comprensión de los fenómenos, siendo uno de los conceptos fundamentales de la psicosociología. OBJETIVO: Este estudio tiene como objetivo presentar un relato de experiencia sobre el análisis de la implicación en una investigación clínico-cualitativa sustentada teórica y metodológicamente por la psicossociologia francesa y la psicodinámica del trabajo. Esta investigación se llevó a cabo entre 2018 y 2022, habiéndose realizado parcialmente durante el período de la pandemia de COVID-19. MÉTODO: Se utilizaron como método de análisis de la implicación los siguientes dispositivos: diarios de campo, supervisiones, reuniones de equipo, participación en un grupo de convivencia y psicoterapia individual. Así, la investigadora buscó abordar sus afectos y sentimientos involucrados a lo largo de las etapas de la investigación. RESULTADOS Y DISCUSIÓN: Este estudio destacó la implicación como fuente, paradójicamente, de procesos creativos y, en algunos casos, alienación. CONCLUSIÓN: A pesar de la identificación de algunos de estos aspectos negativos de la implicación de la investigadora, se logró ampliar el conocimiento sobre el objeto de investigación.

Bibliotecários e os desafios da Ciência Aberta: habilidades, recursos e serviços / Librarians and the challenges of Open Science: skills, resources and services / Bibliotecarios y los desafíos de la Ciencia Abierta: habilidades, recursos y servicios

Este estudo tem como objetivo identificar, na literatura científica, produtos e serviços desenvolvidos por bibliotecários vislumbrando as práticas de Ciência Aberta. A questão principal é identificar: qual o papel dos bibliotecários frente aos desafios da Ciência Aberta? Predominantemente qualitativa, esta pesquisa pode ser caracterizada como bibliográfica, exploratória e descritiva. Para atingir seu objetivo, utilizou-se a técnica de revisão rápida de literatura. Foi realizado um levantamento de publicações indexadas na Brapci, na Scopus e na Web of Science, sendo recuperadas três publicações em cada. Ao excluir um título que se repetiu, o corpus da pesquisa configurou-se com seis artigos e dois resumos apresentados em evento. Conclui-se que debates sobre o novo modus operandi de fazer ciência vêm aumentando e os bibliotecários parecem intimamente relacionados às ações de Ciência Aberta nas diversas etapas da pesquisa científica. Devido às suas habilidades e aos seus serviços, entende-se que exercem um dos papéis centrais na concretização da abertura da ciência.

This study aims to identify, in the scientific literature, products and services developed by librarians with a view to Open Science practices. The main question is to identify: what role is played by librarians facing the challenges of Open Science? Predominantly qualitative, this research can be characterized as bibliographic, exploratory, and descriptive. To achieve its objective, a rapid literature review technique was used. A survey of publications indexed in Brapci, Scopus and Web of Science was carried out, and three publications from each were retrieved. After excluding one title that was repeated, the research corpus consisted of six articles and two abstracts presented at an event. We conclude that debates about the new modus operandi of doing science have been increasing and librarians seem closely related to Open Science actions in the various stages of scientific research. Because of their skills and services, they play one of the central roles to achieve the opening of science.

Este studio tiene como objetivo identificaren la literature científica los productos y servicios desarrollados por los bibliotecarios com vistas a las prácticas de la Ciencia Abierta. La cuestión principal es identificar: ¿ cuál es el papel de los bibliotecarios ante los desafíos de la Ciencia Abierta? Predominantemente cualita-tiva, esta investigación puede caracterizar se como bibliográfica, exploratoria y descriptiva. Para lograr su objetivo, se utilizó la técnica de revision rápida de la literatura. Se realizó un estudio de las publicaciones indexadas en Brapci, Scopus y Web of Science, recuperándo se tres publicaciones en cada una de ellas. Al excluir un título repetido, el corpus de la investigación quedó configurado con seis artículos y dos resúmenes presentados en un evento. Concluimos que los debates sobre el nuevo modus operandi de hacer ciencia han aumentado y los bibliotecarios parecen estar estrechamente relacionados con las acciones de la Ciencia Abierta en las distintas etapas de la investigación científica. Por sus habilidades y servicios, se entiende que ejercen uno de los papeles centrales en la realización de la Ciencia Abierta.

