Quantitative analysis of risk assessment indicators for re-introduction of imported malaria in China / 中国血吸虫病防治杂志

Objective To quantitatively analyze the risk indicators of re-introduction of imported malaria in China and their weighting coefficients, so as to investigate the difference in the contribution of risk indicators included in the current risk assessment framework for re-introduction of imported malaria in China to the risk assessment of re-introduction of imported malaria. Methods Publications pertaining to the risk assessment framework for re-introduction of imported malaria in China that reported the risk indicators and their weighting coefficients were retrieved in PubMed, Web of Science, CNKI, Wanfang Data, and VIP with terms of “malaria”, “re-introduction/re-transmission/re-establishment”, “risk assessment/risk evaluation/risk prediction” from the inception of the database through 3 August 2023, and literature search was performed in Google Scholar to ensure the comprehensiveness of the retrieval. Basic characteristics of included studies were extracted using pre-designed information extraction forms by two investigators, and data pertaining to risk indicators of re-introduction of imported malaria were cross-checked by these two investigators. The risk indicators included in the risk assessment framework for re-introduction of imported malaria in China and their weighting coefficients were visualized with the Nightingale’s rose diagrams using the software R 4.2.1, and the importance of risk indictors was evaluated with the frequency of risk indicators included in the risk assessment framework and the ranking of weighting coefficients of risk indicators. In addition, the capability of risk indicators screened by different weighting methods was compared by calculating the ratio of the maximum to the minimum of the weighting coefficients of the risk indicators screened by different weighting methods. Results A total of 2 138 publications were retrieved, and following removal of duplications and screening, a total of 8 publications were included in the final analysis. In these 8 studies, 8 risk assessment frameworks for re-introduction of imported malaria in China and 52 risk indicators of re-introduction of imported malaria were reported, in which number of imported malaria cases (n = 8) and species of malaria vectors were more frequently included in the risk assessment frameworks (n = 8), followed by species of imported malaria parasites (n = 6) and population density of local malaria vectors (n = 6), and species of local malaria vectors (n = 6), number of imported malaria cases (n = 5) and species of imported malaria parasites had the three highest weighting coefficients (n = 4). The weighting methods included expert scoring method, combination of expert scoring method and analytic hierarchy process, and combination of expert scoring method and entropy weight method in these 8 studies, and the ratios of the maximum to the minimum of the weighting coefficients of the risk indicators screened by the expert scoring method were 1.143 to 2.241, while the ratios of the maximum to the minimum of the weighting coefficients of the risk indicators screened by combination of the expert scoring method and analytic hierarchy process were 34.970 to 162.000. Conclusions Number of imported malaria cases, species of imported malaria parasites, species of local malaria vectors and population density of local malaria vectors are core indicators in the current risk assessment framework for re-introduction of imported malaria in China. Combination of the expert scoring method and analytic hierarchy process is superior to the expert scoring method alone for weighting the risk indicators.

Congenital syphilis associated with hearing screening failure in southern Brazilian newborns

Abstract Objective: To estimate the association between congenital syphilis and neonatal hearing screening failure in the state of Santa Catarina between 2017 and 2019. Methods: This is a cross-sectional, retrospective, analytical study with secondary data of neonates from the state of Santa Catarina born between January 2017 and December 2019. We used logistic regression analysis to estimate the association between the main exposure (congenital syphilis) and the study outcome (failure in the Neonatal Hearing Screening). Results: The study included 21,434 newborns evaluated in a Brazilian hearing health care service. A total of 351 (1.6%) newborns failed the Neonatal Hearing Screening, and 364 (1.7%) had congenital syphilis. In the adjusted analysis, newborns with congenital syphilis were 3.25 times as likely to fail the Neonatal Hearing Screening as neonates without this disease (95% CI: 2.01; 5.26). As for maternal age, the sample had a higher prevalence (53.5%) of mothers aged 20-29 years. Conclusion: There was an association between congenital syphilis and failure in Universal Neonatal Hearing Screening in the sample studied. There is a need for investments in public policies to value and strengthen the hearing screening program in the state to provide early diagnosis and intervention. Level of evidence: 5

Asociación del índice triglicérido-glucosa con colesterol-no-HDL aumentado como indicador de riesgo cardiometabólico en estudios poblacionales / Association of the triglyceride-glucose index with increased non-HDL-cholesterol as an indicator of cardiometabolic risk in population studies / Associação do índice triglicerídeo-glicose com colesterol-não-HDL aumentado como indicador de risco cardiometabólico em estudos populacionais / Reconocimiento a la trayectoria del Prof. Dr. Juan Miguel Castagnino†

