ABSTRACT
Objective To investigate the expression of RhoC mRNA in the gastric carcinoma (GC) and paracarcinoma gastric mucosa tissues (PGMT) and their relationship with clinical pathological features.Methods RhoC mRNA was examined by semi-quantitative reverse transcription polymerase chain reaction (RT-PCR) in 23 cases of primary gastric carcinoma and the paracarcinoma gastric mucosa tissues.Results The opacity density of RhoC mRNA in 23 cases of GC was 1.40±0.23,higher than that of PGMT (0.36±0.15)(P<0.01).In addition.RhoC mRNA in gastric carcinoma tissues were positively related to invasion depth,TNM stage and lymph node metastasis (P<0.01),Conclusion The overexpression of RhoC mRNA in GC may be closely related to the carcinogenesis,development,invasion and metastasis of gastric carcinoma,which is a frefered biomarker for early diagnosis.