Comprehensive analysis of clinicopathologic and sonographic features in thyroid cancer with skip lymph node metastasis: establish and assessment of a prediction nomogram

Abstract Lateral Lymph Node Metastasis (LLNM) is common in Papillary Thyroid Carcinoma (PTC) and is associated with a poor prognosis. LLNM without central lymph node metastasis as skip metastasis is not common. We aimed to investigate clinicopathologic and sonographic risk factors for skip metastasis in PTC patients, and to establish a nomogram for predicting the possibility of skip metastasis in order to determine the therapeutic strategy. We retrospectively reviewed the data of 1037 PTC patients who underwent surgery from 2016 to 2020 at a single institution. Univariate and multivariate analyses were used to identify the clinicopathologic and preoperative sonographic risk factors of skip metastasis. A nomogram including the risk factors for predicting skip metastasis was further developed and validated. The incidence of skip metastasis was 10.7%. The univariate and multivariate analyses suggested that gender (p = 0.001), tumor location (p = 0.000), extrathyroidal extension (p = 0.000), and calcification (p = 0.000) were independent risk factors. For papillary thyroid microcarcinoma, tumor location (p = 0.000) and calcification (p = 0.001) were independent risk factors. A nomogram according to the clinicopathologic and sonographic predictors was developed. The receiver operating characteristic curve indicated that AUC was 0.824 and had an excellent consistency. The calibration plot analysis showed a good performance and clinical utility of the model. Decision curve analysis revealed it was clinically useful. A nomogram for predicting the probability of skip metastasis was developed, which exhibited a favorable predictive value and consistency. For the female PTC patient, tumor located at the upper pole is more likely to have skip metastasis. Surgeons and sonographers should pay close attention to the patients who have the risk factors. Evidence level: This article's evidence level is 3. Level 3 evidence is derived from nonrandomized, controlled clinical trials. In this study, patients who receive an intervention are compared to a control group. Authors may detect a statistically significant and clinically relevant outcome.

Contralateral lymph node metastasis: A rare skip pattern

Neck lymph node metastasis is the most critical factor influencing the survival and prognosis of oral squamous cell carcinoma. The outcome of patients with lymph node metastases occurring after excision or radiotherapy of the primary tumor is poor. In the absence of ipsilateral nodal metastases, contralateral lymph neck metastasis is extremely rare. Reports of skip metastases have been recorded for lesions of the tongue and floor of the mouth as there is free communication between the two sides of the tongue. Intraoperative frozen sections of neck nodes have been used as a modality for the detection of occult metastases and to guide the extent of neck dissection but have not provided satisfactory results. The case described in this report is a rare phenomenon that demonstrates a well-lateralized clinically advanced buccal mucosa carcinoma with histologically proven node-negative neck but exhibited contralateral positive neck after a span of 1 month.

Investigating the characteristics of skip N2 metastasis in NSCLC / 中华胸心血管外科杂志

Objective To analysis the clinicopathological features of skip N2 metastasis in NSCLC in our clinical center,therefore guide for clinical decision making for NSCLC patients.Methods A total of 120 NSCLC patients with N2 metastasis treated by surgery were enrolled from January 2017 to May 2018,of which 55 were males and 65 were females.The mean age of them were (58.36 ± 11.34) years old.36 patients had skip N2 metastasis,accounting for 30％ of patients with N2 metastasis.48 patients had a history of smoking or a definitive history of second-hand smoke exposure,compared with other 72 patients.Collected pre-and post-operation clinical data of those patients,and carried out relevant statistical analysis.Results Among the NSCLC with skip N2 metastasis,it occulted more frequently in right lower lobe and peripheral lung cancer.The main pathological type was adenocarcinoma with acinar subtype.The most cases of skip N2 metastasis were characterized by single N2 station metastasis.Age of patients showed a significant difference between the two groups(P =0.049).Gender,smoking history,T staging of lung cancer,pathological type and involvement of pulmonary membrane showed no statistic difference between the two groups(P ＞ 0.05).Conclusion Patient with skip N2 metastasis seemed to be elder,and the lesions of those patients were more likely to be lung adenocarcinoma in the right lower lobe and peripheral lung cancer,often involved single N2 station.The lung cancer in right upper lobe often skipped to level R2 + R4,which in right middle lobe often skipped to levels R2 + R4 and 7,in right and left lower lobes skipped to level 7,in the left upper lobe often skipped to level 5.

