Experimental study on pharmacodynamics of Su Bei Zhi Ke granules (SBZKG) for acute tracheobronchitis / 中国临床药理学与治疗学

AIM: To observe the effect of Su Bei Zhi Ke granules (SBZKG) on acute tracheobronchitis (Syndrome of Wind-cold Attacking Lung). METHODS: Mouse ear swelling experiment and mouse abdominal capillary permeability experiment was used to observe its anti-inflammatory effect. Cough test in mice induced by ammonia water, and phlegm test in rats were used to observe the expectorant and antitussive effects of phenol red test in mice. We used the mortality rate experiment of infected mice to observe its antibacterial and antiviral effects. RESULTS: Compared with the contral group, the large and medium dose groups of SBZKG both reduced mouse auricle swelling (P<0.05) and increased swelling inhibition rate, reducing mouse abdominal capillary permeability (P<0.05, P<0.01). SBZKG can increase the phenol red sputum output in the respiratory tract of mice (P<0.01), prolong the cough incubation period of mice, reduce the number of coughs in mice (P<0.05, P<0.01), and increase the sputum output in rats (P<0.05, P<0.01). SBZKG can reduce the mortality rate of mice infected with bacteria and viruses. CONCLUSION: SBZKG has certain anti-inflammatory, antitussive, expectorant, antibacterial and antiviral effects, and has certain therapeutic effects on acute tracheobronchitis.

Molecular mechanism of a Matijin-su derivative for inhibiting proliferation, invasion and migration of prostate cancer cells / 中国药理学通报

Aim To investigate the effects of HXL130 on the proliferation, invasion and migration of prostate cancer PC3 cells and its molecular mechanism. Methods MTT assay was used to detect the effect of HXL130 on the proliferation of prostate cancer PC3 cells. Hoechst 33258 staining and flow cytometry were used to detect the effects on apoptosis and cell cycle of cancer cells. Transwell was used to detect the effects of compounds on the invasion and migration of cancer cells. Proteomic sequencing was employed to detect differentially expressed proteins (DEPs) induced by compound treatment of cancer cells. Bioinformatics was used to analyze the functions of DEPs and the related signaling pathways regulated by DEPs, and Western blot was used to verify the result. Results The survival rate of PC3 cells decreased with the increase of HXL130 concentration and treatment time. HXL130 could significantly induce cell apoptosis and block G

The 10-year outcome and prognostic factors of laparoscopic D 2 radical distal gastrectomy for locally advanced gastric cancer: a CLASS multicenter study / 中华消化外科杂志