Consideraciones Éticas y Académicas sobre el Uso de Inteligencia Artificial en Cursos de Metodología de la Investigación en Rehabilitación / Ethical and Academic Reflections on the Integration of Artificial Intelligence in Research Methodology Courses in Rehabilitation Science

En el cruce entre la revolución tecnológica y la educación en ciencias de la rehabilitación y del movimiento humano, la inteligencia artificial (IA) emerge como herramienta transformadora en los cursos de metodología de investigación. Este artículo destaca su potencial para optimizar la experiencia de aprendizaje y personalizar la instrucción, pero enfatiza la necesidad crucial de abordar desafíos éticos y pedagógicos. Propone orientaciones para equilibrar la innovación educativa y la responsabilidad académica, resaltando la importancia de la implementación consciente y planificada de la IA en los equipos de investigación en ciencias de la rehabilitación y del movimiento humano, garantizando así la integridad científica y ética en este campo en constante evolución.

In the intersection between technological advancements and education in rehabilitation science, artificial intelligence (AI) emerges as a transformative tool in research methodology. This article navigates the ethical and academic considerations tied to the incorporation of AI in rehabilitation and movement science courses. While acknowledging its potential to enhance learning experiences, it critically addresses the imperative to tackle ethical and pedagogical challenges. The paper offers guidance to strike a balance between educational innovation and academic responsibility. It emphasizes the need for a conscientious and planned implementation of AI, ensuring both scientific integrity and ethical adherence in this dynamically evolving field.

Aspectos de la vida y obra del Dr. Bernardo Alberto Houssay / Aspects of the life and work of Dr. Bernardo Alberto Houssay

Con motivo del Día Mundial de la Ciencia y la Tecnología, se realizó en la Casa Museo Bernardo Houssay un conversatorio en el que expertos biógrafos resaltaron algunos aspectos de la trayectoria profesional del Premio Nobel de Medicina de 1947, destacando su actividad como investigador en fisiología y sus cualidades humanas. Estos importantes estudiosos del tema compartieron sus conocimientos en un selecto auditorio. (AU)

On the occasion of World Science and Technology Day, a discussion was held at the Bernardo Houssay House Museum in which expert biographers highlighted some aspects of the professional career of the 1947 Nobel Prize in Medicine, highlighting his activity as a researcher in physiology and his human qualities. These important scholars of the subject shared their knowledge in a select audience. (AU)

Práticas de enfermeiros na prevenção e rastreio do câncer de mama e de colo uterino / Practices performed by nurses in the prevention and screening of breast and cervical cancer / Prácticas de enfermería en la prevención y detección del cáncer de mama y cervicouterino

Objetivo: Identificar como ocorrem as práticas de prevenção e de rastreio do câncer de mama e de colo uterino realizadas por enfermeiros que atuam na Atenção Primária à Saúde do Rio Grande do Sul. Métodos: Trata-se de um estudo de abordagem qualitativa e de natureza analítica e compreensiva. Realizou-se entrevistas semiestruturadas. Os dados foram submetidos à análise de conteúdo do tipo temática proposta por Minayo. Os colaboradores foram 58 enfermeiros atuantes na Atenção Primária à Saúde. Resultados: Os resultados apontam que as práticas se desenvolvem em um contexto de crescente autonomia profissional e de protagonismo da Enfermagem. Aspectos como proximidade e vínculo com a comunidade, outros procedimentos e ações ofertadas nos atendimentos, incluindo a condução clínica/terapêutica, na vigência de sinais e sintomas de infecção, condizem com uma atenção mais ampla às necessidades de saúde e de cuidado às mulheres. Conclusão: O estudo evidencia a importância do respaldo de protocolos para a atuação segura das práticas dos enfermeiros da Atenção Básica, visando a prevenção e rastreio do câncer de mama e de colo uterino. Esses instrumentos devem ser de fácil acesso e constantemente atualizados a fim de garantir a padronização preconizada pelo Ministério da Saúde. (AU)

