ABSTRACT
We report a unique case of a 4-year-old girl with an intriguing fibrohistiocytic tumour. Magnetic resonance imaging scans showed a dural mass of variegated intensity compressing the left occipital pole and apparently extending toward the superior sagittal sinus. Grossly, the cut surface of the surgical specimen was yellow, pale, and soft with reddish kernel-like crusts. Histologically, the yellow areas resembled cholesterol granulomas with widespread coagulative necrosis, cholesterol clefts, powdery calcification, foreign body-type giant cells, and foamy macrophages, while the scattered red spots contained numerous multinucleated giant cells of foreign-body and Touton types, the former with amphophilic to slightly eosinophilic cytoplasm. Immunoperoxidase reactions confirmed the expression of histiocytic markers and vimentin. As far as we know, no tumour displaying these peculiar morphological features has yet been described.
Subject(s)
Child, Preschool , Female , Humans , Cholesterol , Cytoplasm , Eosinophils , Giant Cells , Giant Cells, Foreign-Body , Granuloma , Macrophages , Magnetic Resonance Imaging , Necrosis , Superior Sagittal Sinus , VimentinABSTRACT
Reticulohistiocytoma is a rare, benign histiocytic proliferation of the skin or soft tissue. A 5-month-old healthy girl visited our clinic for an enlarging nodule on the center of her right palm. The clinical differential diagnosis included xanthogranuloma and primary cutaneous CD4 positive small/medium T-cell lymphoma. Histopathology of the nodule showed abundant eosinophilic and glassy cytoplasm. The nuclei were round to oval shaped, with focal irregular nuclear membrane, and mitotic figures were absent. Immunohistochemical study determined that the cells were positive for CD68 but negative for CD1a. She was finally diagnosed with reticulohistiocytoma (solitary epithelioid histiocytoma).
Subject(s)
Female , Humans , Infant , Cytoplasm , Diagnosis, Differential , Eosinophils , Histiocytosis, Non-Langerhans-Cell , Lymphoma, T-Cell , Nuclear Envelope , SkinABSTRACT
Reticulohistiocytoma is a rare, benign histiocytic proliferation of the skin or soft tissue. A 5-month-old healthy girl visited our clinic for an enlarging nodule on the center of her right palm. The clinical differential diagnosis included xanthogranuloma and primary cutaneous CD4 positive small/medium T-cell lymphoma. Histopathology of the nodule showed abundant eosinophilic and glassy cytoplasm. The nuclei were round to oval shaped, with focal irregular nuclear membrane, and mitotic figures were absent. Immunohistochemical study determined that the cells were positive for CD68 but negative for CD1a. She was finally diagnosed with reticulohistiocytoma (solitary epithelioid histiocytoma).
Subject(s)
Female , Humans , Infant , Cytoplasm , Diagnosis, Differential , Eosinophils , Histiocytosis, Non-Langerhans-Cell , Lymphoma, T-Cell , Nuclear Envelope , SkinABSTRACT
Reticulohistiocytosis represents a rare spectrum of non-Langerhans cell histiocytosis: the solitary cutaneous form (reticulohistiocytoma), the diffuse cutaneous form without systemic involvement, and multicentric reticulohistiocytosis with systemic involvement. We report a case of solitary cutaneous reticulohistiocytosis in a 46-years-old male, who presented with an asymptomatic firm, dome-shaped nodule on the right vestibule of nose. The lesion was completely excised and no evidence of recurrence was observed.
Subject(s)
Humans , Male , Histiocytosis, Non-Langerhans-Cell , Nose , RecurrenceABSTRACT
A 21 year old Filipino male presented with swelling of the second right hand digit unresponsive to antibiotics. Amputation revealed chronic inflammation and negative cultures. He developed sterile conjunctivitis and a generalized eruption of asymptomatic red papules and nodules. First skin biopsy revealed a diffuse infiltrate of epithelioid and foamy histiocytes, diagnosed as "juvenile xanthogranuloma." The second biopsy revealed large histiocytes with a "ground-glass" eosinophilic cytoplasm, multinucleated giant cells, and mixed cell infiltrate. Immunohistochemistry showed histiocytes staining with (+)S100 and (+)CD68, and (-)CD1a. Final diagnosis was "multicentric reticulohistocytosis." Despite treatment with oral prednisone, methotrexate and alendronate, lesions were progressive. CONCLUSION: This fascinating case manifests with overlapping features of both juvenile xanthogranuloma and multicentric reticulohistiocytosis, and lead the authors to suggest considering the spectrum of diseases called the non-Langerhans cells histiocytosis when presented with a generalized nodular eruption.