Resumen Se propone la asociación de dos indicadores para la detección de personas con riesgo cardiometabólico (RCM) en estudios poblacionales: triglicéridoglucosa (TyG) >8,75 y colesterol-no-HDL (C-no-HDL) ≥160 mg/dL, que se denominará indicador de RCM. La enfermedad cardiovascular aterosclerótica (ECVA) y la diabetes tipo 2 (DT2) son muy frecuentes. TyG aumentado es un estimador de insulinorresistencia y síndrome metabólico (SM) y está relacionado con la detección precoz de riesgo para DT2. C-no-HDL ≥160 mg/ dL ha sido recomendado informarlo en los estudios de laboratorio vinculados con el riesgo para ECVA, sus aumentos están relacionados con todas las lipoproteínas aterogénicas y es de mucho interés en hipertrigliceridemias y SM, por la presencia de lipoproteínas remanentes. En un estudio poblacional sobre 540 personas del sur argentino se halló un aumento significativo de RCM luego de los 20 años y luego de los 40 años de edad un tercio de la población lo tenía presente. El RCM se halló asociado con el índice de masa corporal (IMC), luego de ajustar para edad y género. Después de los 30 años, el RCM estaba presente en un tercio de las personas con IMC ≥27 kg/m2. En otro estudio realizado en personas con riesgo para DT2 con RCM presente, 65,8% tenían HOMA-IR (homeostasis model assessment-insulin-resistance) >2,1 y 61,8% SM. Se concluye que la asociación de TyG >8,75 y C-no-HDL ≥160 mg/dL (RCM) podría ser de interés para la detección de grupos poblacionales con alto riesgo cardiometabólico, en la prevención de ECVA y DT2.

Abstract The association of two indicators was proposed for the detection of people with cardiometabolic risk (CMR) in population studies: triglyceride-glucose (TyG) >8.75 and non-HDL-cholesterol (Non-HDL-C) ≥160 mg/dL, which will be called CMR indicator. Atherosclerotic cardiovascular disease (ACVD) and type 2 diabetes (T2D) are very common. Increased TyG is an estimator of insulin resistance and metabolic syndrome (MS) and is related to the early detection of risk for T2D. Non-HDL-C≥160 mg/dL has been recommended to be reported in laboratory studies related to the risk for CVA and its increases are related to all atherogenic lipoproteins and it is of great interest in hypertriglyceridemia and MS, due to the presence of lipoproteins remnants. In a population study of 540 people from Southern Argentina, a significant increase in CMR was found after 20 years of age, and after 40 years of age; a third of the population had it. CMR was found to be associated with body mass index (BMI), after adjusting for age and gender. After age 30 years, CMR was present in a third of the people with a BMI ≥27 kg/m2. In another study conducted in people at risk for T2D with CMR present, 65.8% had HOMA-IR (homeostasis model assessment-insulin-resistance) >2.1 and 61.8% MS. It is concluded that the association of TyG <8.75 and non-HDL-C ≥160 mg/dL (CMR) could be of interest for the detection of population groups with high cardiometabolic risk, in the prevention of ACVD and T2D.

Resumo A associação de dois índices é proposta para a detecção de pessoas com risco cardiometabólico (RCM) em estudos populacionais: triglicerídeo-glicose (TyG) >8,75 e colesterol-não-HDL (C-não-HDL) ≥160 mg/ dL, que será denominado indicador de RCM. A doença cardiovascular aterosclerótica (DCVA) e o diabetes tipo 2 (DT2) são muito comuns. TyG aumentado é um estimador de resistência à insulina e síndrome metabólica (SM) e está relacionado com a detecção precoce de risco para DT2. C-não-HDL ≥160 mg/dL tem sido recomendado para relatá-lo em estudos laboratoriais vinculados com o risco de DCVA e seus aumentos estão relacionados com todas as lipoproteínas aterogênicas e é de grande interesse na hipertrigliceridemia e SM devido à presença de restos de lipoproteínas. Em um estudo populacional de 540 pessoas do sul da Argentina, foi encontrado um aumento significativo de RCM após os 20 anos de idade e, depois dos 40 anos, um terço da população o apresentava. A RCM foi associada ao índice de massa corporal (IMC), após ajustar para idade e gênero. Após os 30 anos, a RCM estava presente em um terço das pessoas com IMC ≥27 kg/m2. Em outro estudo realizado em pessoas com risco para DT2 com RCM presente, 65,8% tinham HOMA-IR (homeostasis model assessment-insulin-resistance) >2,1 e 61,8% SM. Conclui-se que a associação de TyG >8,75 e C-não-HDL ≥160 mg/dL (RCM) poderia ser de interesse para a detecção de grupos populacionais com alto risco cardiometabolico, na prevenção de DCVA e DT2.

