ABSTRACT
Objective: To investigate the chemical constituents of the leaves of Hydrangea macrophylla. Methods: The chemical constituents were separated and purified by various isolation methods (silica gel, ODS, and HPLC column chromatography), and their structures were determined by the analysis of spectral data (1H-NMR, 13C-NMR, and MS). Results: Eleven compounds were obtained and elucidated as following: secologanin ethyl methyl acetal (1), secologanin dimethyl acetal (2), secoxyloganin (3), 7-deoxyloganic acid (4), loganic acid (5), 8-epi-loganin (6), loganin (7), 7-dehydrologanin (8), sweroside (9), epi-vogeloside (10), and vogeloside (11). Conclusion: Compound 1 is a new compound, named as macrophyoside. Compounds 3 and 8 are isolated for the first time from the plants of Hydrangea Linn.