Objective:To investigate the 10-year outcome and prognostic factors of laparo-scopic D 2 radical distal gastrectomy for locally advanced gastric cancer. Methods:The retrospec-tive cohort study was conducted. The clinicopathological data of 652 patients with locally advanced gastric cancer who were admitted to 16 hospitals from the multicenter database of laparoscopic gastric cancer surgery in the Chinese Laparoscopic Gastrointestinal Surgery Study (CLASS) Group, including 214 cases in the First Affiliated Hospital of Army Medical University, 191 cases in Fujian Medical University Union Hospital, 52 cases in Nanfang Hospital of Southern Medical University, 49 cases in West China Hospital of Sichuan University, 43 cases in Xijing Hospital of Air Force Medical University, 25 cases in Jiangsu Province Hospital of Chinese Medicine, 14 cases in the First Medical Center of the Chinese PLA General Hospital, 12 cases in No.989 Hospital of PLA, 12 cases in the Third Affiliated Hospital of Sun Yat-Sen University, 10 cases in the First Affiliated Hospital of Nanchang University, 9 cases in the First People's Hospital of Foshan, 7 cases in Zhujiang Hospital of Southern Medical University, 7 cases in Fujian Medical University Cancer Hospital, 3 cases in Zhongshan Hospital of Fudan University, 2 cases in Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 2 cases in Peking University Cancer Hospital & Institute, from February 2004 to December 2010 were collected. There were 442 males and 210 females, aged (57±12)years. All patients underwent laparoscopic D 2 radical distal gastrectomy. Observation indicators: (1) surgical situations; (2) postoperative pathological examination; (3) postoperative recovery and complications; (4) follow-up; (5) prognostic factors analysis. Follow-up was conducted by outpatient examination and telephone interview to detect the tumor recurrence and metastasis, postoperative survival of patients up to March 2020. Measurement data with normal distribution were represented as Mean± SD, and measurement data with skewed distribution were represented as M( Q1, Q3) or M(range). Count data were described as absolute numbers or percen-tages, and comparison between groups was conducted using the chi-square test. Comparison of ordinal data was analyzed using the rank sum test. The life table method was used to calculate survival rates and the Kaplan-Meier method was used to draw survival curves. Log-Rank test was used for survival analysis. Univariate and multivariate analyses were analyzed using the COX hazard regression model. Results:(1) Surgical situations: among 652 patients, 617 cases underwent D 2 lymph node dissection and 35 cases underwent D 2+ lymph node dissection. There were 348 cases with Billroth Ⅱ anastomosis, 218 cases with Billroth Ⅰ anastomosis, 25 cases with Roux-en-Y anastomosis and 61 cases with other digestive tract reconstruction methods. Twelve patients had combined visceral resection. There were 569 patients with intraoperative blood transfusion and 83 cases without blood transfusion. The operation time of 652 patients was 187(155,240)minutes and volume of intraoperative blood loss was 100(50,150)mL. (2) Postoperative pathological examina-tion: the maximum diameter of tumor was (4.5±2.0)cm of 652 patients. The number of lymph node dissected of 652 patients was 26(19,35), in which the number of lymph node dissected was >15 of 570 cases and ≤15 of 82 cases. The number of metastatic lymph node was 4(1,9). The proximal tumor margin was (4.8±1.6)cm and the distal tumor margin was (4.5±1.5)cm. Among 652 patients, 255 cases were classified as Borrmann type Ⅰ-Ⅱ, 334 cases were classified as Borrmann type Ⅲ-Ⅳ, and 63 cases had missing Borrmann classification data. The degree of tumor differentiation was high or medium in 171 cases, low or undifferentiated in 430 cases, and the tumor differentiation data was missing in 51 cases. There were 123, 253 and 276 cases in pathological stage T2, T3 and T4a, respectively. There were 116, 131, 214 and 191 cases in pathological stage N0, N1, N2 and N3, respectively. There were 260 and 392 cases in pathological TNM stage Ⅱ and Ⅲ, respectively. (3) Postoperative recovery and complications: the time to postoperative first out-of-bed activities, time to postoperative first flatus, time to the initial liquid food intake, duration of postoperative hospital stay of 652 patients were 3(2,4)days, 4(3,5)days, 5(4,6)days, 10(9,13)days, respectively. Among 652 patients, 69 cases had postoperative complications. Clavien-Dindo grade Ⅰ-Ⅱ, grade Ⅲa, grade Ⅲb, and grade Ⅳa complications occurred in 60, 3, 5 and 1 cases, respectively (some patients could have multiple complications). The duodenal stump leakage was the most common surgical complication, with the incidence of 3.07%(20/652). Respiratory complication was the most common systemic complication, with the incidence of 2.91%(19/652). All the 69 patients were recovered and discharged successfully after treatment. (4) Follow-up: 652 patients were followed up for 110-193 months, with a median follow-up time of 124 months. There were 298 cases with postoperative recurrence and metastasis. Of the 255 patients with the time to postoperative recurrence and metastasis ≤5 years, there were 21 cases with distant metastasis, 69 cases with peritoneal metastasis, 37 cases with local recurrence, 52 cases with multiple recurrence and metastasis, 76 cases with recurrence and metastasis at other locations. The above indicators were 5, 9, 10, 4, 15 of the 43 patients with the time to postoperative recurrence and metastasis >5 years. There was no significant difference in the type of recurrence and metastasis between them ( χ2=5.52, P>0.05). Cases in pathological TNM stage Ⅱ and Ⅲ were 62 and 193 of the patients with the time to postoperative recurrence and metastasis ≤5 years, versus 23 and 20 of the patients with the time to postoperative recurrence and metastasis >5 years, showing a significant difference in pathological TNM staging between them ( χ2=15.36, P<0.05). Cases in pathological stage T2, T3, T4a were 42, 95, 118 of the patients with the time to postoperative recurrence and metastasis ≤5 years, versus 9, 21, 13 of the patients with the time to postoperative recurrence and metastasis >5 years, showing no significant difference in pathological T staging between them ( Z=-1.80, P>0.05). Further analysis showed no significant difference in cases in pathological stage T2 or T3 ( χ2=0.52, 2.08, P>0.05) but a significant difference in cases in pathological stage T4a between them ( χ2=3.84, P<0.05). Cases in pathological stage N0, N1, N2, N3 were 19, 44, 85, 107 of the patients with the time to postoperative recurrence and metastasis ≤5 years, versus 12, 5, 18, 8 of the patients with the time to postoperative recurrence and metastasis >5 years, showing a significant difference in pathological N staging between them ( Z=-3.34, P<0.05). Further analysis showed significant differences in cases in pathological stage N0 and N3 ( χ2=16.52, 8.47, P<0.05) but no significant difference in cases in pathological stage N1 or N2 ( χ2=0.85, 1.18, P>0.05). The median overall survival time was 81 months after surgery and 10-year overall survival rate was 46.1% of 652 patients. The 10-year overall survival rates of patients in TNM stage Ⅱ and Ⅲ were 59.6% and 37.5%, respectively, showing a significant difference between them ( χ2=35.29, P<0.05). In further analysis, the 10-year overall survival rates of patients in pathological TNM stage ⅡA, ⅡB, ⅢA, ⅢB and ⅢC were 65.6%, 55.8%, 46.9%, 37.1% and 24.0%, respectively, showing a significant difference between them ( χ2=55.06, P<0.05). The 10-year overall survival rates of patients in patholo-gical stage T2, T3 and T4a were 55.2%, 46.5% and 41.5%, respectively, showing a significant difference between them ( χ2=8.39, P<0.05). The 10-year overall survival rates of patients in patholo-gical stage N0, N1, N2 and N3 were 63.7%, 56.2%, 48.5% and 26.4%, respectively, showing a signifi-cant difference between them ( χ2=54.89, P<0.05). (5) Prognostic factors analysis: results of univariate analysis showed that age, maximum diameter of tumor, degree of tumor differentiation as low or undifferentiated, pathological TNM staging, pathological T staging, pathological stage N2 or N3, post-operative chemotherapy were related factors for the 10-year overall survival rate of locally advanced gastric cancer patients undergoing laparoscopic D 2 radical distal gastrectomy ( hazard ratio=1.45, 1.64, 1.37, 2.05, 1.30, 1.68, 3.08, 0.56, 95% confidence interval as 1.15-1.84, 1.32-2.03, 1.05-1.77, 1.62-2.59, 1.05-1.61, 1.17-2.42, 2.15-4.41, 0.44-0.70, P<0.05). Results of multivariate analysis showed that maximum diameter of tumor >4 cm, low-differentiated or undifferentiated tumor, pathological TNM stage Ⅲ were independent risk factors for the 10-year overall survival rate of locally advanced gastric cancer patients undergoing laparoscopic D 2 radical distal gastrectomy ( hazard ratio=1.48,1.44, 1.81, 95% confidence interval as 1.19-1.84, 1.11-1.88, 1.42-2.30, P<0.05) and postoperative chemotherapy was a independent protective factor for the 10-year overall survi-val rate of locally advanced gastric cancer patients undergoing laparoscopic D 2 radical distal gastrec-tomy ( hazard ratio=0.57, 95% confidence interval as 045-0.73, P<0.05). Conclusions:Laparoscopic assisted D 2 radical distal gastrectomy for locally advanced gastric cancer has satisfactory 10-year oncologic outcomes. A high proportion of patients in pathological TNM stage Ⅲ, pathological stage T4a, pathological stage N3 have the time to postoperative recurrence and metastasis ≤5 years, whereas a high proportion of patients in pathological TNM stage Ⅱ or pathological stage N0 have the time to postoperative recurrence and metastasis >5 years. Maximum diameter of tumor >4 cm, low-differentiated or undifferentiated tumor, pathological TNM stage Ⅲ are independent risk factors for the 10-year overall survival rate of locally advanced gastric cancer patients undergoing laparos-copic D 2 radical distal gastrectomy. Postoperative chemotherapy is a independent protective factor for the 10-year overall survival rate of locally advanced gastric cancer patients undergoing laparos-copic D 2 radical distal gastrectomy.

