ABSTRACT
A 58-year-old female, a known diabetic and hypertensive, presented with left-sided swelling on the anterior aspect of the neck of 1-year duration, which was rapidly increasing in size for the past 6 months. She was on Eltroxin for hypothyroidism for the past 1 year. Computed tomography study of the neck showed a nodule in the left lobe of thyroid which on fine-needle aspiration was suspicious for malignancy. Total thyroidectomy with left posterolateral lymph node dissection was done. Histopathological examination showed sclerosing mucoepidermoid carcinoma with eosinophilia (SMECE) of the thyroid gland with lymph node metastasis. SMECE of the thyroid was initially thought to be a low-grade malignancy with indolent clinical behavior. However, our case showed extra thyroidal spread with lymph node metastasis, necessitating adjuvant therapy for our patient. Such aggressive behavior has been noted in few earlier case reports also.
ABSTRACT
Sclerosing mucoepidermoid carcinoma with eosinophilia (SMECE) of the thyroid gland is a very rare carcinoma. We herein report on a case of SMECE with metastasis to bilateral lateral neck nodes, esophagus, and trachea. A 72-year-old woman presented with a neck mass found incidentally during a medical check-up. She had a history of cerebral stroke without sequelae 20 years ago and was taking aspirin regularly. The neck mass was confirmed as papillary thyroid carcinoma by fine needle aspiration biopsy. The patient underwent bilateral total thyroidectomy with central compartment and bilateral compartment lateral neck dissection. The right recurrent laryngeal nerve was sacrificed due to tumor invasion. The trachea wall and esophagus were also invaded by the cancer. Histologically, the tumor showed dense fibrohyaline stroma and a goblet cell, nested islands of squamoid cells, and marked stromal eosinophilia with perineural invasion and lymphovascular invasion, confirming the diagnosis of SMECE. After radiation therapy for three months, distant metastasis to the liver, lung, and bone were found on PET-CT. This case appears to be more aggressive than previously reported cases.
Subject(s)
Aged , Female , Humans , Aspirin , Biopsy , Biopsy, Fine-Needle , Carcinoma, Mucoepidermoid , Diagnosis , Eosinophilia , Esophagus , Goblet Cells , Islands , Liver , Lung , Neck , Neck Dissection , Neoplasm Metastasis , Recurrent Laryngeal Nerve , Stroke , Thyroid Gland , Thyroid Neoplasms , Thyroidectomy , TracheaABSTRACT
Mucoepidermoid carcinoma is the most common malignant salivary gland neoplasm. Its sclerosing morphologic variant, however, is an extremely rare entity. Only 15 cases have been reported in the English literature. We report a case of a sclerosing mucoepidermoid carcinoma in the left parotid gland with a review of literature. A fifty seven-year-old female patient presented with left parotid mass. Fine needle aspiration biopsy reported a parotid gland tumor, predominantly benign cystic condition, and the differential diagnosis included benign lymphoepithelial cyst and Warthin' tumor. Left superficial parotidectomy was performed. Histologically, a well demarcated mass (2.2x1.5x1.0 cm) was composed of a central sclerosis with a few tumor nests and a peripheral lymphoid hyperplasia. The lumen of the tumor glands is filled with mucin stained with mucicarmine. Finally, it was diagnosed as sclerosing mucoepidermoid carcinoma.