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1.
Clinical Pediatric Hematology-Oncology ; : 21-36, 2017.
Article in Korean | WPRIM | ID: wpr-788599

ABSTRACT

Pediatric renal tumors represent a diverse group, which include Wilms' tumor (WT), renal cell carcinoma (RCC), clear cell sarcoma of the kidney (CCSK), congenital mesoblastic nephroma, malignant rhabdoid tumor of the kidney (MRTK) and primitive neuroectodermal tumor. WT (85%) and RCC (8%) are the most prevalent types. WT predominates among the 1- to 10-year age group, but RCC exceeds WT in children over age 10 years. Pediatric renal tumors are genetically, histologically and clinically heterogeneous. The overall survival for children with localized WT is currently more than 90%, whereas poorer survival rates are observed for anaplastic WT, metastatic WT, metastatic CCSK, MRTK, metastatic RCC and relapsed WT. Therefore risk-stratified treatment is important to minimize treatment morbidity while preserving survival. This review focuses on distinct characteristics of each tumor type and optimal stratified treatment.


Subject(s)
Child , Humans , Carcinoma, Renal Cell , Kidney , Nephroma, Mesoblastic , Neuroectodermal Tumors, Primitive , Rhabdoid Tumor , Sarcoma, Clear Cell , Survival Rate , Wilms Tumor
2.
Clinical Pediatric Hematology-Oncology ; : 21-36, 2017.
Article in Korean | WPRIM | ID: wpr-197959

ABSTRACT

Pediatric renal tumors represent a diverse group, which include Wilms' tumor (WT), renal cell carcinoma (RCC), clear cell sarcoma of the kidney (CCSK), congenital mesoblastic nephroma, malignant rhabdoid tumor of the kidney (MRTK) and primitive neuroectodermal tumor. WT (85%) and RCC (8%) are the most prevalent types. WT predominates among the 1- to 10-year age group, but RCC exceeds WT in children over age 10 years. Pediatric renal tumors are genetically, histologically and clinically heterogeneous. The overall survival for children with localized WT is currently more than 90%, whereas poorer survival rates are observed for anaplastic WT, metastatic WT, metastatic CCSK, MRTK, metastatic RCC and relapsed WT. Therefore risk-stratified treatment is important to minimize treatment morbidity while preserving survival. This review focuses on distinct characteristics of each tumor type and optimal stratified treatment.


Subject(s)
Child , Humans , Carcinoma, Renal Cell , Kidney , Nephroma, Mesoblastic , Neuroectodermal Tumors, Primitive , Rhabdoid Tumor , Sarcoma, Clear Cell , Survival Rate , Wilms Tumor
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