Bases teóricas sobre la evaluación de la calidad del servicio en salud / Theoretical bases on health service quality assessment

Exponer las diferentes conceptualizaciones y los modelos de evaluación de la calidad de servicio en salud, respecto a sus características, fundamentos, y diferencias a través del análisis y síntesis de los aspectos más significativos encontrados en la literatura. Se realizó una revisión bibliográfica, bajo el sustento teórico de los siguientes métodos teóricos: Análisis, síntesis, histórico lógico y análisis documental de 19 artículos completos, accesibles en el idioma español e inglés, recolectados de bases de datos académicos como Google Académico, Research Gate, PubMed, Cochrane Library, Scielo Salud pública. Destacar que la búsqueda, recolección y análisis se realizó en los meses de mayo a julio. Tras la revisión bibliográfica pone en manifiesto la falta de consenso entre los expertos en el tema de calidad respecto a su conceptualización, misma que ha evolucionado conforme al contexto, social, tecnológico y científico. En definitiva, las bases teóricas para la evaluación de la calidad de atención en el servicio de salud, el primer modelo específico aplicado a salud fue el modelo de Abedis Donabedian, continuando las bases teóricas con el paradigma de la desconfirmación liderada por el modelo nórdico de Grönroos, el modelo de Parasumaran, Berry y Zeithaml respecto a la brecha que existe entre las expectativas y percepción; y el modelo de Cronin Taylor respecto a la valoración de las percepciones. Así mismo, se concluye, que el constructo de calidad está en evolución y su interpretación depende del observador y sus prioridades en base a la adaptación del instrumento respecto al contexto de aplicabilidad.

To expose the different conceptualizations and models of health service quality evaluation, regarding their characteristics, foundations, extension and differences through the analysis and synthesis of the most significant aspects found in the literature. A bibliographic review was carried out under the theoretical support of the following theoretical methods: analysis, synthesis, logical history and documentary analysis of 18 complete articles, accessible in Spanish and English, collected from academic databases such as Google Scholar, Research Gate, PubMed, Cochrane Library, Scielo Public Health, the search, collection and analysis was carried out from May to July. The bibliographic review reveals the lack of consensus among experts on the subject of quality with respect to its conceptualization, which has evolved according to the social, technological and scientific context. In short, the theoretical bases for the evaluation of the quality of care in the health service, the first specific model applied to health was the Abedis Donabedian model, continuing the theoretical bases with the paradigm of disconfirmation led by the Nordic model of Grönroos, the model of Parasumaran, Berry and Zeithaml regarding the gap that exists between expectations and perception; and the Cronin Taylor model regarding the assessment of perceptions. It is also concluded that the quality construct is evolving and its interpretation depends on the observer and his or her priorities based on the adaptation of the instrument to the context of applicability

Alcance del derecho a la estabilidad reforzada en Colombia: Sentencia SU-049 de 2017 / Scope of the Right to Reinforced Stability in Colombia: Sentence ITS-049, 2017 / Alcance do direito à estabilidade reforçada na Colômbia: Sentença SU-049 de 2017

RESUMEN Se describen los argumentos a partir de los cuales los magistrados de la Corte Constitucional colombiana respaldaron la solución al problema sobre si la estabilidad reforzada se circunscribe a personas calificadas con pérdida de capacidad laboral, e incorporadas al mundo del trabajo mediante contrato laboral; se muestran los argumentos desde los cuales los magistrados de la Corte justificaron su respuesta al asunto sobre si la vulneración a la estabilidad reforzada conlleva la aplicación de las prestaciones fijadas en la Ley 361 de 1997 aún en un contexto de prestación de servicio y sin que el trabajador posea calificación de pérdida de la capacidad laboral; y se concluye que en la sentencia SU-049 de 2017 dichos magistrados actualizaron el alcance del derecho a la estabilidad reforzada acorde con principios constitucionales de igualdad, solidaridad, dignidad y protección de las diferentes modalidades de trabajo, concediendo indemnización de 180 días de salario y reintegro del trabajador sin importar la tenencia del certificado de calificación de pérdida de capacidad laboral ni la forma de vinculación contractual. El enfoque metodológico acogido es hermenéutico.

ABSTRACT Describes arguments on which the magistrates of the Colombian Constitutional Court endorsed the solution to the problem are described as to whether the reinforced stability is limited to qualified people with loss of work capacity and incorporated into the world of work through an employment contract; The arguments from which the judges of the Court justified their response to the matter are shown on whether the violation of the enhanced stability entails the application of the benefits fixed for in Law 361 of 1997 even in a context of service provision and without worker has a qualification of loss of work capacity; and it is concluded that in judgment SU-049 of 2017, said magistrates updated the scope of the right to enhanced stability in accordance with constitutional principles of equality solidarity dignity and protection of the different types of work, granting compensation of 180 days of salary and Reinstatement of the worker regardless of the possession of the qualification certificate of loss of work capacity or the form of contractual relationship. The accepted methodological approach is hermeneutical.

RESUMO Descrevem-se os argumentos com base nos quais os magistrados do Tribunal Constitucional colombiano endossaram a solução do problema, se a estabilidade reforçada se limita a pessoas qualificadas com perda de capacidade laboral e se incorpora ao mundo do trabalho por meio de um contrato; apresentam-se os argumentos com os quais os magistrados do Tribunal justificaram a sua resposta à questão sobre se a violação da estabilidade reforçada implica a aplicação dos benefícios previstos na Lei 361 de 1997, mesmo em contexto de prestação de serviço e sem a trabalhador tem qualificação de perda de capacidade de trabalho; e conclui-se que na sentença SU-049 de 2017, os referidos magistrados atualizaram o âmbito do direito à estabilidade reforçada de acordo com os princípios constitucionais da igualdade, solidariedade, dignidade e proteção dos diversos tipos de trabalho, concedendo indemnização de 180 dias de vencimento e Reintegração do trabalhador independentemente da posse do certificado de habilitação de perda da capacidade de trabalho ou da forma de relação contratual. A abordagem metodológica aceita é hermenêutica.

Calidad del aire en la ciudad San Francisco de Milagro y su influencia en la salud poblacional / Air quality in the city of San Francisco de Milagros and its influence on population health

atmosférica es responsable de 6.67 millones de muertes al año por accidentes cardiovasculares, enfermedades cardíacas, cáncer de pulmón y enfermedades respiratorias crónicas (HEI, 2020; OMS, 2021). La presente investigación determino la calidad del aire en la ciudad San Francisco de Milagro y su influencia en la salud poblacional. Los esultados expresan, que la concentración promedio de estos gases están dentro delos estándares establecidos por la OMS (2005), OMS (2018); para cada uno de ellos y por ende no son dañinos para la salud de la población en esudio. Sin embargo, actividades de desarrollo local como el caso de obras de construcción, estarían causando molestias en la población, debido a la falta de control y regulación ambiental, como lo demostró el estudio de percepciones(AU)