Development of simple and sensitive score to assess the risk of pneumonia in Covid-19 patients

ABSTRACT Background: Severe pneumonia is the most common cause of intensive care unit (ICU) admission and death due to novel coronavirus (SARS-CoV-2) respiratory disease (COVID-19). Due to its rapid outbreak, units for the evaluation of febrile patients in the pre-hospital setting were created. Objective: The objective of the study was to develop a sensitive and simple tool to assess the risk of pneumonia in COVID-19 patients and thus select which patients would require a chest imaging study. Materials and Methods: We conducted a cross-sectional study in a cohort of individuals with suspected COVID-19 evaluated in a public academic healthcare center in Buenos Aires city. All adult patients with positive RT-PCR assay for SARS-COV2 between April 24 and May 19 of 2020 were included in the study. Pneumonia was defined as the presence of compatible signs and symptoms with imaging confirmation. Univariate and multivariate logistic regression was performed. A risk indicator score was developed. Results: One hundred and forty-eight patients were included, 71 (48%) received the diagnosis of pneumonia. The final clinical model included four variables: age ≥ 40 years, cough, absence of sore throat, and respiratory rate ≥ 22. To create the score, we assigned values to the variables according to their ORs: 2 points for respiratory rate ≥ 22 and 1 point to the other variables. The AUC of the ROC curve was 0.80 (CI 95% 0.73-0.86). A cutoff value of 2 showed a sensitivity of 95.7% and a specificity of 43.24%. Conclusion: This sensible score may improve the risk stratification of COVID-19 patients in the pre-hospital setting. (REV INVEST CLIN. 2021;73(1):52-8)

Evasion of Newborn Hearing Screening retest: relation with risk factors for hearing impairment / Evasão no reteste da Triagem Auditiva Neonatal: relação com indicadores de risco para deficiência auditiva

ABSTRACT Purpose: to analyze the evasion rate of the Newborn Hearing Screening program's retest, to verify whether the presence of risk indicators for hearing loss influences it, and to describe which risk indicators for hearing loss occur more frequently in these cases. Methods: 1,287 newborns/infants participated, who were screened between June 2015 and June 2018. All of them obtained "fail" as the Newborn Hearing Screening result, were referred to the retest and did not attend it. Information related to the occurrence of risk indicators for hearing loss was observed. Results: the study found that the evasion rate was of 15.23%. The presence of risk indicators for hearing loss did not show an association with non-attendance at this stage of the program (p-value = 0.087). The most frequent indicators in the cases of non-attendance at the retest were: ototoxic medication use and intensive care unit stay for more than five days. Conclusion: high evasion rate of the retest has been observed. It has been found that the presence of risk indicators did not influence the retest evasion rate. Use of ototoxic medication and stay at the intensive care unit were the most frequent indicators among those who did not attend the retest.

RESUMO Objetivo: analisar o índice de evasão no reteste do programa de Triagem Auditiva Neonatal, verificar se a presença de Indicadores de Risco para Deficiência Auditiva o influencia e descrever quais Indicadores de Risco para Deficiência Auditiva ocorrem com maior frequência nestes casos. Métodos: participaram 1287 neonatos/lactentes, triados no período de junho de 2015 a junho de 2018, que obtiveram resultado "falha" na Triagem Auditiva Neonatal, encaminhados para o reteste e não compareceram. Foram observadas informações relacionadas a ocorrência dos Indicadores de Risco para Deficiência Auditiva. Resultados: o estudo constatou que o índice de evasão foi de 15,23%. A presença de indicadores de risco para deficiência auditiva não demonstrou associação com o não comparecimento a essa etapa do programa (p-valor= 0,087). Os indicadores de maior ocorrência nos casos de não comparecimento no reteste foram: medicação ototóxica e permanência em Unidade de Tratamento Intensivo por período maior que cinco dias. Conclusão: observou-se elevado índice de evasão no reteste. Verificou-se que a presença dos indicadores de risco não influenciou no índice de evasão do reteste. O uso de medicação ototóxica e a permanência em Unidade de Terapia Intensiva foram os indicadores mais frequentes naqueles que não compareceram ao reteste.

