Sarcopenia y fragilidad como predictores de riesgo de muerte en adultos mayores con enfermedad renal crónica en hemodiálisis / Sarcopenia and fragility as predictors of risk of death in older adults with chronic kidney disease on hemodialysis

Introducción: Fragilidad y sarcopenia son variables que podrían influir decisivamente en el exitus del paciente con enfermedad renal crónica sometido a hemodiálisis. Objetivo: Determinar el riesgo de muerte de pacientes adultos mayores con enfermedad renal crónica en hemodiálisis que cursan con sarcopenia y fragilidad. Materiales y métodos: Se realizó una búsqueda sistemática de investigaciones publicadas entre los años del 2013 al 2018, en las bases de datos de acceso abierto especializadas en ciencias de la salud: Google Académico, Ebsco, PubMed, Redalyc, Scielo y Lilacs. Resultados: Luego de la búsqueda realizada, se recopilaron nueve estudios internacionales y un estudio nacional. No se ubicaron estudios locales. Conclusión: Sarcopenia y fragilidad se asocian con la peor condición nutricional y clínica, así como con el peor pronóstico en el paciente adulto mayor sometido a hemodiálisis. (AU)

Introduction: Fragility and sarcopenia could decisively influence the exitus of patients with chronic kidney disease undergoing hemodialysis. Objective: To determine the risk of death of elderly patients with chronic kidney disease on hemodialysis who present with sarcopenia and frailty. Materials and methods: A systematic search of research published between 2013 and 2018 was carried out in open access databases specializing in health sciences: Google Scholar, Ebsco, PubMed, Redalyc, Scielo and Lilacs. Results: After the search, nine international studies and one national study were compiled. No local studies were located. Conclusions: Sarcopenia and fragility are associated with a worse nutritional and clinical condition, as well as a worse prognosis in the elderly patient undergoing hemodialysis. (AU)

Effects of coenzyme Qi0 on bone microstructure and myofibril structure induced by D-galactose in male mice / 中国药理学通报

; Aim To observe the effects of CoQ10 on bone microstructure and myofibril structure induced by D-galactose in male mice. Methods Forty male mice were randomly divided into control group, model group, calcitriol group and CoQ10 group, in which drugs were given for 12 weeks. At the end of the experiment, the mice were sacrificed and the femurs were taken for micro-CT and biomechanics analysis. The gastrocnemius muscle was taken for transmission electron microscope examination. Results Compared with control group, the maximum load and stiffness of femur in model group significantly decreased (P < 0. 01). The micro-CT parameters showed that Conn. D and BMD markedly decreased (P < 0. 05), while Tb. Sp evidently increased (P <0. 05). In model group, the gastrocnemius muscle fibrils parameters showed that the length of sarcomere, I-band, H-zone, M-line and Z-line significantly increased (P < 0. 01), while the length of overlapped actin and myosin filaments significantly decreased (P < 0. 01) . Compared with model group, the maximum load, Conn. D., BMD and Tb. Th of femur in coenzyme Q 1 0 group markedly increased (P < 0. 05), while SMI and Tb. Sp significantly decreased (P < 0 . 01) . Moreover, I-band, H-zone, M-line and Z-line were significantly shortened (P < 0 . 01) . Conclusion Coenzyme Q10 can improve bone microstructure damage and the contractility of gastrocnemius muscle in male mice induced by D-galactose.