Environmental pollution is a global health problem with serious negative implications for humans. According to the WHO, air pollution is responsible for 6.67 million deaths per year from cardiovascular accidents, heart disease, lung cancer and chronic respiratory diseases (HEI, 2020; WHO, 2021). This research determined the air quality in the city of San Francisco de Milagro and its influence on population health. The results express that the average concentration of these gases are within the standards established by the WHO (2005), WHO (2018); for each of them and therefore are not harmful to the health of the population under study. However, local development activities such as construction works would be causing inconvenience to the population, due to the lack of environmental control and regulation, as the perceptions study showed(AU)

The mechanism of Suzi-Jiangqi Decoction in treatment of COPD based on network pharmacology / 国际中医中药杂志

Objective:By using the network pharmacology method to predict the active constituents and action targets of Suzi-Jiangqi Decoction in the treatment of COPD, and to explore its potential molecular mechanism with multi-component, multi-target and multi-pathway characteristics. Methods:The active constituents and targets of Suzi-Jiangqi Decoction were collected, screened and predicted according to the Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform (TCMSP) and UniProt software. Search for the gene targets related to COPD in GeneCards, online human Mendelian genetic database (OMIM) and TTD database. The intersection targets of component targets and disease targets were obtained by Veen map online software. The network model with the sequence of active constituents-target-disease was constructed and analyzed by Cytoscape software, and the protein-protein interaction network (PPI) was constructed by STRING database. The gene ontology function annotation (GO) and Tokyo genome encyclopedia (KEGG) pathway enrichment analysis of common targets with metascape online tool. Results:A total of 163 active constituents of Suzi-Jiangqi Decoction were screened, 283 targets were predicted, and 159 targets involved in the treatment of COPD. Quercetin, kaempferol, naringin and luteolin were the key active ingredients. IL6, TNF, MAPK3, JUN, CASP3, CXCL8, CXCL10, MMP9 and MAPK1 were important gene targets. GO analysis showed that the biological processes involved in the enrichment of key gene targets included the response to bacteria, the cytokine mediated signaling pathway, the cell's response to inorganic substances, the response to oxidative stress, the response to LPS, and so on. The enrichment analysis of KEGG pathway showed that the signaling pathway of Suzi-Jiangqi Decoction in the treatment of COPD included TNF signaling pathway, IL-17 signaling pathway, cell cycle, Influenza A, HTLV-I infection, AGE-RAGE signaling pathway, Tuberculosis, Epstein-Barr virus infection and so on. Conclusion:Suzi-Jiangqi Decoction can treat COPD through multi-target and multi-pathway mechanisms of anti-inflammatory, anti infection and immune regulation, which lays a foundation for further study of its molecular mechanism.

The mechanism of enriched environment repairing the learning and memory impairment in offspring of prenatal stress by regulating the expression of activity-regulated cytoskeletal-associated and insulin-like growth factor-2 in hippocampus

BACKGROUND@#Prenatal stress can cause neurobiological and behavioral defects in offspring; environmental factors play a crucial role in regulating the development of brain and behavioral; this study was designed to test and verify whether an enriched environment can repair learning and memory impairment in offspring rats induced by prenatal stress and to explore its mechanism involving the expression of insulin-like growth factor-2 (IGF-2) and activity-regulated cytoskeletal-associated protein (Arc) in the hippocampus of the offspring.@*METHODS@#Rats were selected to establish a chronic unpredictable mild stress (CUMS) model during pregnancy. Offspring were weaned on 21st day and housed under either standard or an enriched environment. The learning and memory ability were tested using Morris water maze and Y-maze. The expression of IGF-2 and Arc mRNA and protein were respectively measured by using RT-PCR and Western blotting.@*RESULTS@#There was an elevation in the plasma corticosterone level of rat model of maternal chronic stress during pregnancy. Maternal stress's offspring exposed to an enriched environment could decrease their plasma corticosterone level and improve their weight. The offspring of maternal stress during pregnancy exhibited abnormalities in Morris water maze and Y-maze, which were improved in an enriched environment. The expression of IGF-2, Arc mRNA, and protein in offspring of maternal stress during pregnancy was boosted and some relationships existed between these parameters after being exposed enriched environment.@*CONCLUSIONS@#The learning and memory impairment in offspring of prenatal stress can be rectified by the enriched environment, the mechanism of which is related to the decreasing plasma corticosterone and increasing hippocampal IGF-2 and Arc of offspring rats following maternal chronic stress during pregnancy.

Processo de trabalho da equipe de enfermagem em Centros de Atenção Psicossocial Infanto-Juvenil / Proceso de trabajo del equipo de enfermería en Centros de Acompañamiento Psicosocial Infantil y Juvenil / The nursing team work process in Children and Adolescents Psychosocial Care Centers

RESUMO Objetivo Conhecer o processo de trabalho da equipe de enfermagem em Centros de Atenção Psicossocial Infanto-Juvenil de um município do estado de São Paulo. Método Estudo qualitativo, descritivo e exploratório, embasado na abordagem do materialismo histórico e dialético, realizado com a equipe de enfermagem por meio de observação participante e entrevistas semiestruturadas. Resultados Participaram 11 sujeitos da equipe de enfermagem. O processo de trabalho da equipe de enfermagem emerge da tensão dialética de duas categorias: o não saber, pautado na alienação do processo de trabalho de enfermagem e na subordinação ao saber da equipe multiprofissional, e o saber pautado na clínica de enfermagem delineada entre as perspectivas biológica e relacional. Conclusão O processo de trabalho da equipe de enfermagem acontece quando pautado em um não saber pela alienação ao saber do outro, e em um saber por meio da implementação do Processo de Enfermagem pela Sistematização da Assistência de Enfermagem na perspectiva biológica, considerando aspectos relacionais e administrativos, o que se configura como uma contradição.

