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Objective: To assess the effect and safety of Qilong Capsule (QLC) in treating apoplexy involving the meridians (Qi-deficiency and blood-stasis syndrome ). Methods: A randomized , do uble-blinded double-dummy controlled trial was adopted. One hundred and two pati ents were treated with QLC, 101 with Xiaoshuan oral liquid (XOL ) and 200 served as the open treatment group. Results: The total effective rate in QLC group was 89.22% and symptomatic relieved rate 44.12%,showing t hat QLC was more effective than XOL（P＜0.01）.Conc lusion: QLC is effective for apoplexy involving the meridians and has no side an d toxic effects.
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0.05) . NNS could decrease blood viscosity and hematocrit, inhibit the aggregation of erythrocytes and platelet and increase the activities of superoxide dismutase (SOD) and glutathione peroxidase (GSH -Px). [Conclusion] NNS has an effect on AIS, which is similar to nimodipine. Its therapeutic mechanism may be related to the relief of cerebral ischemia by improving blood rheology and cerebral blood flow and protecting brain cells from injury by eliminating free radicals.
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ive] To observe the therapeutic effect of Naoxing Granule (NG) for acute ischemic stroke (AIS) and to explore its mechanism. [Methods] Single-blind controlled trial was applied. Two hundred cases of AIS were randomly allocated to Group A (n = 150, treated with NG) and Group B (n = 50, treated with nimodipine). Therapeutic effect of NG was observed and plasma free radical levels and the ratio of thromboxane A2 (TXA2) and prostaglandin 2 (PGI2) were detected. [Results] The total effective rate was 91.3%and 76.0% , and the remarkably effective rate was 62.0% and 46.0% in Group A and Group B respectively ( P
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Yiqi Huoxue Oral Liquid(YHOL) was a formula with Qi Reinforcing and bind-circulationactivating actions consisting of Radix Astragali seu Hedysari,Heada,Radix Ilicis Pubesceatis,etc,To study its Pharmacological mechanism, the effects of YHOL on cerebral edema and ultra- struture of cereblal ischemic rat model after reperfusion were observed. The results showed that YHOLdecreased the water content of ischemic barn to some extent, alleviated the neurological symptoms andreduced the damage of brain ultrastructure in the early stage of reperfusion. It is indicated that YHOLcan reduce cereblal edema by protecting the fumction of vascular endothelial cell and the integrity of basicmembranes and improving microcirculation, and exerts a protective effect on the delayed death of neuron.This will Provide an experimental evidence for the clinical application of YHOL.
ABSTRACT
Naoxing oral preparation has ho formed to be effective for ischemic stroke by preliminary clin-ical trial. To find a safe, efficient and convenient preparation Naoxing nasal spray was developed. Theeffect of Naoxing nasal spray on increasing hypoxic toleance of brain cells and improving blood circulationwas confirmed in this experiment. Twenty-eight guinea Pigs were randomly allocated to 4 groups: Group A(Naoxing nasal spray),Group B (ninodipine injection intraperitoneally), GrouP C (ligushazine injectionintrqperitoneally) and Group D(distilled water for nasal spray). After the medication for 4 days, acutecerebral ischemia was produced by the occlusion of bilatelal caretid arteries for 45 minutes. Serum NO lev-el,superoxide dismutase(SOD), glutathione superoxidase (GSH--Px) and lipid peroxide (LPO) levelsin cerebral tissue were detected. Ultrastructure of right hippocampus was oberved.The results showedthat NO, SOD, GSH-Px level in Group A is significantly higher and LPO level is significantly lower thanthere in Group D(P0.05).The damage of neuron, gliocyte and capillary under electron microscope was less thanGroup D,the differences being not significant as compared with Group B and C. It is concluded that theeffect of Naoxing nasal splay is as ed as ninodipine and ligustazine injection.