Objective: To identify how the breast and cervical cancer prevention and screening practices performed by nurses working in Primary Health Care in the state of Rio Grande do Sul occurs. Methods: This is a qualitative study with an analytical and comprehensive nature. The collaborators were 58 nurses working in Primary Health Care. Results: The results indicate that the practices are developed in a context of increasing professional autonomy and the role of Nursing. Aspects such as proximity and bonding with the community, other procedures and actions offered in the consultations, including clinical/therapeutic management in cases of signs and symptoms of infection, are consistent with a broader attention to women's health and care needs. Conclusion: The study highlights the importance of supporting protocols for the safe performance of Primary Care nurses' practices, aiming at the prevention and screening of breast and cervical cancer. These documents must be easily accessible and constantly updated in order to guarantee the standardization recommended by the Ministry of Health. (AU)

Objetivo: Identificar cómo las prácticas de prevención y detección del cáncer de mama y cervicouterino son realizadas por enfermeros que actúan en la Atención Primaria de Salud en Rio Grande do Sul. Métodos: Se trata de un estudio cualitativo de carácter analítico y comprensivo. Los colaboradores fueron 58 enfermeros que actuaban en la Atención Primaria de Salud. Resultados: Los resultados indican que las prácticas se desarrollan en un contexto de aumento de la autonomía profesional y del papel de la Enfermería. Aspectos como la proximidad y el vínculo con la comunidad, otros procedimientos y acciones que se ofrecen en las consultas, incluido el manejo clínico/terapéutico en casos de signos y síntomas de infección, son consistentes con una atención más amplia a las necesidades de salud y cuidado de las mujeres. Conclusión: El estudio destaca la importancia de protocolos para la actuación segura de las prácticas de los enfermeros de Atención Primaria, con el objetivo de la prevención y el tamizaje del cáncer de mama y de cuello uterino. Estos instrumentos deben ser de fácil acceso y constantemente actualizados para garantizar la estandarización recomendada por el Ministerio de Salud. (AU)

Latin American Forensic Odontology: A Scoping Review of its Current Research and the Objective/Subjective Nature of its Studies

SUMMARY: The new paradigm in Forensic Sciences initiated by the entry of genetics (the current standard of legal evidence) and accentuated by recognized wrongful convictions derived from experts today in the eye of criticism, has highlighted the potential for bias and error in forensic disciplines when they depend on human interpretation and subjectivity, which has not been avoided by Forensic Odontology (FO). However, a subjective judgment is not necessarily wrong, so the refinement of processes, the development of standards, and robust research can contribute to the validity of interpretation to increase objectivity. Latin America (LATAM) has its own realities and needs, which have conditioned the priorities and objectives of FO research. A scoping review is presented to systematically map the investigation of LATAM researchers and identify the objective or subjective nature of their assessments. LATAM shows interesting productivity and intentions to adhere to international standards, with Brazil leading this research significantly, followed by Chile and Colombia, among others. However, there is a disproportionate approach in certain lines of research (dental age estimation), and needs to address other quantitative studies, and to improve the visibility of the LATAM FO research.

El nuevo paradigma en ciencias forenses iniciado por la entrada de la genética (el actual estándar de la evidencia jurídica), y acentuado por reconocidas condenas injustas derivadas de pericias hoy en el ojo de la crítica, ha destacado el potencial de sesgo y error que poseen algunas disciplinas forenses cuando dependen de la interpretación humana y la subjetividad, lo cual no ha sido ajeno a la odontología forense (OF). Sin embargo, un juicio subjetivo no necesariamente es erróneo, con lo que el refinamiento de procesos, el desarrollo de estándares y la investigación robusta pueden contribuir a validar esa interpretación para aumentar su objetividad. Latinoamérica (LATAM) posee realidades y necesidades propias que han condicionado las prioridades y objetivos de la investigación en OF. Se presenta una revisión con búsqueda sistemática para mapear sistemáticamente la investigación en OF realizada por investigadores latinoamericanos, así como identificar la naturaleza objetiva o subjetiva de sus evaluaciones. LATAM demuestra una productividad interesante e intenciones de adherirse a estándares internacionales, con Brasil liderando significativamente esta investigación, seguido por Chile y Colombia entre otros. Sin embargo, se observa un enfoque desproporcionado en ciertas líneas de investigación (estimación de edad dental particularmente), y necesidad tanto de abordar otros estudios cuantitativos como de mejorar la visibilidad de la investigación latinoamericana en OF.

