ABSTRACT
Objective To explore the application and nursing care of patients with severe burn patients with scar skin treated by ultrasound-guided PICC catheter placement. Methods Twelve patients with burn area of more than 95% were treated with intravenous catheter placement of PICC under the condition of scar hyperplasia skin with the help of ecg. Results Ten patients in elbow basilic vein catheterization by PICC disposable puncture, 1 cases of catheter in the right upper arm of the basilic vein into vascular sheath scar after guidewire dilating the skin in place leading to vascular sheath damaged anterior guidewire failed in bending catheter, to your left arm to venous catheter success, 1 cases of catheter for initial puncture puncture into the insufficient experience in successful puncture needle when the guide wire back because of scar skin relaxation will not needle guide wire fixing the wire with a lead to two times of puncture, 12 cases of catheter tip position by X-ray showed in the superior vena cava under 1/3, indwelling time ranged from-11 months of March, in the retention period without related complications. Conclusions It is feasible and advantageous for the application of PICC catheter in the treatment of severe burn patients with scar skin.
ABSTRACT
Objective To explore the application and nursing care of patients with severe burn patients with scar skin treated by ultrasound-guided PICC catheter placement. Methods Twelve patients with burn area of more than 95% were treated with intravenous catheter placement of PICC under the condition of scar hyperplasia skin with the help of ecg. Results Ten patients in elbow basilic vein catheterization by PICC disposable puncture, 1 cases of catheter in the right upper arm of the basilic vein into vascular sheath scar after guidewire dilating the skin in place leading to vascular sheath damaged anterior guidewire failed in bending catheter, to your left arm to venous catheter success, 1 cases of catheter for initial puncture puncture into the insufficient experience in successful puncture needle when the guide wire back because of scar skin relaxation will not needle guide wire fixing the wire with a lead to two times of puncture, 12 cases of catheter tip position by X-ray showed in the superior vena cava under 1/3, indwelling time ranged from-11 months of March, in the retention period without related complications. Conclusions It is feasible and advantageous for the application of PICC catheter in the treatment of severe burn patients with scar skin.
ABSTRACT
Objective To compare the effects of chemical penetration enhancers and negative electret in promoting percutaneous penetrationof 5-fluorouracil (5-FU) through rat scar and dorsal skin in vitro, so as to lay a foundation for preparing delayed-release 5-FU electret transdermal patch. Methods The in vitro transdermal behaviors of 5-FU through rat scar and dorsal skin under the actions of 1 % azone, 10% ethyl oleate, —1 000 V electret, —1 500 V electret and —2 000 V electret were studied using improved Franze diffusion cell and high performance liquid chromatography (HPLC). Results (1) Both 1% azone and 10% ethyl oleate promoted the penetration of 5-FU through rat scar and dorsal skin, with the promoting effect of 10% ethyl oleate being better than that of 1% azone. (2) Although the transdermal behaviors of 5-FU were similar through scar skin and dorsal skin at the presence of chemical enhancers, the cumulative penetration amount through the scar skinwas less than that through the dorsal skin. (3) The negative electrets used in this study had satisfactory penetration promoting effect, with the promoting effect from strong to weak being —2 000 V electret > — 1 500 V electret > — 1 000 V electret Moreover, the scar skin also had less cumulative penetration amount of 5-FU than that of the dorsal skin under the action of electrets. Conclusion Both the chemical enhancers and electrets can enhance the transdermal delivery of 5-FU. 10% ethyl oleate and — 2 000 V electret have the best enhancing effect on 5-FU transdermal delivery and can be considered for preparation of 5-FU electret transdermal patch.
ABSTRACT
Objective To observe the changes of MMP-1 and TIMP-1 expression in the pathological scar tissue after scar-skin replantation and to explore the mechanism of treating pathological scars with scar-skin replantation through a rabbit ear model.Methods Rabbit ears were used to establish the hypertrophic scar animal model in this study.Specimens were taken for three times:normal skin,hypertrophic scar and scar-skin replantion separately.We then performed HE staining,Masson staining and immunohistochemical staining to observe the expression of MMP-1 and TIMP-1 in these three groups of specimens.Results The expression of both MMP-1 and TIMP-1 significantly increased in the hypertrophic scar tissue after scar-skin replantation compared with the control group (P＜0.01).The expression of MMP-1 increased more significantly than that of TIMP-1 (P＜0.01).Conclusions The mechanism of scar-skin replantation's effect in the treatment for hypertrophic scar is relevant to the imbalance in the interaction between MMP-1 and TIMP-1 in the scar tissue.