Riesgo de diabetes mellitus de tipo 2 como indicador de desigualdad social / Risk of diabetes mellitus type 2 as indicator of social inequality

La diabetes mellitus de tipo 2 posee mayor prevalencia en países en vías de desarrollo, pues cuentan con menos recursos para enfrentar situaciones relacionadas con la incidencia de la enfermedad. Para analizar si este patrón se replica en Córdoba, se utilizó el test de Findrisk, en 2 poblaciones con diferentes niveles socioculturales, con el objetivo de caracterizarlas y compararlas en función de los indicadores de riesgo, para lo cual se realizó un estudio epidemiológico, descriptivo, transversal y de base poblacional de 743 pacientes entre 18-45 años de edad, de ambos sexos, sin diagnóstico previo de diabetes y, en el caso de las mujeres, que no estuvieran en estado gestacional. Los resultados indicaron que la diferencia entre los grupos fue significativa en la puntuación general y en las variables: perímetro de cintura, antecedentes familiares y hábitos dietarios. Se reveló la necesidad de diseñar políticas sociales en salud, que incorporen instancias formativas y participativas, para la prevención de la enfermedad, con una atención interdisciplinaria.

Diabetes mellitus type 2 has a higher prevalence in developing countries, as they have fewer resources to face situations related to the incidence of the disease. To analyze if this pattern replies in Córdoba, the Findrisk test was used, in 2 populations with different socio-cultural levels, with the objective of characterizing and comparing them regarding the risk indicators, for which an epidemiological, descriptive, cross-sectional and population- based study was carried out in 743 patients between 18-45 years, of both sexes, without previous diagnosis of diabetes and, in the case of the women they should not be pregnant. The results indicated that the difference between the groups was significant in the general score and in the variables: waist perimeter, family history and dietary habits. The necessity of designing health social policies which incorporate formative and participative instances, for the prevention of the disease, with an interdisciplinary care was revealed.

Association between Chronic Periodontitis and Oral/Oropharyngeal Cancer

Abstract The aim of this case control study was to assess the association between the extent and severity of chronic periodontitis and oral cavity and/or oropharyngeal cancer. The case group comprised 35 patients (mean age 56.1±8.4), diagnosed for oral and/or oropharyngeal cancer. The control group comprised 40 individuals (mean age 55.4±9.4) without diagnostic of cancer. All individuals were subjected to a periodontal examination, including bleeding on probing, plaque index, gingival index, probing pocket depth (PPD), clinical attachment loss (CAL), and decayed, extracted and filled teeth index (DMFT). The case group had significantly more sites with plaque. GI and BOP had similar values in both groups. The median PPD and CAL values were significantly higher for the case group. Chronic generalized periodontitis was predominant in 80% of patients with oral and/or oropharyngeal cancer. Eighty nine percent of the patients in the case group presented severe chronic periodontitis. There was no significant difference between groups for median values of DMFT. The extent and severity of chronic periodontitis remained as risk indicators for oral cavity and/or oropharyngeal cancer even after the adjustments for traditional confound factors, i.e. smoking and alcohol consumption.

Resumo O objetivo deste estudo caso controle foi determinar a associação entre extensão e severidade da periodontite crônica e câncer da cavidade oral e/ou orofaringe. O grupo caso consistiu de 35 pacientes (idade média 56,1±8,4), diagnosticados para câncer oral e/ou de orofaringe. O grupo controle foi composto por 40 pacientes (idade média 55,4±9,4) sem diagnóstico de câncer. Todos os pacientes foram submetidos a exame periodontal, incluindo sangramento à sondagem, índice de placa, índice gengival, profundidade de sondagem e nível de inserção clínica, além do índice de dentes cariados, perdidos e obturados (CPOD). O grupo caso tinha significativamente mais sítios com placa. Índice gengival e sangramento à sondagem mostraram valores similares em ambos os grupos. A mediana dos valores de profundidade de bolsa à sondagem e nível de inserção clínica foram significativamente maiores para o grupo caso. A prevalência de periodontite crônica generalizada foi de 80% em pacientes com câncer oral e/ou de orofaringe. Oitenta e nove por cento dos pacientes no grupo de caso apresentaram periodontite crônica severa. Não houve diferença significante entre os grupos para os valores medianos de CPOD. A extensão e severidade da periodontite crônica permaneceram como indicadores de risco para câncer oral e/ou de orofaringe mesmo após o ajuste para fatores de confundimento tradicional, isto é, fumo e consumo de álcool.