RESUMEN Objetivo: Conocer el proceso de trabajo del equipo de enfermería en Centros de Acompañamiento Psicosocial Infantil y Juvenil de un municipio de la provincia de São Paulo. Método: Estudio cualitativo; descriptivo y exploratorio; basado en el abordaje del materialismo histórico y dialéctico; realizado con el equipo de enfermería por medio de observación participante y entrevistas semiestructuradas. Resultados: Participaron 11 miembros del equipo de enfermería. Su proceso de trabajo surge de la tensión dialéctica de dos clases: el no saber; basado en la alienación del proceso de trabajo de enfermería y la subordinación al saber del equipo multiprofesional; y al saber basado en la clínica de enfermería diseñada entre la perspectiva biológica y relacional. Conclusión: El proceso de trabajo del equipo de enfermería ocurre cuando basado en un "no saber" por la alienación al saber de uno; y en un saber a través de la implementación del Proceso de Enfermería por la Sistematización del Acompañamiento de Enfermería en la perspectiva biológica; considerando aspectos de relación y administración; lo que se define como una contradicción

ABSTRACT Objective To know the nursing team work process in Children and Adolescents Psychosocial Care Centers in a city of the state of São Paulo. Method This is a qualitative, descriptive, and exploratory study, based on the approach of historical and dialectical materialism, carried out with the nursing team through participant observation and semi-structured interviews. Results Eleven subjects from the nursing team participated in the study. The nursing team work process emerges from the dialectical tension of two categories: the non-knowledge, based on the alienation of the nursing work process and subordination to the knowledge of the multidisciplinary team, and the knowledge based on the nursing clinic outlined within the biological and relational perspectives. Conclusion The nursing team work process takes place when guided by a non-knowledge resulting from alienation due to the knowledge of the other, and by knowledge through the implementation of the Nursing Process through the Nursing Care Systematization based on a biological perspective, considering relational and administrative aspects, which emerges as a contradiction.

Alteraciones en el sueño por el consumo de cannabis / Sleep disturbances from the use of cannabis

RESUMEN Esta es una revisión de algunos ensayos clínicos realizados acerca de las repercusiones en la estructura, arquitectura y percepción del sueño en los consumidores de cannabis. Para la búsqueda bibliográfica se consultó bases de datos, con especial énfasis en revisiones sistemáticas, metaanálisis, estudios de cohortes, ensayos controlados aleatorios y estudios de casos y controles. Las palabras claves incluyeron términos que describen el uso del cannabis combinado con otros que se refieren al sueño o anormalidades del sueño (por ejemplo: sueño, insomnio, polisomnografía, tiempo total de sueño, latencia del sueño, sueño de onda lenta, sueño de movimiento ocular rápido y su latencia). Se extrajeron datos relevantes de cada uno de los artículos consultados. Se resumió la literatura disponible sobre mediciones subjetivas y objetivas, correlaciones clínicas y paraclínicas, diferencias entre el consumo agudo, crónico y la abstinencia, y otros puntos de discusión. Se realizaron varias correlaciones moleculares y anatómicas que explican los cambios en el sueño desde el punto de vista del sistema nervioso central. Finalmente, los resultados demuestran una disminución de la latencia del sueño con el uso agudo a dosis bajas, además menor tiempo de vigilia luego del inicio del sueño, aumento del sueño de ondas lentas y disminución del sueño de movimientos oculares rápidos; estos efectos no permanecen con el uso crónico, ya que posteriormente se presenta una peor calidad del sueño; el escenario también varía con la abstinencia, puede presentarse insomnio, disminución del tiempo total del sueño de onda lenta y del sueño total.

ABSTRACT This is a review of some clinical trials conducted on the impact on sleep structure, architecture and perception in cannabis users. For the literature search, consult database queries with special emphasis on systematic reviews, meta-analyzes, cohort studies, randomized controlled trials, and case-control studies. Keywords include terms that describe cannabis use combined with others that specify sleep or sleep abnormalities (for example: sleep, insomnia, polysomnography, total sleep time, sleep latency, slow wave sleep, motion sleep fast eyepiece and its latency). Relevant data was extracted in each of the articles consulted. The available literature is summarized on: subjective and objective measurements, clinical and paraclinical correlations, differences between acute and chronic consumption and abstinence, and other points of discussion. Tese are various molecular and anatomical correlations that explain changes in sleep from the point of view of the central nervous system. Finally, results frequently decrease sleep latency with acute use at low doses, plus shorter waking time after sleep onset, increased slow wave sleep and decreased rapid eye movement sleep, these effects do not persist with chronic use since later there is a worse quality of sleep; The setting also changes with abstinence where insomnia may occur, decreased total time for slow wave sleep and total sleep.

Consideraciones hipotéticas sobre el comportamiento viral del SARS-Cov-2 (covid-19): enfermedad multisistémica / Hypothetical considerations on the viral behavior of SARS-Cov-2 (covid-19): multisystemic disease

El virus provoca una reacción vascular inflamatoria en el endotelio arterial de varios órganos, entre ellos el pulmón (afectando el intercambio de gases en la membrana alveolo-capilar), de ahí la insuficiencia respiratoria, pero también afecta a otros órganos. Cuando una persona adquiere el nuevo coronavirus, este entra a los pulmones e infecta directamente a los alvéolos, que absorben el aire que respiramos. En casos graves, esos sacos de aire se llenan de líquido, restándole espacio para el oxígeno. Esto es lo que se conoce como neumonía por covid-19. Los alvéolos se infectan y activan el sistema inmunitario, lo que puede conducir a una tormenta de citoquinas. El SARS-Cov-2 también causa coágulos de sangre, lo que ha provocado que personas de entre 30 y 40 años mueran por accidentes cerebrovasculares. La enfermedad inflama los vasos sanguíneos y eventualmente puede dañar las arterias coronarias que llevan sangre al corazón. Entonces, cabe preguntarse: ¿no será que, además de afectar la membrana alvéolo-capilar en el pulmón, e interferir en el intercambio de oxígeno, afecta el endotelio arterial y provoca una microangiopatía diseminada con coagulopatía? Ojalá se encuentre pronto la respuesta. Miles de los mejores científicos del mundo están trabajando para intentar comprender el nuevo coronavirus; han descifrado su código genético y producido decenas de artículos que proponen posibles tratamientos y vacunas. Recomiendo un interesante artículo publicado por los Dres. Alfonso Papa y Giustino Varrassi, que creo que coincide con mi opinión sobre la afectación vascular en el SARS-Cov-2 (covid-19),1 disponible en: https://www.researchgate.net/publication/341553008. (AU)

The virus causes an inflammatory vascular reaction in the arterial endothelium of various organs, including the lung (affecting gas exchange in the alveolar-capillary membrane), hence the respiratory failure, but it also affects other organs. When a person acquires the new coronavirus, it enters to the lungs and directly infects the alveoli, which absorb the air we breathe. In severe cases, these air sacs fill with fluid, taking up space for oxygen. It is known as covid-19 pneumonia. The alveoli become infected and activate the immune system and can lead to a cytokine storm. SARS-Cov-2 also causes blood clots, which has caused people in their 30s to 40s to die from strokes. The disease inflames the blood vessels and can eventually damage the coronary arteries that carry blood to the heart. So, it is worth asking: Is it not that, in addition to affecting the alveolar-capillary membrane in the lung, and interfering with oxygen exchange, it affects the arterial endothelium and causes disseminated micro-angiopathy with coagulopathy? Hopefully the answers will be found soon. Thousands of the world's best scientists are working to try to understand the new coronavirus. They cracked their genetic code and have produced dozens of articles suggesting possible treatments and vaccines. I add an interesting article published by Drs. Alfonso Papa and Giustino Varrassi. I think it matches my opinion about vascular involvement in SARS-Cov-2 (covid-19),1 available at: https://www.researchgate.net/publication/341553008. (AU)