A ótica do enfermeiro sob a pesquisa em enfermagem na estratégia saúde da família, no município de Maceió/AL / The nurse's perspective on nursing research in the family health strategy, in the city of Maceió/AL

Analisar como a pesquisa é vivenciada pelos enfermeiros da Estratégia Saúde da Família. Método: pesquisa com abordagem qualitativa, descritiva e exploratória realizada junto aos enfermeiros do município de Maceió, Alagoas. Resultado: o município consta com 86 enfermeiros na Estratégia, sendo todos do sexo feminino. Desses, 10 foram submetidos a entrevista semiestruturada onde foi possível a elaboração de cinco categorias: a pesquisa e a vivência na Estratégia, a pesquisa e a economia, a pesquisa e a família, a pesquisa e à docência e a pesquisa e o crescimento profissional. Conclui-se que o enfermeiro precisa se apropriar da pesquisa científica e utilizá-la no seu campo de trabalho, principalmente na Saúde Pública, pois grande parte das pesquisas realizadas por estes profissionais ainda estão concentradas na docência, nos cursos de especializações, mestrados e doutorados.(AU)

To analyze how research is experienced by nurses in the Family Health Strategy. Method: research with a qualitative, descriptive and exploratory approach carried out with nurses from the city of Maceio, Alagoas. Result: the municipality has 86 nurses in the Strategy, all being female. Of these, 10 were subjected to a semi-structured interview where it was possible to create five categories: research and experience in Strategy, research and economics, research and family, research and teaching and research and professional growth. It is concluded that nurses need to take ownership of scientific research and use it in your field of work, mainly in Public Health, as much of the research carried out by these professionals is still concentrated in teaching in specialization, master's and doctoral courses.(AU)

Analizar cómo es vivida la investigación por enfermeros en la Estrategia Salud de la Familia. Método: investigación con enfoque cualitativo, descriptivo y exploratorio realizada con enfermeros de la ciudad de Maceió, Alagoas. Resultado: el municipio cuenta con 86 enfermeras en la Estrategia, todas mujeres. De ellos, 10 fueron sometidos a una entrevista semiestructurada donde fue posible crear cinco categorías: investigación y experiencia en Estrategia, investigación y economía, investigación y familia, investigación y docencia e investigación y crecimiento profesional. Se concluye que el enfermero necesita apropiarse de la investigación científica y utilizarla en su campo de trabajo, especialmente en Salud Pública, pues gran parte de la investigación realizada por estos profesionales aún se concentra en la docencia, cursos de especialización, maestrías y doctorados.(AU)

Acompañar una doble hospitalización en pandemia: la experiencia de padres con bebés hospitalizados mientras las madres se encuentran hospitalizadas por COVID-19 / Supporting a double hospitalization during the pandemic: The experience of fathers whose infants were hospitalized while their mothers were also hospitalized due to COVID-19

Introducción. La hospitalización de un hijo en la unidad de pacientes críticos neonatal puede ser altamente estresante para padres y madres, lo cual se intensificó en el contexto de la pandemia por COVID-19. A la fecha, no se han encontrado estudios que describan la experiencia de padres que vivieron la doble hospitalización simultánea de su pareja y de su hijo/a al nacer, durante la pandemia por COVID-19. Objetivos. Explorar la vivencia de los padres de tener a sus hijos/as hospitalizados en Neonatología mientras su pareja se encontraba hospitalizada por agravamiento de COVID-19. Población y método. Cuatro entrevistas semiestructuradas fueron realizadas y analizadas mediante un análisis interpretativo fenomenológico. Resultados. Se identificaron cuatro momentos cuando surgieron emociones específicas: a) inicio del contagio, b) hospitalización de la pareja, c) nacimiento del bebé y d) hospitalización del bebé. Culpa, miedo, angustia de muerte, soledad e incertidumbre aparecen muy tempranamente y luego se combinan con emociones como felicidad y empoderamiento, entre otras. La falta de contacto físico con sus parejas e hijos, y las fallas en la comunicación con los equipos de salud se destacan como factores que obstaculizan el ejercicio del rol paternal, mientras que una comunicación fluida con el equipo y una participación activa en los cuidados del bebé son factores protectores. Los padres cumplen una multiplicidad de roles, en la que prima el rol protector. Conclusiones. La comunicación y la atención centrada en la familia, y la participación activa en los cuidados de los bebés tienen el potencial de proteger contra el impacto de esta experiencia compleja de doble hospitalización.