Indicadores clínicos de risco para a constituição do sujeito falante / Clinical risks indicators for the constitution of the speaking subject

OBJETIVO: propor indicadores clínicos de risco para a constituição do sujeito falante. MÉTODOS: dos indicadores de risco para o desenvolvimento infantil e do modelo de funcionamento dos sintomas de linguagem foram deduzidos os quatro eixos que sustentam a constituição do sujeito falante: suposição de um sujeito falante, reconhecimento do sujeito falante, reconhecimento do significante e responsividade do falante aos dizeres do outro. Dizeres parentais referidos durante as entrevistas fonoaudiológicas de usuários de três Unidades Básicas de Saúde foram agrupados por relações de semelhança, classificados e analisados segundo cada um dos quatro eixos de constituição do sujeito falante. RESULTADOS: a análise permitiu estabelecer 12 indicadores clínicos preliminares para a constituição do falante. Estes indicadores apontam para uma possibilidade de que o sujeito venha a apresentar perturbações de fala e linguagem, sustentando tanto a intervenção como ações de promoção de saúde do falante. CONCLUSÕES: os resultados permitem concluir pela importância do fonoaudiólogo na atenção básica à saúde da população e nas ações de promoção. .

PURPOSE: to propose clinical risk indicators of the constitution of the speaking subject. METHODS: from the risk indicators for child development and from the operating model of language symptoms, four axes were drawn that support the constitution of the speaking subject: the assumption of a speaking subject, recognition of the speaking subject, recognition of the significant and responsiveness of the speaker to the speech of the other. Parental information mentioned during speech therapy interviews of users of three Basic Health Units were grouped by similarity, classified, and analyzed according to each of the four axes of the constitution of the speaking subject. RESULTS: the analysis allowed us to establish twelve preliminary clinical indicators for the constitution of the speaker. These indicators point to a possibility that the subject might present speech and language disorders, supporting not only their intervention but also measures to promote the health of the speaker. CONCLUSION: the results suggest the importance of the speech therapist in the primary health care of the population and in promotional health measures. .

Enfermedad periodontal y disfunción eréctil / Periodontal disease and erectile dysfunction

La enfermedad periodontal es una enfermedad inflamatoria destructiva crónica que afecta a los tejidos de soporte del diente y es una de las infecciones crónicas más prevalentes en los humanos con la capacidad de inducir la producción de citocinas proinflamatorias, interviniendo en la regulación de las respuestas inflamatorias que aumentan los niveles de IL-6 y PCR, que da como resultado la activación de las células inflamatorias y endoteliales, pudiendo dar lugar a disfunción endotelial.La disfunción eréctil se define como la incapacidad persistente de lograr y mantener una erección suficiente para permitir una relación sexual satisfactoria y puede ser una manifestación temprana de la arteria coronaria y de la enfermedad vascular periférica, por lo que debe considerarse también como una señal de peligro potencial de la enfermedad cardiovascular. El enlace entre enfermedad periodontal y disfunción eréctil aún está en investigación y la información es muy limitada. Existen factores de riesgo (tabaco, diabetes mellitus y enfermedades cardíacas) compartidos por la disfunción eréctil y la periodontitis crónica que contribuyen a la disfunción endotelial. El objetivo de la presente revisión es dar a conocer la posible relación entre la enfermedad periodontal y la disfunción eréctil y las variables confundentes entre esta relación mediante una revisión de la literatura.

