Polymorphism of black snake venom Ribonuclease II –chromatographical forms

By ion-exchange chromatography, the existance of Ribonuclease from Vietnam’s black cobra. Venum in multiple molecular forms was confirmed. Its two separated peaks were noted on CM-cellulose column chromatography. At present , the nature of these RNase chromatographic forms are unknown, but it is probably that they possess quaternary structure