Correlation Study of “Dose-effect-toxicity”of Miao Medicine Wikstroemia indica on Anti-immune Inflammation of Mice before and after Processed by “Sweat Soaking Method ” / 中国药房

OBJECTIVE：To investigate the “dose-effect-toxicity”correlation of Miao medicine Wikstroemia indica before and after processed on anti-immnue inflammation of mice . METHODS ：Mice were divided into blank group ，model group ，ethanol extract of W. indica raw product groups 1-6，ethanol extract of W. indica processed product by “sweat soaking method ”groups 1-6 （hereinafter called “raw groups 1-6”“processed groups 1-6”for short ，drug dosage were 0.13，0.20，0.26，0.52，1.04，2.6 g/kg）， positive group （cyclophosphamide，36.4 mg/kg），with 10 mice in each group. Except for blank group ，other groups were given 1％ 2，4-dinitrofluorobenzene-acetone-sesame oil mixed solution to induce delayed type hypersensitivity model. After modeling， blank group and model group were given constant volume of 1.0％ CMC-Na solution intragastrically ，and administration groups were given relevant medicine 20 mL/kg intrag astrically，oncea day ，for consecutive 5 d. A fter last medication ，ear swelling degree of mice were recorded ；the inhibition rate of swelling degree， half effective dose （ED50） and 95％ confidence 158-02-32）； interval（CI）of raw and processed products were calculated ； the weight of heart ，liver，spleen，lung and kidney were measured and the indexes of organs were calculated ；ELISA 1161472062@qq.com and modified chemical oxidation method were used to determine the serum levels of inflammatory factors （TNF-α， IL-10） and liver and renal function indexes （ALT，AST， TBIL，BUN，CREA）. RESULTS：Compared with blank group ，the degree of ear swelling in the model group was significantly increased（P＜0.05）. Compared with model group ，ear swelling degree of mice were decreased significantly in different doses groups of ethanol extract of raw and processed products of W. indica （P＜0.05）. The inhibition rate of swelling increased with the increase of dose ，ED50 and 95％CI of delayed hypersensitivity ear swelling were 0.239 6（0.129 0，0.445 2）g/kg and 0.147 3（0.076 8，0.282 7）g/kg，respectively. Compared with blank group ，liver index and serum TNF-α level of mice were increased significantly in model group ，while lung index and serum IL- 10 level were decreased significantly （P＜0.05）. Compared with model group ，the levels of liver indexes （positive group ，raw group 3，processed groups 1-6）and serum TNF-α levels（positive group ，raw groups 1-3，processed groups 1-4） were decreased significantly in different administration groups ；while the levels of lung indexes （positive group ，raw groups 3-6 and processed groups 3-6），serum IL- 10 levels（raw groups 1，2，4 and 5，processed groups 2-6），ALT，AST，BUN and CREA levels （raw groups 4-6），TBIL levels （raw groups 3-6 ）were increased significantly （P＜ 0.05）. CONCLUSIONS ：The ethanol extract of raw product of W. indica has certain anti-inflammatory activity ，and has certain hepatorenal toxicity to mice ，with certain “dose-effect-toxity”correlation. The ethanol ectract of processed product of W. indica has certain anti-inflammatory activity too ，but its hepatorenal toxicity was lower than raw product. The “sweat soaking method ” possesses the function of “retaining efficiency and reducing toxicity ”for processing W. indica .