Analysis of the relationship between ultrasonographic features and cervical lymph node skip metastasis of papillary thyroid micro-carcinoma / 中华肿瘤杂志

Objective@#To investigate the correlation between cervical lymph node skip metastasis with ultrasonographic characteristics of papillary thyroid micro- carcinoma (PTMC).@*Methods@#We reviewed ultrasonographic features of 385 primary PTMC and cervical lymph node metastasis, confirmed by pathology in Tianjin Medical University Cancer Institute and Hospital, to evaluate the efficacy of ultrasonography in the diagnosis of cervical lymph node metastasis of PTMC patients. The relationship between ultrasonographic features of primary lesions and skip metastasis of cervical lymph nodes was analyzed by χ2 test and multiple factor Cox regression.@*Results@#Among the 385 cases of PTMC patients with cervical lymph node metastasis, 231 cases were central lymph node metastasis alone, 31 cases were lateral cervical lymph node metastasis alone, 123 cases were both central and lateral cervical lymph node metastasis. Among the 354 cases without skip metastasis of cervical lymph nodes, 48 cases were level Ⅱ, 92 cases were level Ⅲ, 83 cases were level Ⅳ, 9 cases were level Ⅴ, 354 cases were level Ⅵ. Among the 31 cases with skipping metastasis of cervical lymph nodes, 12 cases were level Ⅱ, 14 cases were level Ⅲ, 14 cases were level Ⅳ, 1 case was level Ⅴ. The sensitivity and specificity of preoperative ultrasonography in the diagnosis of central cervical lymph node metastasis were 46.3% and 66.7%, respectively, and those of lateral cervical lymph node were 91.0% and 87.8%, respectively. Univariate analysis showed that the abutment/perimeter, diameter and location of PTMC were significantly associated with skip metastasis (P<0.05), multivariate analysis showed that abutment/perimeter and location of PTMC were significantly associated with skip metastasis (P<0.05).@*Conclusions@#The sensitivity and specificity of preoperative ultrasound diagnosis for lateral cervical lymph node metastasis of PTMC is higher than that of central metastasis. PTMC with abutment/perimeter ≥1/4 and upper portion location are prone to skip metastasis.

Skip metastasis to portocaval and retropancreatic space in T2 cecal cancer without regional and principle lymph node involvement

Lymph node metastasis in early colon cancer is relatively low. Furthermore, skip metastasis beyond principle lymph node is very rare. This is a case of early cecal cancer with skip metastasis to portocaval and retropancreatic space, without regional lymph node metastasis. A 69-year-old female diagnosed as cecal adenocarcinoma. The imaging study revealed as early cecal cancer without enlargement of regional lymph node. However, there is enlargement of portocaval lymph node and high fluorodeoxyglucose (FDG) uptake in positron emission tomography scan image. Right hemicolectomy with extended lymph node dissection was done including retropancreatic, portocaval and hepatoduodenal ligament lymph node. Though whole abdominal cavity exploration was done, there was no evidence of other synchronous cancer. The final pathologic findings revealed the poorly differentiated adenocarcinoma with invasion of submucosal layer and focally superficial layer of muscularis propria. Two of total 27 lymph nodes were involved by metastastatic adenocarcinoma which were from portocaval and retropancreatic space. The detailed preoperative imaging study could find unexpected lymph node metastasis beyond range of routine lymph node dissection. Even though the preoperative clinical stage is relatively early, the detailed and sufficient evaluation for clinical and imaging findings is important not to ignore skip metastasis.