Subject(s)
Humans , Male , Young Adult , Antigens, CD1 , Biopsy , Conjunctivitis , Exanthema , Giant Cells , Histiocytes , Histiocytosis, Non-Langerhans-Cell , Inflammation , MethotrexateABSTRACT
Reticulohistiocytosis represents a rare spectrum of non-Langerhans cell histiocytosis: the solitary cutaneous form (reticulohistiocytoma), the diffuse or multiple cutaneous form without systemic involvement, and multicentric reticulohistiocytosis with systemic involvement. To the best of our knowledge, there have been relatively few reports in the literature of solitary cutaneous reticulohistiocytoma found on the lip. We report here on a case of solitary cutaneous reticulohistiocytoma in a 58-year-old male, who presented with an asymptomatic dome-shaped nodule adjacent to the upper lip. The histopathologic examination revealed a dense dermal infiltrate, that was composed predominantly of large oncocytic histiocytes and multinucleated giant cells with abundant granular eosinophilic cytoplasms, which had a "ground-glass" appearance.
Subject(s)
Humans , Male , Middle Aged , Cytoplasm , Eosinophils , Giant Cells , Histiocytes , Histiocytosis , Histiocytosis, Non-Langerhans-Cell , LipABSTRACT
Solitary cutaneous reticulohistiocytoma is characterized by a solitary reddish nodule or papule confined to the skin without evidence of arthritis or underlying systemic illness. We report a case of solitary cutaneous reticulohistiocytoma in a 41-year-old female, who presented with an asymptomatic, firm, dome-shaped nodule on the tragus of left ear. Histopathologically, numerous multinucleated giant cells with a ground glass appearance was shown in the dermis. Immunohistochemical stains of CD68 was positive. The lesion was completely excised and no evidence of recurrence was observed.
Subject(s)
Adult , Female , Humans , Arthritis , Coloring Agents , Dermis , Ear , Giant Cells , Glass , Histiocytosis, Non-Langerhans-Cell , Recurrence , SkinABSTRACT
Multiple cutaneous reticulohistiocytoma, a unique pattern in the spectrum of the reticulohistiocytoses, is a rare reactive granulomatous condition. We report a case of multiple cutaneous reticulohistiocytoma in a 36-year-old female, who showed multiple, pruritic, yellow-reddish brown papules on her posterior neck and right upper back for 1 year. Histologically, numerous multinucleated giant cells with a ground glass appearance observed in the dermis. Immunohistochemical stains of CD68, Vimetin were positive. The lesions were subsided after applying topical steroid for 1 month.
Subject(s)
Adult , Female , Humans , Coloring Agents , Dermis , Giant Cells , Glass , Histiocytosis, Non-Langerhans-Cell , NeckABSTRACT
Reticulohistiocytoma, a rare form of non-Langerhans cell histiocytoses, usually presents it-self as a single cutaneous nodule mainly on the head and neck of young men without associated arthritis. We describe an 18-year-old male patient with a red dome-shaped nodule of 2 months' duration on the scalp. Histologic examination of the excised mass revealed numerous large, mononucleated or multinucleated histiocytes with abundant eosinophilic, finely granular cytoplasm having a ground-glass appearance. Immunohistochemical staining was positive for vimentin, lysozyme, and factor XIIIa, supporting a dermal dendrocyte lineage. Ultrastructurally, large mononuclear or multinucleated cells exhibiting numerous peripheral villi contained pleomorphic cytoplasmic inclusions, fatty droplets and dense bodies. Our clinicopathologic findings support the concept that reticulohistiocytoma is a variant of adult xanthogranuloma.
Subject(s)
Adolescent , Adult , Humans , Male , Arthritis , Cytoplasm , Eosinophils , Factor XIIIa , Head , Histiocytes , Histiocytosis , Histiocytosis, Non-Langerhans-Cell , Inclusion Bodies , Muramidase , Neck , Scalp , VimentinABSTRACT
Solitary cutaneous reticulohistiocytoma is a type of reticulohistiocytosis. The cytoplasm of tumo cells characteristically shows abundant eosinophilic "ground-glass" appearance. We report a case of this rare cutaneous tumor in a 54-year-old woman. It was present as a single nodule on the right index finger of the patient for seven years.