Introduction. The hospitalization of a baby in the neonatal intensive care unit may be highly stressful for both mothers and fathers, and this was even more intense in the context of the COVID-19 pandemic.To date, no studies have been found that describe the experience of fathers who underwent the simultaneous hospitalization of their partner and newborn infant during the COVID-19 pandemic. Objectives. To explore the experience of fathers who had their babies hospitalized in the Neonatal Unit while their partner were hospitalized due to worsening of COVID-19. Population and method. Four semi-structured interviews were conducted and analyzed using an interpretative phenomenological analysis. Results. Four moments were identified when specific emotions arose: a) onset of infection, b) partner hospitalization, c) baby birth, and d) baby hospitalization. Guilt, fear, death anxiety, loneliness, and uncertainty appear very early and are later combined with emotions such as happiness and empowerment, among others. The lack of physical contact with their partners and babies and failures in communication with the health care team stand out as factors that hinder the exercise of the paternal role, while an effective communication with the health care team and active participation in the baby's care are protective factors. Fathers fulfill multiple roles, the most important of which is their role as protectors. Conclusions. Family-centered communication and care and active involvement in baby care may potentially protect against the impact of this complex experience of double hospitalization.

Pharmacological Effect of Phellodendri Chinensis Cortex and Active Components on Gout： A Review / 中国实验方剂学杂志

Gout is a metabolic disease closely associated with hyperuricemia and urate deposition. Because of the complex pathogenesis， high morbidity， multiple complications， and increasingly young patients， gout has received worldwide attention. Currently， western medicine mainly treats gout by lowering the uric acid level and reducing inflammation， which， however， causes serious adverse reactions and has contraindications. Phellodendri Chinensis Cortex （PCC） is the dried bark of Phellodendron chinense， with the effects of clearing heat， drying dampness， purging fire， detoxifying， and treating sores. Studies have shown that PCC and its active components have anti-inflammatory， pain-relieving， uric acid-lowering， and anti-gout activities， with extensive sources and high safety. PCC and its active components could prevent and treat gout through multi-targets and multi-pathways， whereas the systematic review remains to be carried out. Therefore， this paper summarized the pharmacological activities and mechanisms of PCC and its active components in the treatment of gout. The available studies have shown that PCC and its active components exert the anti-gout effect by lowering the uric acid level， reducing inflammation， alleviating oxidative stress， and regulationg intestinal flora， and protecting the kidneys. Particularly， the active components represented by alkaloids contribute obviously to the therapeutic effect of of PCC. Herein， we analyzed the problems and future development of the research on PCC， aiming to provide theoretical support and a scientific basis for the research and development of new drugs against gout.

Network Pharmacology in Research on Efficacy of Traditional Chinese Medicine and Compound Prescriptions / 中国实验方剂学杂志

The efficacy of traditional Chinese medicine （TCM） and compound prescriptions is confirmed based on practical experience. It is a highly generalized expression of the clinical characteristics and scope of prescriptions and a unique expression of the medical effects of TCM. Network pharmacology， as a cross-disciplinary field based on the theory of systems biology and multi-level analysis of biological systems， has become a common virtual screening tool in TCM research and gradually developed with the progress in big data and artificial intelligence. In the context of modern medicine， the efficacy of TCM compound prescriptions has a vague concept and lacks scientific evidence. Elucidating the connotation of TCM efficacy and guiding TCM theoretical research has become one of the hotspots and difficulties in TCM research. This article explores the feasibility of using network pharmacology for the research on the efficacy of TCM compound prescriptions and investigates whether the research results can represent part of the efficacy of prescriptions. Furthermore， the research platforms and algorithms in this field are summarized. The research ideas and existing problems in this field are proposed from the aspects of efficacy concept embodiment， target screening， result verification， efficacy network building， and homogenization avoiding of network pharmacology research results. Finally， the future development directions are prospected. This article is expected to provide a reference for exploring the modern biological basis of the efficacy of TCM and compound prescriptions and for the clinical application and theoretical research of TCM.