Clinical efficacy of two skip-level anterior cervical discectomy and fusion in treatment of two-level noncontiguous cervical spondylotic myelopathy / 局解手术学杂志

Objective To evaluate the clinical and radiological outcomes of skip-level anterior cervical discectomy and fusion(ACDF) for the treatment of two-level noncontiguous cervical spondylotic myelopathy(CSM).Methods There were 34 patients with two-level noncontiguous CSM underwent skip-level ACDF in our department from January 2014 to December 2016.The clinical outcome including surgery time, intraoperative blood loss,Japanese Orthopaedic Association(JOA) scores,Neck dysfunction index(NDI),the improvement rate of JOA,segment lordosis,fusion rate and Odom's criteria were evaluted.Results The surgery time was from 92 minutes to 125 minutes,mean operative time 103.28 minutes;the intraoperative blood loss was 50 to 150 mL,with average blood loss of 90 mL.The cervical spine lateral radiographs showed that the cervical physiological curvature had restored.The patients were followed up for average 6 months.The fusion rate of was 94.1％ at the lastest follow-up.No cages subside,implant failure or migration and infection occured.The JOA and NDI scores at the latest follow-up were(14.21±0.732) and (3.26±1.14),respectively,the JOA scores improvement rates was 58.62％.The segmental lordosis before surgery was(10.75±1.132)°,the one after surgery was(15.61±1.312)°,the difference was significant(P<0.05).The Odom's criteria at the lastest follow-up showed that excellent in 21 patients,good in 9 patients and fair in 4 patients,with excellent and good rate of 88.2％.Conclusion Skip-level ACDF can achieve good clinical and radiological outcomes including a high fusion rate and well maintainence of spinal curvature and intervertebral height for patients with two-level noncontiguous CSM.

Predictive factors of skip metastasis to lateral with leaping central lymph node in papil-lary thyroid carcinoma / 中国肿瘤临床

Objective:To retrospectively analyze the regularity and risk factors of skip metastasis (central lymph node negative and lat-eral lymph node positive) in papillary thyroid carcinoma (PTC). Methods:A total of 521 PTC patients underwent total thyroidectomy and central plus lateral lymph node dissection at The First Affiliated Hospital of Chongqing Medical University from January 2013 to De-cember 2016. Clinicopathological characteristics of the patients were collected and analyzed. Results:Skip metastasis rate of PTC was 8.3％(43/521). Tumors in the upper lobe (OR=3.401, 95％CI:1.770-6.536;P=0.001) and in the lateral part (OR=3.424, 95％CI:1.182-9.920;P=0.023) of the thyroid, as well as age above 45 (OR=2.856, 95％CI:1.488-5.482;P=0.002), were independent risk factors for skip metastases for this disease. Clinically node-negative (cN0) PTC patients with tumors in the upper lobe had higher possibility of skip metastases than those with clinically involved lateral neck nodes(cN1b) (P=0.022). Conclusion:Skip metastasis of PTC is not un-common. Thus, preoperative clinical assessment and imaging examination for lateral lymph node is necessary, especially for PTC pa-tients who are above 45 years old and with tumors in the upper lobe and/or unilateral area of thyroid. The lateral lymph node dissec-tion should be performed when necessary.

Delayed Spondylodiscitis Presenting as a Skip Lesion

Spondylodiscitis is believed to be caused by an infection that affects vertebral bodies and the intervening intervertebral disc. Usually, typical spondylodiscitis involves a mobile vertebra-disc-vertebra unit, and in most cases, the condition is managed successfully by surgical intervention and intravenous antibiotic therapy. Here, the authors report an unusual case of a spondylodiscitis presenting as a skip lesion, which progressed from L4/L5 to L1/L2, despite open surgical biopsy and empirical intravenous antibiotics. Possible pathogenic mechanisms of this unique case are discussed and a review of the pertinent literature is included.

The correlation of inflammatory severity between appendiceal orifice inflammation and ulcerative colitis / 中华消化内镜杂志

Objective To evaluate the correlation of inflammatory severity between appendiceal ori-fice inflammation(AOI)and ulcerative colitis(UC). Methods A retrospective analysis of the patients who were diagnosed as UC was conducted to investigate the correlation of the severity of inflammation between AOI and UC by linear trend test. Results The detective rate of UC during the above period was 2. 3%(991/ 42 928),with the patient number of 991.Appendiceal orifice observation did not perform in 45 cases due to patients reasons. In 946 patients,260 cases were diagnosed as having AOI,which accounted for 27. 5%of the total cases examined.AOI positive rates were significantly different between groups based on endoscopic severity standard(χ2 = 27. 39,P0. 0125],both significantly higher than that in mild group[4. 3%(4/ 92),P<0. 0125]. In linear regression analysis,regression coefficient was 0. 32,χ2return = 29. 48(P<0. 05)and χ 2partial =31. 66(P<0. 05),which proved a positive correlation between the two drawn existed but not a simple linear relationship. Conclusion AOI is a sign in some active UC patients. Its severity of inflammation can reflect the degree of inflammation in UC,which may offer a terminal point when treating a slice of UC individuals and giving a signal of its relapse.