SMART: a service-oriented architecture for monitoring and assessing Brazil's Telehealth outcomes

Abstract Introduction Brazilian Telehealth Program was instituted by the Ministry of Health in 2007. Its initial structure was composed by nine telehealth centers administered by public higher education institutions. No standards, processes, applications or quality indicators had been defined since its creation. All this, combined with the decentralization of the centers, led each one of them to develop their own system, with different programming languages and architectures. The lack of regulation and integration of the information with the Ministry of Health made it difficult to evaluate the program. In this context, this paper describes the specification, implementation and validation of an architecture, entitled SMART, to integrate the various telehealth platforms developed by the centers. Such architecture aims to standardize information so that the Ministry of Health can monitor and evaluate the results of Telehealth actions. Methods SMART's architecture consists of four main components: a web tool for data manipulation; a web service to receive the center's production data; a component responsible for converting the received data into decision support data; and a component that collects data from external sources to compose the data warehouse. Results The architecture was validated with performance tests, which were executed under extreme workloads. The results of the experiments were summarized in order to attest SMART's effectiveness. Conclusion The analysis of the results obtained on real data shows that the project's performance remained stable under the workloads and its high quality was proven due to the absence of errors during the experiments.

SOA-BD: Service Oriented Architecture for Biomedical Devices

Introduction: The communication of information systems with biomedical devices has become complex not only due to the existence of several private communication protocols, but also to the immutable way that software is embedded into these devices. In this sense, this paper proposes a service-oriented architecture to access biomedical devices as a way to abstract the mechanisms of writing and reading data from these devices, thus contributing to enable the focus of the development team of biomedical software to be intended for its functional requirements, i.e. business rules relevant to the problem domain. Methods The SOA-BD architecture consists of five main components: A Web Service for transport and conversion of the device data, Communication Protocols to access the devices, Data Parsers to preprocess data, a Device Repository to store data and transmitted information and Error handling, for error handling of these information. For the development of SOA-BD, technologies such as the XML language and the Java programming language were used. Besides, Software Engineering concepts such as Design Patterns were also used. For the validation of this work, data has been collected from vital sign monitors in an Intensive Care Unit using HL7 standards. Results The tests obtained a difference of about only 1 second in terms of response time with the use of SOA-BD. Conclusion SOA-BD achieves important results such as the reduction on the access protocol complexity, the opportunity for treating patients over long distances, allowing easier development of monitoring applications and interoperability with biomedical devices from diverse manufacturers.

SOA framework-based design of personalized information service in medical library / 中华医学图书情报杂志

Personalized information service has become an important interest in medical library due to the rapid development of Internet technology. The SOA framework-based personalized information service system architecture was proposed by analyzing the contents and characteristics of personalized information service in medical library, which is characterized by standards, loose couple, low cost modification and operating maintenance, and can thus ensure both personalized information service and daily professional activities in medical library.

Design of medical library information service model according semantic Web and SOA / 中华医学图书情报杂志

An information service model of subject librarians was proposed according to the semantic-linked data, changing retrieval methods of ontology technology users, and ontology.This model provides an open application in-terface by making use of SOA for the semantic-based information service, establishes the expanded semantic-linked relation between resources by constructing the driving engine and knowledge database based on linked data technolo-gy, and builds subject librarian platform, medical expert platform and subject user platform.Subject librarians can thus provide intelligent information retrieval service for medical users at semantic level under the help of medical experts.

Equipment department management information system based on B/S architecture:purchase process management / 医疗卫生装备

Objective To develop an equipment purchase process management module based on B/S architecture to standardize hospital equipment purchase process and promote hospital informatization. Methods Service-oriented architecture (SOA) was adopted as the main architecture, and internet information service (IIS) manager was used as the publishing tool.Results All the departments could visit the system through hospital intranet and perform on-line equipment purchase and inquiry for progress.Conclusion The system facilitates the inquiry of all departments for the progress of equipment purchase, and standardizes and optimizes the equipment purchase process.

Equipment department management information system based on B/S architecture:consumables supermarket management / 医疗卫生装备

To establish a consumables supermarket management system to realize the informatized management of the consumables supermarket. The system used SOA as the main architecture, and IIS manager as the pub-lishing tool. The system had the workload, materials and financial resources decreased while the efficiency in-creased, and made the supervisor master the sale information timely. Consumables supermarket informatized management may decrease the hospital's needs for current capital as well as the links, while increase the hospital effi-ciency greatly.