History and Clinical Application of Classic Famous Formula Danggui Sinitang / 中国实验方剂学杂志

Danggui Sinitang is first recorded in the Treatise on Cold Damage written by ZHANG Zhongjing in the Han dynasty. It is composed of Angelicae Sinensis Radix， Cinnamomi Ramulus， Paeoniae Radix Alba， Asari Radix et Rhizoma， Glycyrrhizae Radix et Rhizoma， Tetrapanacis Medulla， and Jujubae Fructus and serves as a classic formula for treating the syndrome of blood deficiency and cold reversal. This study systematically reviews the records of Danggui Sinitang in ancient Chinese medicine books of various dynasties and the modern clinical applications to probe into the composition， plant species， processing， dosage， decocting method， and indications of Danggui Sinitang， aiming to provide a reference for the development and clinical application of this classic formula. The review of the records showed that there were a variety of records of Danggui Sinitang with different composition， and the composition of this formula listed in the Treatise on Cold Damage has a significant impact on later generations and has been used by medical practitioners throughout history. Although the dosage of some drugs decreased during the Ming and Qing dynasties， the medical practitioners continued to use the original formula. In terms of processing， although there were slight changes in the processing of Angelicae Sinensis Radix， Paeoniae Radix Alba， Glycyrrhizae Radix et Rhizoma， and Tetrapanacis Medulla， the original processing method was inherited. In terms of indications， Danggui Sinitang was designed to treat cold reversal due to blood deficiency and dysentery. Furthermore， it was used to treat headache， convulsive disease， infantile convulsion， and private part adduction in the Ming and Qing dynasties. Nowadays， this formula is mostly used to treat diabetes peripheral neuropathy， rheumatoid arthritis， dysmenorrhea， Raynaud's disease and other diseases. In terms of precautions， ancient physicians believed that Danggui Sinitang should not be taken by pregnant women and should only be used for limb chills caused by blood deficiency and cold coagulation. For limb chills caused by other reasons， this formula should not be used indiscriminately. Modern research has not reported any serious adverse reactions related to this formula. Danggui Sinitang has a definite therapeutic effect. In subsequent research and development， quality control standards of Danggui Sinitang should be established while its safety is ensured， and the related preparations should be developed and applied.

Perspective of Calcium Imaging Technology Applied to Acupuncture Research / 中国结合医学杂志

Acupuncture, a therapeutic treatment defined as the insertion of needles into the body at specific points (ie, acupoints), has growing in popularity world-wide to treat various diseases effectively, especially acute and chronic pain. In parallel, interest in the physiological mechanisms underlying acupuncture analgesia, particularly the neural mechanisms have been increasing. Over the past decades, our understanding of how the central nervous system and peripheral nervous system process signals induced by acupuncture has developed rapidly by using electrophysiological methods. However, with the development of neuroscience, electrophysiology is being challenged by calcium imaging in view field, neuron population and visualization in vivo. Owing to the outstanding spatial resolution, the novel imaging approaches provide opportunities to enrich our knowledge about the neurophysiological mechanisms of acupuncture analgesia at subcellular, cellular, and circuit levels in combination with new labeling, genetic and circuit tracing techniques. Therefore, this review will introduce the principle and the method of calcium imaging applied to acupuncture research. We will also review the current findings in pain research using calcium imaging from in vitro to in vivo experiments and discuss the potential methodological considerations in studying acupuncture analgesia.