Forced egg retention and oviposition behavior of malaria, dengue and filariasis vectors to a topical repellent diethyl-phenylacetamide.

Egg retention and oviposition behavior of four species of mosquito vectors viz., Anopheles stephensi, Aedes aegypti, Aedes albopictus, and Culex quinquefasciatus to a topical insect repellent diethyl-phenylacetamide (DEPA) at 0.1-1000 mg/L was investigated under laboratory conditions. Based on oviposition activity indices, DEPA demonstrated concentration dependent oviposition deterrent effect to A. stephensi (-0.18 to -0.97), A. aegypti (-0.18 to -0.91) and A. albopictus (-0.50 to -0.98) females. In contrast, positive oviposition response by C. quinquefasciatus (+0.39 and +0.70) was observed respectively at 0.1 and 1 ppm, while 10 ppm of DEPA on water received 50% lesser egg rafts than control. Gravid Culex females laid no egg rafts at 100 and 1000 ppm DEPA treated bowls effecting 100% oviposition deterrence. Test mosquito females deposited most of their eggs (>90%) in the absence of repellent odour, while DEPA odour on water surface forced them to retain huge numbers of eggs. Females of A. aegypti, A. albopictus and A. stephensi retained 49, 67 and 50% of total eggs, respectively throughout the experiment. Egg retention by Culex females due to DEPA on the water surface was ca. 65%, equivalent to 4 egg rafts. Therefore, DEPA at lower concentrations could effectively disturb the oviposition by these vectors. Application of repellents in small water bodies would help in reducing the population build up of mosquitoes near human households and could be useful in the integrated management of mosquito vectors.

Impact of breakfast skipping toward children health: a review.

Breakfast skip is an activity that ignores the meal in the morning before start works, most previous studies assumed that it’s affect children health outcome. This study aim to inform the readers that how breakfast skip influence adolescent health status particularly weigh gain. This data was collected from published papers between January 2008 to 2014 used Google scholar databases. The articles were limited to English language only which focus on breakfast skip, obesity and children as keywords. Breakfast skipping has great influence to the children body particularly body mass index (BMI). Those who omit breakfast will less satiety, increase appetite and having large portion at subsequent meals, consequently total energy density higher than breakfast eaters. Breakfast skipping will lead children to the adverse health outcome especially weigh gain. Conversely, breakfast consumption is a way to ensure that they meet their daily nutrient and energy intakes.

Lymph node metastasis: A bearing on prognosis in squamous cell carcinoma.

Nodal status is a significant predictor for survival of patients with oral squamous cell carcinoma (SCC), sentinel lymph node (SLN) biopsy, step sectioning of SLNs, and immunohistochemistry have changed the detection of tumor deposits in lymph nodes (LNs). The extent of LN metastasis is a major determinant for the staging and the prognosis of most human malignancies and often guides therapeutic decisions. Metastasis to regional lymph node (RLN) is a complex process. It is often associated with several clinical and pathological characteristics. The involvement of RLN is often, a harbinger for increased risk of metastasis. New knowledge in this area can enable the clinicians and pathologists to study and treat tumors in a more directed fashion. A molecular approach to factors that predicts the likelihood of RLN metastasis could eliminate the reoccurrence of the tumor in the form of “micrometastasis” and “skip” metastasis. The aim of this review is to discuss different modes of spread of metastasis in SCC.

Can One Predict the Incidence of Metastasis in Oral Squamous Cell Carcinoma Patients Using Tumor Thickness.

