Mechanical Properties of Teeth Restored After Selective Caries Excavation. Systematic Review and Meta-Analysis

ABSTRACT: The aim of this study was to systematically review the literature of in vitro studies comparing the mechanical properties of teeth restored after selective caries excavation (SCE) and complete caries excavation (CCE). The PubMed/MEDLINE and EMBASE electronic databases were searched systematically. In vitro studies investigating the mechanical properties of teeth restored after SCE, were independently checked by two authors. Inclusion criteria were: (1) performing SCE (2) mentioning the teeth were later restored, and (3) evaluating mechanical properties of the restored teeth. Meta-analysis was performed with and without discriminating between shallow and deep lesions. From 1,859 potentially eligible studies, 14 were selected for full text analysis and 5 were included in the meta- analysis. Fracture resistance was significantly lower after SCE than after CCE in overall analysis (SMD[95%CI]=-1.62[-3.04,-0.20]) and for deep lesion (SMD[95%CI]=-1.62[-2.62,-0.61]), whereas cuspal deflection at 200 and 400N was significantly higher after SCE than after CCE for discriminated and non- discriminated analyses. Furthermore, for shallow lesions the risk of catastrophic fracture was significantly lower after SCE than CCE (RR[95%CI]=0.58[0.43,0.78]). The included studies presented low and medium risk of bias. The mechanical behavior of restored teeth seems to be affected by the excavation strategy. Although there is a tendency for lower fracture resistance and higher cuspal deflection after SCE, there is a lower risk of catastrophic failure when compared to CCE. However, this conclusion is based on very few in vitro studies.

RESUMEN: El objetivo de este estudio fue revisar sistemáticamente la literatura de estudios in vitro que comparan las propiedades mecánicas de los dientes restaurados después de la excavación selectiva de caries (ESC) y la excavación de caries completa (ECC). Se realizaron búsquedas sistemáticas en las bases de datos electrónicas PubMed / MEDLINE y EMBASE. Los estudios in vitro que investigan las propiedades mecánicas de los dientes restaurados después de la ESC fueron verificados de forma independiente por dos autores. Los criterios de inclusión fueron: (1) realizar ESC (2) mencionar que los dientes fueron posteriormente restaurados y (3) evaluar las propiedades mecánicas de los dientes restaurados. El metanálisis se realizó con y sin discriminación entre lesiones superficiales y profundas. De 1.859 estudios potencialmente elegibles, se seleccionaron 14 para el análisis de texto completo y 5 se incluyeron en el metanálisis. La resistencia a la fractura fue significativamente menor después de ESC que después de CCE en el análisis general (DME [IC del 95 %] = - 1,62 [-3,04, -0,20]) y para la lesión profunda (DME [IC del 95 %] = - 1,62 [-2,62, - 0,61]), mientras que la deflexión de las cúspides a 200 y 400 N fue significativamente mayor después de ESC que después de CCE para análisis discriminados y no discriminados. Además, para las lesiones superficiales, el riesgo de fractura catastrófica fue significativamente menor después de ESC que de CCE (RR [IC 95 %] = 0,58 [0,43,0,78]). Los estudios incluidos presentaron riesgo de sesgo bajo y medio. El comportamiento mecánico de los dientes restaurados parece verse afectado por la estrategia de excavación. Aunque existe una tendencia a una menor resistencia a la fractura y una mayor deflexión de la cúspide después de la ESC, existe un menor riesgo de falla catastrófica en comparación con la CCE. Sin embargo, esta conclusión se basa en muy pocos estudios in vitro.

Effects of exercise on polycystic ovary syndrome in obese patients / 中国基层医药

Polycystic ovary syndrome (PCOS) is a common endocrine disease in gynecology. PCOS has complex etiology and diverse clinical manifestations and greatly affects women's physical and mental health. Obesity, insulin resistance and hyperandrogenemia are closely related and interact with each other, which are the main pathophysiological characteristics of PCOS. Exercise, as an important lifestyle intervention, plays a positive role in PCOS patients. This paper reviews the effects of exercise on endocrine, metabolism, reproduction, cardiopulmonary function, emotion, and quality of life in obese patients with PCOS, so as to provide reference for exercise therapy of in the future

Research progress of aspartyl-(asparaginyl) β-hydroxylase in hepatocellular carcinoma / 中华肝胆外科杂志

Hepatocellular carcinoma is characterized by a high rate of incidence,along with significant likelihood of postoperative recurrence and metastatic,whereas its underlying mechanism remains considerably unclear.The overexpression of Aspartyl/Asparaginyl beta-hydroxylase (ASPH,AAH) was initially found in hepatocellular carcinoma and cholangiocarcinoma,signifying its involving in multiple biological behaviors of hepatocellular carcinoma.Here we review recent advances on ASPH in hepatocellular carcinoma,aiming to provide a new theoretical basis for its treatment prospectively.

Research progress in the anti-cancer effect of metformin / 天津医药

The incidence of malignancy tumors has increased significantly recent years in patients with type 2 diabetes mellitus (T2DM).As the first-line oral medicine of T2DM,in addition to the safe and effective hypoglycemic effect,metformin can reduce the incidence and mortality of cancer,and improve the prognosis in T2DM patients.While the exactly anti-tumor mechanisms of mefformin is not yet clear,which might be the inhibition of proliferation and promotion of apoptosis of tumor cells mainly by acting on an adenosine monophosphate activated protein kinase (AMPK) and microRNAs (miRNAs).And metformin can inhibit migration and invasion of tumor cells,as well as strengthen the effects of chemotherapy drugs.This article reviews the recent research progress of clinical and epidemiological studies and anticancer mechanisms of metformin.