The association between genetic polymorphism of glutathione peroxidase 1 (rs1050450) and keratoconus in a Turkish population / A associação entre o polimorfismo genético da glutationa-peroxidase 1 (rs1050450) e pacientes com ceratocone em uma população turca

ABSTRACT Purpose: To investigate the potential associations between keratoconus and catalase rs1001179, superoxide dismutase 2 rs4880, and glutathione peroxidase 1 rs1050450 gene polymorphisms in a Turkish population. Methods: The study group included 121 unrelated keratoconus patients and 94 unrelated healthy controls. Blood samples (200 ml) were collected from all patients and controls to isolate genomic DNA. Genotyping was performed to identify rs1001179, rs4880, and rs1050450 using real-time polymerase chain reaction (PCR). Genotype and allele frequencies were calculated; their associations with keratoconus risk were assayed, and the association with keratoconus risk and demographic factors was examined. Results: Glutathione peroxidase 1 rs1050450 polymorphism was present in 41% cases compared with 29% controls (OR=1.66; 95% CI=1.11-2.50; p=0.014). No association was observed between catalase rs1001179 and SOD2 rs4880 polymorphisms and keratoconus (for all, p>0.05). Conclusions: This study evaluated possible relationships between rs1050450, rs1001179, and rs4880 polymorphisms and keratoconus susceptibility. We found a possible association between glutathione peroxidase 1 rs1050450 polymorphism and an increased risk of keratoconus. However, the genotype and allele frequencies were identical in the catalase rs1001179 and superoxide dismutase 2 rs4880 polymorphisms. Further studies are needed to analyze the effect of such variations in identifying keratoconus susceptibility.

RESUMO Objetivo: Investigar as possíveis associações entre o ceratocone e os polimorfismos rs1001179 da catalase, rs4880 da superóxido-dismutase 2 e rs1050450 da glutationa-peroxidase 1 rs1050450 em uma população turca. Métodos: O grupo de estudo incluiu 121 pacientes com ceratocone não relacionados e 94 controles saudáveis também sem pa rentesco. Amostra de sangue (200 mL) foram coletadas de todos os pacientes e controle para isolar o DNA genômico. A genotipagem foi realizada para identificar rs1001179, rs4880 e rs1050450 utilizando a reação em cadeia da polimerase (PCR) em tempo real. As frequências de genótipos e alelos foram calculadas, suas associações com o risco de ceratocone foram avaliadas, e a associação com risco de ceratocone e fatores demográficos foi examinada. Resultados: O polimorfismo da glutationa-peroxidase 1 rs1050450 estava presente em 41% dos casos, comparado com 29% dos controles (OR=1,66, IC 95%=1,11-2,50; p=0,014). Não foi observada associação entre o ceratocone e os polimorfismos rs1001179 e SOD2 rs4880 da catalase (para todos, p>0,05). Conclusões: Este estudo avaliou possíveis relações entre os polimorfismos rs1001179, rs4880 e suscetibilidade a cerato cone. Encontramos uma possível associação entre po limorfis mo da glutationa-peroxidase 1 rs1050450 e um risco aumentado de ceratocone. No entanto, o genótipo e as frequências alélicas foram idênticas nos polimorfismos rs1001179 da catalase e superóxido-dismutase 2 rs4880. Mais estudos são necessários para esclarecer o efeito dessas va riações na detecção da sus cetibilidade ao ceratocone.

Dedicated to scientific research and public service: in memory of Su The Lung, a master of preventive medicine in China / 中华疾病控制杂志

Su Teh Lung(1906-1985), a famous public health scientist, medical educator and thinker, one of the founders of epidemiology in China. Through scientific experiments and field investigations, he first clarified the distribution law of Oncomelania hupensis comprehensively and proposed the method of eliminating Oncomelania hupensis, and his work has made outstanding contributions to the study of the causes and prevention of schistosomiasis in China. He advocated a comprehensive research of every link of epidemiological process with ecological research, attached importance to statistical methods and logical thinking, went deep into the field, combined with reality, and created theoretical system of epidemiology in China. He advocated truth, seek truth from facts, devoted all his life to the practice and research of epidemic prevention and control, which has a far-reaching impact on the development of preventive medicine in China and the world.

Effects of cinobufacin on proliferation and expression of p-PTEN in breast cancer MDA-MB-231 and MCF-7 cells / 国际中医中药杂志

Objective@#To observe the effect of cinobufacin on the expression of phosphorylated PTEN protein in human breast cancer MCF-7 and MDA-MB-231 cells.@*Methods@#The MCF-7 and MDA-MB-231 cells were divided into control group, high dose group and low dose group according to random number table method. Low and high dose groups were added with 0.5, 5.0 mg/ml cinobufacin, 100 μl/well for intervention, respectively, while the control group was added with equal volume of RPMI-1640 medium. Cell Counting Kit-8 was used to detect cell proliferation assay at 24, 48, and 72 h following intervention. Immunoblotting was used to detect the expression of AKT/mTOR pathway protein expression and p-PTEN.@*Results@#At 24, 48, and 72 h after intervention, the proliferation of MCF-7 and MDA-MB-231 cells in high dose group were significantly decreased (P<0.05). Compared with the control group, the expression of p-AKT (MCF-7: 0.357 ± 0.064, 0.215 ± 0.056 vs. 0.924 ± 0.085; MDA-MB-231: 0.310 ± 0.022, 0.194 ± 0.019 vs. 0.811 ± 0.089), p-mTOR (MCF-7: 0.476 ± 0.039, 0.217 ± 0.038 vs. 0.838 ± 0.058; MDA-MB-231: 0.300 ± 0.031, 0.223 ± 0.025 vs. 0.896 ± 0.096), p-S6 (MCF-7: 0.551 ± 0.068, 0.428 ± 0.041 vs. 1.254 ± 0.264; MDA-MB-231: 0.281 ± 0.014, 0.197 ± 0.012 vs. 0.748 ± 0.022), p-PTEN (MCF-7: 0.487 ± 0.170, 0.184 ± 0.135 vs. 1.003 ± 0.284, P<0.05; MDA-MB-231: 0.261 ± 0.184, 0.170 ± 0.105 vs. 1.014 ± 0.206) in the low and high dose group significantly decreased (P<0.05).@*Conclusions@#Cinobufacin inhibited the proliferation of MCF-7 and MDA-MB-231 cells, which may be mediated by down-regulation of the expression of the upstream of the AKT/mTOR signaling pathway p-PTEN.