Research progress of ferroptosis in ocular fundus diseases / 国际眼科杂志(Guoji Yanke Zazhi)

Ferroptosis is a unique and new mode of cell death, which is driven by iron-dependent lipid peroxidation and mainly characterized by the accumulation of reactive oxygen species in cytoplasm and lipids. Ferroptosis plays an important role in the pathogenesis of many ocular fundus diseases, such as retinitis pigmentosa, age-related macular degeneration, diabetic retinopathy, retinal detachment, retinoblastoma and so on. The use of ferroptosis-related inhibitors or activators can regulate the course of the disease and provide new ideas for the research, prevention and treatment of ophthalmic diseases.

Healthcare big data based visual analysis of research hotspots and trends on global uveitis / 国际眼科杂志(Guoji Yanke Zazhi)

AIM: To explore the current status, research hotspots, and trends of global uveitis research to provide a theoretical basis and references for researchers in the field of uveitis, and promote further development in this area.METHODS: Relevant literatures on uveitis were retrieved from the China National Knowledge Infrastructure(CNKI)database, Wanfang database, and Web of Science core collection database since their establishment until 24 August 2023. The country/publishing institutions, research authors, high-frequency keywords, and burst keywords were visual analyzed by using software such as GraphPad Prism 9, CiteSpace 6.2. R2, and VOSviewer.RESULTS: Research teams for uveitis have been formed in various countries globally. The top three countries in terms of publications are the United States of America(7 585 papers), the United Kingdom(2 412 papers)and Germany(1 679 papers). The top three foreign institutions in terms of publications are Harvard University, Oregon Health & Science University, and Moorfields Eye Hospital, while the top three domestic institutions are Affiliated Eye Hospital of Shandong University of Traditional Chinese Medicine, Chongqing Medical University, and Zhongshan Ophthalmic Center, Sun Yat-sen University. The analysis of high-frequency keywords and burst keywords in Chinese and English shows that research hotspots mainly focus on exploring pathogenesis and different treatment methods for uveitis. The research hotspots related to uveitis treatment are transitioning to molecular biology-related research topics, such as molecular biological signaling pathways(NF-κB signaling pathway with a strength value of 22.89), biological agents(adalimumab with a strength value of 32.21), and tumor necrosis factor(with a strength value of 48.44). Related research is also expanding to basic experiments on relevant rats.CONCLUSIONS: In recent years, the research hotspots and trends of global uveitis mainly focus on precise diagnosis, pathogenesis, and more effective treatment methods. It is important for more scholars to dedicate themselves to uveitis-related research in the future to make breakthroughs and progress in the field. More large-scale and multicenter clinical studies on uveitis can provide high-quality research evidence.

Mechanism of Aurantii Fructus and Its Active Components in Regulating Gastrointestinal Motility： A Review / 中国实验方剂学杂志

Gastrointestinal motility disorder is an important cause of digestive system diseases. Patients often suffer from nausea， vomiting， gastric retention， gastroparesis， constipation， and many other symptoms， and their quality of life is seriously reduced. Prokinetic agents are routinely used in clinical practice， but their long-term use is prone to problems such as reduced efficacy and increased adverse reactions. Since the incidence of gastrointestinal diseases has continued to rise globally in recent years， there is an urgent need for clinical development of safe and effective treatment strategies. Aurantii Fructus， a traditional Chinese medicine， has the effect of smoothing Qi and eliminating distention， and it has been used to treat gastrointestinal diseases for thousands of years. In modern clinical practice， it is mainly used for the treatment and auxiliary treatment of various gastrointestinal diseases such as functional dyspepsia， functional constipation， and irritable bowel syndrome. The efficacy is remarkable， and no adverse reactions have been reported at conventional doses. Therefore， it can greatly improve the symptoms of patients with gastrointestinal diseases and improve their quality of life. Modern research has revealed that there are many active components in Aurantii Fructus， among which flavonoids have the highest content and the most types. Flavonoids are the main active components in Aurantii Fructus to regulate gastrointestinal motility. Aurantii Fructus and its active components can affect gastrointestinal hormones， neural pathways， Cajal mesenchymal cells， and other multiple mechanisms. They can adjust gastrointestinal motility and correct gastrointestinal motility disorders， showing potential application value in the treatment of gastrointestinal motility disorders. However， a comprehensive analysis of Aurantii Fructus in this aspect is still lacking. This study summarized the pharmacological activities of active components of Aurantii Fructus extract and its flavonoids， volatile oils， alkaloids， and coumarin on the regulation of gastrointestinal motility and explored the latest research progress on its mechanism. Finally， the adverse reactions of Aurantii Fructus were summarized. It aims to provide a scientific basis for the research and clinical application of Aurantii Fructus and its active components in the regulation of gastrointestinal motility.

