ABSTRACT
Objective:To probe the therapeutic effect and adverse reaction of Wendan Decoction in combination with Clozapine for treatment of schizophrenia.Methods:Three groups were set up in the study,30 cases in each.The group Ⅰ were treated with Wendan Decoction,group Ⅱ with Wendan decoction plus Clozapine,and the control group with Clozapine.Positive and negative symptom scale(PANSS)and treatment emergent symptom scale(TESS)were used for evaluation of the therapeutic effect and adverse reaction.Results:The markedly effective rate was 70% and the effective rate was 30% in group Ⅱ,36.6% and 50% in the group Ⅰ,and 43.6% and 56.4% in the control group respectively.The adverse reactions in group Ⅰ and group Ⅱ were less than those in the control group.Conclusion:Wendan Decoction has a definite therapeutic effect on schizophrenia and the combined treatment has better therapeutic effect with high safety.It can improve symptoms and reduce the dosage of antipsychotics and the incidence of EPS.