Choe Han-gi's Discourse on Singi and His Criticism on Chinese Medicine and Western Medicine: Focusing on the Relationship with Seo Gyeong-deok's Philosophy / 의사학

This study examines how Choe Han-gi (崔漢綺, 1803–1879) developed his medical discourse which integrated the concepts of traditional Chinese medicine with modern Western anatomy, based on the philosophy of Seo Gyeong-deok (徐敬德, 1489–1546), a scholar of the Neo-Confucianism of Joseon (1392–1910). Seo emphasized gi (氣, C. qi, vital, material force) rather than yi (理, C. li, the principle of things) as a way of understanding the world. Since Choe's early academic interests pertained to Neo-Confucianism, it is reasonable to examine his philosophy in this context. Similar to Seo, Choe assumed that the most essential component of the world was the intrinsic and mysterious gi. Although Seo spoke of gi as a damil cheongheo ji gi (湛一淸虛之氣, the gi which is profound, uniform, clear, invisible, and empty), Choe preferred to use the word singi (神氣, C. shenqi, the intrinsic, invisible, and mysterious gi). He believed that the earth, moon, and stars operated through the action of singi and that all creatures could only exist by relying on it. Singi was the most important premise in Choe's medical discourse, a fact demonstrating that although he could be very critical of traditional Chinese medicine, his perspective was part of that tradition. He believed that singi integrated and operated the entire human body and that it perceived external objects. He also emphasized the role of hyeongjil (形質, C. xingzhi, a visible object with a form and quality; here it means all human bodies). This was the medium through which singi could appear in reality. Choe thought that singi could not reveal itself in reality without hyeongjil, and that hyeongjil became a dead thing without singi. His perception of the role of hyeongjil was expressed in his interest in modern Western anatomy, an interest that complemented his focus on singi. In light of his understanding of the singi-hyeongjil relationship, Choe criticized both modern Western anatomy and traditional Chinese medicine. He thought that modern Western anatomy lacked awareness of singi and that traditional Chinese medicine lacked accurate knowledge of human anatomy. Although he was not completely sympathetic toward any forms of medicine, he was open to ideas from both Western and Chinese medicine. Choe could not accept Western anatomy as fully as Japanese intellectuals did. The study of anatomy in Japan had developed in relation to the idea of Ancient Learning (古學, C. guxue), which denied such theories of systematic correspondence as Yin and Yang and the Five Elements (陰陽 五行, C. yinyang wuxing) and tended to focus on the action of hyeongjil itself. Because Choe accepted modern Western anatomy without accepting Ancient Learning, his perspective was unique in the history of East Asian anatomy. From a medical history perspective, how does Choi Han-gi's medical discourse distinguish itself from other medical discourses, and what are its characteristics? In addition to other explanations, focusing on the political imagination associated with medicine can help illuminate the differences between the medical discourse of Choe and those of others. Discussion of medicine and the human body was tied to political thought, manifesting the political imagination of the society in which that discussion took place. The development of Western and Japanese anatomy reflected a vertical and hierarchical political order, exemplified by the belief that the brain was the center of the body. However, Choe doubted that organs like the brain or heart dominated the body. In his view, the singi ruled the body; it was not a specific organ, and it was equally inherent in all people. His political thought also emphasized the horizontal and equal order among people. His view of singi simultaneously influenced both his perspective on medicine and his perspective on society. Choe Han-gi's belief in this horizontal and equal political order was inherent in his singi-centered medical discourse.

Synthesis and Anti-HBV Activity Evaluation of Matijin-Su Derivatives Containing Trifluoromethyl / 中国药学杂志

OBJECTIVE: To design and synthesize derivatives of Matijin-Su (MTS) containing trifluoromethyl group and investigate their anti-HBV activities in vitro. METHODS: Taking MTS as lead compound, target compounds were prepared by acylation, alkylation and hydrolysis, etc. The cytotoxicities and anti-HBV activities of the target compounds were tested with MTT method.RESULTS Twenty derivatives of MTS containing trifluoromethyl were synthesized and their structures were confirmed by 1H-NMR, 13C-NMR and MS(ESI). The anti-HBV activities of those compounds were evaluated in HepG2 2.2.15 cells. The screening RESULTS: showed that compounds 3b, 6a, 6c, 6d, 6h-6j and 6n had HBV inhibitory effect for HepG2 2.2.15 cells. Compounds 3b, 6d and 6n exhibited significant anti-HBV activity with IC50 values of 11.74, 8.73 and 11.41 μmol•L-1. CONCLUSION: Incorporation of trifluoromethyl into MTS derivatives can lead to profound changes in their anti-HBV activity, and could be worth of further research.

Effects of cinobufacin on proliferation and expression of p-PTEN in breast cancer MDA-MB-231 and MCF-7 cells / 国际中医中药杂志

Objective To observe the effect of cinobufacin on the expression of phosphorylated PTEN protein in human breast cancer MCF-7 and MDA-MB-231 cells. Methods The MCF-7 and MDA-MB-231 cells were divided into control group, high dose group and low dose group according to random number table method. Low and high dose groups were added with 0.5, 5.0 mg/ml cinobufacin, 100 μl/well for intervention, respectively, while the control group was added with equal volume of RPMI-1640 medium. Cell Counting Kit-8 was used to detect cell proliferation assay at 24, 48, and 72 h following intervention. Immunoblotting was used to detect the expression of AKT/mTOR pathway protein expression and p-PTEN. Results At 24, 48, and 72 h after intervention, the proliferation of MCF-7 and MDA-MB-231 cells in high dose group were significantly decreased (P<0.05). Compared with the control group, the expression of p-AKT (MCF-7: 0.357 ± 0.064, 0.215 ± 0.056 vs. 0.924 ± 0.085; MDA-MB-231: 0.310 ± 0.022, 0.194 ± 0.019 vs. 0.811 ± 0.089), p-mTOR (MCF-7:0.476 ±0.039, 0.217 ±0.038 vs. 0.838 ±0.058; MDA-MB-231: 0.300 ±0.031, 0.223 ±0.025 vs. 0.896 ±0.096), p-S6 (MCF-7: 0.551 ±0.068, 0.428 ±0.041 vs. 1.254 ±0.264; MDA-MB-231: 0.281 ±0.014, 0.197 ±0.012 vs. 0.748 ±0.022), p-PTEN (MCF-7: 0.487 ±0.170, 0.184 ±0.135 vs. 1.003 ±0.284, P<0.05; MDA-MB-231: 0.261 ± 0.184, 0.170 ± 0.105 vs. 1.014 ± 0.206) in the low and high dose group significantly decreased (P<0.05). Conclusions Cinobufacin inhibited the proliferation of MCF-7 and MDA-MB-231 cells, which may be mediated by down-regulation of the expression of the upstream of the AKT/mTOR signaling pathway p-PTEN.