Anti-cancer Effect and Mechanism of Chinese Herbal Medicine Saponins： A Review / 中国实验方剂学杂志

Cancer， one of the deadliest diseases caused by cells escaping homeostasis， abnormal proliferation， and abnormal differentiation， is fast becoming one of the most burdensome diseases of this century. With decades of human research and cognitive changes in cancer， cancer treatment is also developing rapidly， but there is still a lack of effective treatment and countermeasures. Especially， the search for safe， efficient， and non-toxic drugs has become a long-term goal in the field of cancer. Saponins extracted and separated from traditional Chinese medicine can improve cancer through various pathways and have almost no toxic side effects. Therefore， the research on the anti-cancer effect of saponins is heating up. It is found that saponins play anti-tumor roles by inhibiting proliferation， metastasis， and angiogenesis of cancer cells， promoting apoptosis of cancer cells， inducing autophagy of tumor cells， and regulating miRNA expression and immune functions. Chinese herbal medicine saponins can regulate secretory glycoprotein /β-catenin （Wnt/β-catenin）， adenylate activated protein kinase （AMPK）， nuclear transcription factor-κB （NF-κB）， mitogen-activated protein kinase （MAPK）， phosphatidylinositol 3-kinase （PI3K）/protein kinase B （Akt）/mammalian target of rapamycin （mTOR）， Janus kinase/activator of signal transduction and transcription 3 （JAK/ STAT3）， hypoxia-inducible factor-1α （HIF-1α）， Toll-like receptor （TLR）， and other related signaling pathways to get involved in the proliferation， metastasis， angiogenesis， apoptosis， autophagy， and other processes of cancer cells， thus interfering with the progression of cancer. Therefore， the focus of this review is to update the discovery and evaluation of Chinese herbal medicine saponins with anti-cancer properties， clarify their mechanism of action， including the progress of related signaling pathways， and deepen the understanding of the anti-cancer function of Chinese herbal medicine saponins， so as to provide a new perspective and direction for the prevention and treatment of tumors by traditional Chinese medicine and better promote the development and utilization of resources.

Traditional Chinese Medicine in Treatment of Parkinson's Disease by Regulating TLR4/NF-κB Signaling Pathway： A Review / 中国实验方剂学杂志

Parkinson's disease （PD） is a common neurological degenerative disease in the middle-aged and elderly， characterized by pathological changes of progressive degeneration of dopaminergic neurons in the substantia nigra and Lewy body formation， with high prevalence and long course of disease. The drug is mainly used to treat PD in western medicine， and the early curative effect is remarkable. However， with the progression of the disease and the long-term use of the drug， the efficacy will be significantly reduced， or there may be sports complications， and the long-term efficacy is not good. As a traditional medical system， traditional Chinese medicine has a unique understanding of PD. Traditional Chinese medicine plays an important role in the treatment of PD， which is natural， mild， safe， and effective， and it can cooperate with western medicine to enhance its efficacy and reduce the adverse reactions of western medicine. The pathogenesis of PD is complex， involving multiple levels such as mitochondrial dysfunction and apoptosis. Neuroinflammation is also involved in the progressive degeneration of dopaminergic neurons in PD. The Toll-like receptor 4 （TLR4）/nuclear factor-κB （NF-κB） signaling pathway is a classic inflammatory pathway， and its expression changes play an important role in the occurrence and development of inflammatory response in the body. In recent years， the research on this pathway in TCM is increasing. This paper summarized the literature of traditional Chinese and western medicine in the past 10 years and reviewed the relevant mechanism of TCM regulation of TLR4/NF-κB pathway in the treatment of PD from the aspects of TCM monomer， compound， and other TCM therapies， so as to provide some references for the search for new targets of drug therapy and gene therapy and the in-depth study of TCM prevention and treatment of PD.