Aim: The present study was undertaken with the purpose to assess the correlation between the presence of lymph node metastases and the size of tumor and the thickness of the tumor mass. Methods: The study included 80 consecutive cases of oral squamous cell carcinoma, who underwent radical neck dissection. The various level of lymph nodes in these cases were checked for metastases, which was then correlated with the size of tumor and the thickness of the tumor. Results: In this study it was revealed that there is a statistically non-significant (p = 0.3204) correlation between size of the tumor and regional cervical lymph node metastases, but a significant correlation (p = 0.0148) between thickness of the tumor and regional cervical lymph node metastases was observed. Conclusion: Thus we conclude that the tumor thickness was more in cases with skip metastasis than in cases without skip metastasis and tumors greater than 10mm in thickness have more chances of regional metastases.

Precisão do sistema de correção informatizada do teste palográfico - SKIP / Reliability of the palográfico test computerized correction system - SKIP

O Palográfico é um teste gráfico expressivo que avalia características de personalidade e é utilizado em avaliações psicológicas para diversos fins, principalmente em processos com grande volume de candidatos. O objetivo desta pesquisa foi verificar a precisão do Software de Correção Informatizada para o Palográfico (SKIP) por meio da comparação entre dois métodos de avaliação: o tradicional (manual) e o eletrônico. A amostra foi composta por 103 pessoas de ambos os sexos com idades entre 18 e 63 anos e escolaridade do Ensino Fundamental ao Superior, que participaram de avaliações psicológicas para obtenção da CNH. As medidas foram submetidas à Correlação de Pearson e ao Teste t de Student. Todas as correlações entre os dois métodos de avaliação foram muito altas (acima de 0,943) e as diferenças entre as médias não foram estatisticamente significantes. Os resultados apontaram altos índices de precisão do SKIP para a mensuração das características quantitativas do Teste Palográfico...

The Palográfico is an expressive graphic test that assesses personality characteristics and is used in psychological assessments for various purposes, especially in cases with large volume of examinees. The objective of this research was to determinate the reliability of the Computerized Correction Software for Palográfico Test (SKIP), through the comparison of two methods of evaluation: the traditional (manual) and the electronic. The sample was composed by 103 participants of both sexes aged between 18 and 63 years, whose education varied from elementary school to college, and who participated in psychological assessments to obtain CNH. Measures were submitted to the Pearson correlation and Student's t test. All correlations of the two assessment methods were very high (above 0,943) and the differences between means were not statistically significant. The results showed high reliability indices of SKIP to measure the quantitative characteristics of Palográfico Test...

FDG-PET/CT Complements Bone Scan with Respect to the Detection of Skip Metastasis of Osteosarcoma: A Case Report / 대한골관절종양학회지

Skip lesion is not uncommon feature in osteosarcoma and considered to be importantly associated with poor prognosis factor, and thus, should be excised with the main mass. The accurate pre-operative evaluation of the intramedullary extent of osteosarcoma is essential, because it determines the level of bone resection. Among the reliable detection methods, bone scan has a drawback of high rate of false negative results and regional MRI has a difficulty to cover the whole involved lesions without clinical suspicion. The authors report a case of osteosarcoma of the distal femur with a proximal skip lesion that was not detected by either regional MR imaging or by bone scan, but which was visualized by FDG-PET/CT.

Predictive factors for lateral lymph node metastasis in papillary thyroid microcarcinoma / 中华内分泌代谢杂志

Objective To find the clinical and histopathological predictive factors for lateral lymph node ( LN ) metastasis in thyroid papillary microcarcinoma( PTMC ).Methods From January 2007 to December 2010,141 patients with PTMC underwent central and lateral LN dissections were enrolled in the study.The data from the cases were analyzed retrospectively to determine the predictive factors for lateral LN metastasis.Results Among the aforementioned cases,37 cases ( 26.2％ ) were PTMC with the presence of multifocality,24 ( 16.9％ ) Hashimoto thyroiditis,84 ( 59.6％ ) central LN metastasis,56 ( 39.7％ ) lateral LN metastasis.Multifocality,central LN metastasis,underlying Hashimoto thyroiditis,and upper pole location were significantly related to lateral LN metastasis in univariate analysis( P＜0.05 ).These four factors were also found to be independent predictive factors for lateral LN metastasis in multivariate analysis( P＜0.05 ).9(6.4％ ) of there patients were found to show skip metastasis in which there was lateral LN metastasis but no central LN metastasis.The upper pole location was statistically significantly associated with skip metastasis.Conclusions Patients with multifocality,central LN metastasis,underlying Hashimoto thyroiditis,and upper pole location should be paid more attention to the status of lateral LN.Skip metastasis occurs in a minority of patients with PTMC.Even if there is no central LN metastasis,patients with upper pole lesion should be searched carefully for the lateral cervical LN metastasis.