Método metcoff y peso para edad gestacional por capurro como factores pronósticos de morbilidad y mortalidad durante el periodo neonatal precoz en recién nacidos a término parto vaginal / Metcoff method and weight for gestational age by capurro as prognostic factors of morbility and mortality during the neonatal period previous in newborns at term vaginal birth

Objetivo: Comparar método METCOFF y peso para su edad gestacional por Capurro como factores pronóstico de morbimortalidad durante periodo neonatal precoz en recién nacido a término. Material y métodos: estudio analítico prospectivo tipo cohorte. La población fue todos recién nacidos a término por parto único vaginal. La muestra se calculó con Epidat 3.1, usando una razón de no expuestos sobre expuestos para sospecha de sepsis neonatal de 20% en evaluados con la escala CANSCORE; nivel de confianza de 95% y potencia mínima de 70%, se obtuvo 49 recién nacidos a término con malnutrición fetal y 245 recién nacidos sin malnutrición fetal. Resultados: recién nacidos con malnutrición fetal fueron 46 (15,6%) y 248 (84,4%) sin malnutrición fetal, de los cuales 32 (69,6%) y 53 (21,4%) presentaron alguna morbilidad respectivamente. Según la clasificación de peso para la edad gestacional, 239 (81,3%) fueron AEG, 46(15,6%) GEG y 9(3,1%) PEG, presentaron malnutrición fetal con el método METCOFF, 5 (55,6%), 40 (16,7%) y 1 (2,2%) de los recién nacidos PEG, AEG y GEG respectivamente. Los recién nacidos expuestos a malnutrición fetal presentaron un riesgo de 4,18 y 3,34 veces mayor para desarrollar morbilidad y policitemia respectivamente que los recién nacidos sin malnutrición fetal (p<0,05); las curvas de Kaplan Meier muestran significancia (Log Rank < 0,05) estadística para sobrevida libre de morbilidad con método METCOFF, todo lo contrario para peso para EG. Conclusión: El método de evaluación nutricional METCOFF tienen mejor valor pronóstico para morbilidad que el peso para edad gestacional.

Atenção Básica em Produção: Tessituras do Apoio na Gestão Estadual do SUS / Basic Care in Production: Textures of Support in SUS State Management

A produção de autoria é um dos desafios da gestão pública e está na dependência de múltiplos vetores simultâneos. Elementos mesclados e sinérgicos que incluem os trabalhadores implicados em seus fazeres, o ambiente institucional cujas práticas cotidianas propiciam aprendizagem e constituem coletivos que decidem dar visibilidade a suas experiências, indagações e elaborações. A obra reúne experiências da gestão do SUS na Secretaria Estadual de Saúde do Rio Grande do Sul, no período de 2011 a 2014, tecidas pelas mãos de gestores e profissionais, tanto da rede de atenção e cuidado ao usuário, quanto da rede de apoio e educação permanente desses trabalhadores. Este livro registra invenções e produções realizadas, a partir do apoio institucional na Atenção Básica de Saúde, no campo da gestão e da produção de cuidados com populações invisíveis e/ou estigmatizadas. Demonstra a consolidação da equipe na condução da atenção básica e registra em múltiplas experiências as implicações éticas e políticas dos trabalhadores com um cuidado em liberdade e acolhedor, bem como sua aposta radical na potência de vida dos humanos.

El tratamiento de la cervicalgia con la terapia Su-Jok / Su-Jok therapy for cervicalgia treatment

Introducción: alrededor del 10% de la población adulta sufre, en algún momento de su vida, de cervicalgia. La columna cervical mantiene el equilibrio de la cabeza, lo que explica el aumento de la incidencia de cervicalgias, como consecuencia de posturas incorrectas, obligadas y mantenidas por un largo tiempo. Objetivo: determinar, según variables sociodemográficas y biomédicas, la eficacia de la terapia Su-Jok en el tratamiento de la cervicalgia. Métodos: se realizó un estudio cuasi experimental en la Sala de Rehabilitación del Policlínico Mario Gutiérrez Ardaya, del municipio de Holguín, en el período septiembre de 2015 a febrero de 2016. Remitidos por diferentes consultorios médicos, la muestra estuvo constituida por 30 pacientes. Se les aplicó la terapia Su-Jok, con el objetivo de eliminar los síntomas y las sensaciones dolorosas. Resultados: el sexo femenino resultó el más afectado con un 66,67% y los pacientes de 30 a 39 años alcanzaron un 50%. La actividad laboral que más pacientes afectó fue la de los cuentapropistas, con el 40%. Antes de la intervención, en el 63,33% predominaba el dolor severo. Luego de esta, el 76,67% presentó dolor ligero. El 53,33% de los pacientes mejoraron de la 5ta a la 8va sesión. Conclusiones: para la cervicalgia, la terapia Su-Jok es efectiva. En el futuro se requieren ensayos clínicos aleatorios controlados, que validen definitivamente la terapia utilizada.

Introduction: nearly 10% of adult population has a cervicalgia episode. Cervical spine keeps head balance; without it, muscular structure is forced to work harder. Cervicalgias raise is the result of long hours forced body positions. Objective: determining the effectiveness of Su-Jok therapy on cervicalgia treatment, according to biomedical and demographical variables. Methods: a quasi-experimental survey was carried out at the rehabilitation ward of "Mario Gutierrez Ardaya" clinic, at Holguín municipality, from September 2015 to February 2016. Sample was composed by 30 patients, referred to our center by their family doctors. Therapy was applied and the technique used was Su-Jok, to diminish symptoms and pain. Results: patients were 30-39 years old with 50%. Female were the most affected up to 66.67%. Self-employed patients were the most affected with 40%. Before the intervention, severe pain lead numbers with 63.33% and later, 76.67% showed light pain. The 53.33% of patients showed positive reactions from the 5th till 8th sessions. Conclusions: Su-Jok therapy is effective in cervicalgia. Controlled clinical trials are required therapy validation and usage.