ABSTRACT
OBJECTIVE: To evaluate the myocardial protective effect of the major active extracts from Salvia miltiorrhiza Bunge(SM), and clarify their different contributions in myocardial protection. METHODS: Using rat aortic rings and cardiomyocyte hypoxia-reoxygenation injury(HRI) model, experiments of SM about four active fractions, include the total tanshinones, the mixture of total salvianolic acids and glycoproteins, the total salvianolic acides, and the glycoproteins were evaluated on myocardial protection. RESULTS: The vasodilator experimental results showed that the total salvianolic acides had the strongest effect and the percentage of vasodilatation was (55.67 ± 3.09)%. The experimental of myocardial cells protection showed that the total tanshinones had the strongest protective effect on myocardial cells, and compared with model group, it had significant protective effect on HRI cells. CONCLUSION: The tanshinones and salvianolic acids in SM have myocardial protective effect, but they have different pathways and contributions, which speculates that they may have a synergistic effect in myocardial protection.