Ewing sarcoma of the left big toe with trans-articular skip lesion: A case report.

We report the case of the patient who had Ewing Sarcoma in whom radiological and hystopathological appearances revealed a tumor mass in the left big toe along with trans-artikular skip lesion on the left diaphysis of tibia. In Cipto Mangunkusomo Hospital since 1995 until 2004 we have found 20 Ewing sarcoma cases, but only one skip lesion Ewing sarcoma was found. The diagnosis of transarticular skip lesion in association of Ewing sarcoma was confirmed in clinicopathological conferrence. The initial evaluation of all patients included the recording of the medical history, physical examination, and hematological studies. Radiographs of the chest and the site of the primary tumor were made routinely. Systemic staging was performed with use of total-body bone scan. Ray amputation of left big toe and open biopsy from mass of mid-shaft of tibia had been done to confirm the diagnosis. The patient underwent induction chemotherapy and above knee amputation. Ten months after diagnosis, he died because of advanced-distant metastasis.

The Pattern of Cervical Lymph Node Metastases in Papillary Thyroid Cancer / 대한내분비외과학회지

PURPOSE: Cervical lymph node metastases are quite common in papillary thyroid cancer and the spreading route of a metastasis is usually in a sequential fashion. However, skip metastasis is not uncommon in node-positive papillary thyroid cancer. The goal of this study was to evaluate the pattern of cervical lymph node metastases in papillary thyroid cancer. METHODS: A total of the 265 patients with papillary thyroid carcinoma that underwent a total thyroidectomy and cervical lymph node dissection between January 2006 and August 2007 were enrolled in the study. Medical records were reviewed for analyses of the pattern of cervical lymph node metastasis. RESULTS: Cervical lymph node metastases were noted in 39.2% of the total cases and in 27.9% of the 197 patients that had only central lymph node dissection and 48.5% of the 68 patients that had central and lateral lymph node dissections. Among the cases of central and lateral node dissection, skip metastasis, lateral lymph node metastasis without central lymph node metastasis, was observed in 4 (5.8%) of the cases and a false positive result of node dissection was confirmed in 19 (28.1%) cases. CONCLUSION: For complete surgery of papillary thyroid carcinoma, a thorough examination of the cervical lymph node is required. Acareful consideration of the possibility of skip metastasis and false positive results in cervical lymph node dissection, especially in the lateral compartment, is necessary.

Study on Present Situation and Countermeasures of Skipping Classes among Medicos and Non-medicos in Guangzhou / 中华医学教育探索杂志

In order to understand deeply the present situation and countermeasures of skipping classes among undergraduates,this paper uses questionnaire investigation,mathematical statistics and logical analysis to study the medicos and non-medicos in Guangzhou.The result shows it is very important to pay more attention to education,improve the quality of teaching,and so on.

Total Colonic Aganglionosis With Skip Area

Early recognition and surgical treatment of Hirschsprung's disease prevents serious mortality and morbidity from enterocolitis and obstruction. Usually this disease is chractrized by a single aganglionic segment of colon extending distally to anal margin. In surgical treatment, the surgeon performs frozen biopsy to confirm whether there are ganglion cells or not. If there are intervening ganglionic area in aganglionic bowel, there are much confusion in diagnosis and treatment. The authors experienced one case of total colonic aganglionosis with skip area. A transverse loop colostomy was made to a 7 day-old male baby with colon perforation due to Hirschsprung's disease. But intestinal obstruction persisted and it took 2 more operations to find out the ture nature of the disease. There were aganglionic segments from anal margin to terminal ileum 3.7cm proximal from ileocecal valve. But the entire transverse colon and appendix were normally ganglionated.