One Network Resource Sharing Architecture of Traditional Chinese Medicine Industry / 世界科学技术-中医药现代化

Currently, the basic network resource of the entire traditional Chinese medicine (TCM) industry is fragmented. Issues of data unify are not easily resolved. It seems that there is no new breakthrough in key technologies, especially on the problem of data sharing and resources' integration. In this context, a method of medical information data sharing is advocated to solve the problem. We use the RESTful style to define resources of the pharmaceutical industry, which is based on the UDDI Web services standards. The objective of this paper is to create a method of TCM resource URL defined and exchanged. Finally, this paper provided an easy way for TCM data network sharing.

MODELO ARQUITECTÓNICO PARA INTEROPERABILIDAD ENTRE INSTITUCIONES PRESTADORAS DE SALUD EN COLOMBIA / ARCHITECTURAL MODEL FOR INTEROPERABILITY BETWEEN HEALTHCARE SERVICE PROVIDERS IN COLOMBIA

En la actualidad Gobiernos, IPS y desarrolladores de software enfrentan la necesidad de mejorar la eficiencia de los sistemas de información en salud mediante una adecuada gestión de la información y la implementación de TICS. Una de las áreas de interés, es el desarrollo de perfiles de interoperabilidad que permita intercambiar información y mejorar la colaboración entre los diferentes actores del sistema de salud. El objetivo del presente artículo es definir y validar un modelo arquitectónico de interoperabilidad entre sistemas de información de IPS en Colombia. El modelo, sustentando en normatividad Colombiana, sugiere el uso de SOA como referencia para definir la arquitectura software y el estándar HL7 para el intercambio de mensajes y documentos clínicos. Posteriormente se evalúa el modelo mediante un grupo de profesionales con experiencia en desarrollo de sistemas de información y una prueba piloto basada en dos escenarios de interoperabilidad en tres IPS de Popayán. El modelo busca aportar una metodología de modelamiento y desarrollo de software en IPS y empresas desarrolladoras, mejorando así el nivel de entendimiento y control sobre las transacciones de información presentes en la prestación de servicios.

Nowadays governments, health services organizations and software developers face the need to improve the efficiency of information systems in health through information management and ICT implementation. One of the areas of interest is the development of interoperability profiles that allow exchange information and improve collaboration between different actors in the health system. The aim of this paper is to define and validate an architectural model of interoperability between information systems on IPS in Colombia. The model, grounded in Colombian legislation, suggests the use of SOA as a reference to define the software architecture and HL7 standard for the exchange of messages and clinical documents. Subsequently the model is evaluated by a group of professionals with experience in information systems development and piloted based on two interoperability scenarios in three IPS of Popayán. The model aims to provide a methodology for software modeling and development among health services organizations, improving the level of understanding and control over information transactions present in the delivery of services.

Design of Regional Cooperative Healthcare System / 医疗卫生装备

Objective To build a regional cooperative healthcare system in order to make the best use of the limited medical resources,reduce the cost,and improve the quality of medical treatment.Methods Data warehouse and virtual database were used to build regional data center and realize data integration of hospital information system.Upon this foundation,a web service integration of hospital information system based on SOA was realized.Results This design scheme realized the effective management and integration of huge information resources,and managed the medical workflow effectively.Conclusion This design scheme provides the regional cooperative healthcare system with the characteristics of modularization and expansibility.Hierarchy architecture enhances the stability of the system.

Research on integration of medical information system based on SOA / 医疗卫生装备

Objective To build an architecture for medical information integration based on SOA(Service-Oriented Architecture)by analyzing the characters of medical information integration and the integration technology of SOA. Methods Virtual database was built by XML Schema mapping for conform share of medical data based on XML technology. The method and principle of Web Services for medical information were researched and built. Results Medical information systems could uniformly exchange information based on standards of Web Services, and the conform medical information share mode was realized. Conclusion The integration of medical information systems based on SOA not only has the characteristics of loose-coupling and customization agility but also makes information share possible because of conform mode.