ABSTRACT
Retinopathy of premature is characterized by retinal vascular dysplasia,angiogenesis,fiber proliferation and retinal detachment,which can lead to a variety of serious complications,including permanent blindness.Angiopoietin-1,which has a close relationship with the incidence of ROP,is an important factor affecting angiogenesis.This paper will discuss the relations between angiopoietin-1 and retinopathy of premature.
ABSTRACT
OBJECTIVE: To determine whether magnesium sulfate exposure is associated with a reduced risk of perinatal complications in extremely low birth weight infants (ELBWIs). METHODS: Total 351 inborn extremely low birth weight infants admitted between January 2000 and December 2008 to Samsung Medical Center were divided into the prenatal MgSO4-exposed group (n=76), and control group (n=275), and were retrospectively analyzed. Multiple demographic, clinical characteristics and neonatal complications were compared. RESULTS: Prenatally MgSO4-exposed ELBWIs had significantly higher gestational age, birth weight, and incidence of small for gestational age. In neonatal complications, retinopathy of premature (ROP) treated with laser was less common in MgSO4-exposed group. There were no differences between two groups in the incidence of respiratory distress syndrome (RDS), bronchopulmonary dysplasia (BPD), patent ductus arteriosus (PDA), PDA ligation, intraventricular hemorrhage (IVH), periventricular leukomalacia (PVL), necrotizing enterocolitis (NEC), and mortality. CONCLUSION: Perinatal exposure to magnesium sulfate was associated with decreased incidence of ROP treated with laser.