ABSTRACT
Interference with quorum sensing(QS)represents an antivirulence strategy with a significant promise for the treatment of bacterial infections and a new approach to restoring antibiotic tolerance.Over the past two decades,a novel series of studies have reported that quorum quenching approaches and the discovery of quorum sensing inhibitors(QSIs)have a strong impact on the discovery of anti-infective drugs against various types of bacteria.The discovery of QSI was demonstrated to be an appropriate strategy to expand the anti-infective therapeutic approaches to complement classical antibiotics and antimicrobial agents.For the discovery of QSIs,diverse approaches exist and develop in-step with the scale of screening as well as specific QS systems.This review highlights the latest findings in strategies and methodologies for QSI screening,involving activity-based screening with bioassays,chemical methods to seek bacterial QS pathways for QSI discovery,virtual screening for QSI screening,and other potential tools for interpreting QS signaling,which are innovative routes for future efforts to discover additional QSIs to combat bacterial infections.
ABSTRACT
The incidence and mortality of colorectal cancer are increasing yearly in China. Early diagnosis of colorectal cancer and advanced adenoma is an effective means to reduce the risk of cancer-related morbidity and mortality. Many studies have explored the value of stool, blood, genetic, and visualization-based diagnostic modalities and early screening strategies for the detection of colorectal cancer. There are differences in diagnostic performance, screening participation rates, and applicability among these different diagnostic methods. The quality of colonoscopy and participation rate in population for screening are key factors affecting the early diagnostic rate. The development of appropriate early screening and diagnostic strategies based on regional differences in economic, social, and health resources can lead to a better cost-effectiveness.