Periodontal disease is a chronic inflammatory destructive disease that affects the tissue supporting the teeth, and is one of the most prevalent chronic infections in humans. It can induce the production of pro-inflammatory cytokines, intervening in the regulation of inflammatory responses affecting the IL-6 and C-reactive protein, and finally activates inflammatory cells and endothelial cells. This can lead to endothelial dysfunction. Erectile dysfunction is defined as the persistent inability to achieve and maintain an erection sufficient to permit satisfactory sexual intercourse and can be an early manifestation of coronary artery and peripheral vascular disease, and should therefore be considered also as a potential warning sign for cardiovascular disease. The link between periodontal disease and erectile dysfunction is still under investigation and the information is very limited. There are risk factors (smoking, diabetes mellitus, and heart disease) shared by erectile dysfunction and chronic periodontitis that contribute to endothelial dysfunction. The aim of this review is to provide plausibility between periodontal disease and erectile dysfunction and confounding variables between this relationship through a literature review.

Vulnerabilidade na saude do adolescente: questoes contemporaneas / Vulnerability in adolescent health: contemporary issues

Este estudo exploratório de natureza qualitativa objetivou analisar como adolescentes percebem a realidade em termos da vulnerabilidade na saúde. Foram realizadas 17 entrevistas semiestruturadas com adolescentes de duas escolas de educação fundamental de um município do interior do estado de São Paulo. A interpretação dos dados, orientada pela análise de conteúdo, fez emergir três núcleos temáticos. Os resultados indicaram que os adolescentes compreendem a complexa interação entre a predisposição individual à vulnerabilidade para a saúde, bem como as questões relacionadas à estrutura social, o que contribui para o fortalecendo da concepção de vulnerabilidade a partir das lógicas individual, social e programática. Identificou-se que as políticas públicas, a prevenção e a assistência na adolescência não devem ser orientadas por um único referencial, mas sim pelo reconhecimento da pluralidade do ser adolescente quanto à vulnerabilidade em suas dimensões, rompendo, dessa forma, com a ideia de universalidade do processo de adolescer.

The objective of this exploratory study with a qualitative approach was to analyze how adolescents perceive reality in terms of vulnerability in respect to health. A total of 17 semi-structured interviews were staged with adolescents from two elementary-middle (k-8) schools in a city in the interior of São Paulo, Brazil. Content analysis was used to interpret the data, from which three thematic nuclei emerged. The results revealed that the adolescents understand the complex interaction between individual predisposition and health vulnerability, as well as the issues related to social structure, which contributes to strengthening the concept of vulnerability based on individual, social and programmatic logic. It was established that public policies, prevention and care provided during adolescence should not be guided by a single reference point, but instead by the plurality of the adolescent individuals concerning vulnerability in their dimensions, which should be acknowledged in order to break with the idea of the universality of the process of becoming an adolescent.

Establishment of a risk indicator evaluation system on ladder-typed coordination between man and machine / 中国实用护理杂志

Objective To establish a risk indicator evaluation system on ladder-typed coordination between man and machine.Methods Using Delphi method,40 experts were inquired by letters for two rounds,the risk indicators and weights on ladder-typed human-machine coordination were identified.Results A risk indicator evaluation system was formed by 5 first-level indicators,17 secondary indicators and 22 tertiary indicators.Conclusions This research has a high degree of participation and authority from experts with an excellent coordination,forming a risk indicator evaluation system on laddertyped coordination between man and machine,which can provide a standard principle on man-machine coordination measures for mechanical ventilation patients.

Risk indicators of periodontal disease in Korean adults / 대한구강보건학회지

OBJECTIVES: The purpose of this study was to evaluate the risk indicators of periodontal disease in a representative sample of Korean adults aged between 18 and 44 years. METHODS: Data of 6,485 adults were derived from the Fourth Korean National Health and Nutrition Examination Survey, which was conducted from 2007 to 2009. Demographic, socioeconomic, and oral health-related behavioral data were collected as independent variables. The Community Periodontal Index (CPI) was used as a dependent variable. The chi-square test and logistic regression analysis were performed to identify the relationship between the CPI and the other variables. RESULTS: Multiple logistic regression analysis revealed that periodontal pocket formation (4 mm or more) was related with sex, age, and income level, irrespective of whether the mother engaged in economic activities in childhood, smoking experience, dental flossing, and use of interdental brushes. The subjects in the lowest-income quartile and those who were current smokers had a higher risk of pocket formation (odds ratios, 1.43 and 1.74, respectively) than those in the highest-income quartile and those who had no smoking experience, respectively. CONCLUSIONS: This study confirmed various risk indicators of periodontal disease in Korean adults, using Korean national survey data. Smoking cessation, dental flossing, and efforts to decrease socioeconomic inequality should be encouraged to decrease the risk of periodontal disease.