ABSTRACT
Background: Improved survival seen in Acute Lymphoblastic Leukemia (ALL) cases has led to increased reports of second malignant neoplasms. Case characteristics: A 12-yearold female treated for ALL using UK ALL XI protocol nine years back presented with progressively increasing pre-auricular swelling. Observation: Investigations revealed it to be a Mucoepidermoid carcinoma. Message: Mucoepidermoid carcinoma should be a differential in any parotid swelling of treated case of pediatric ALL.
ABSTRACT
Malignant salivary gland tumors only represent 0.08% of all childhood tumors and mucoepidermoid carcinoma (MEC) is the most common histologic type. Although there are many reports describing second malignant neoplasm (SMN) in patients treated for childhood cancer, salivary gland tumors rarely appears. In Korea, there has been no report about MEC that developed in children as a SMN. We report a MEC in a 4 years and 8 months old female child that developed after completing treatment for yolk sac tumor of lower abdomen. The primary tumor presented with metastasis at the time of diagnosis, and therefore, the child underwent high-dose chemotherapy with autologous peripheral blood stem cell transplantation along with surgery and radiotherapy. Three years and five months after completing treatment, MEC developed in her submandibular gland. She was treated with surgery and radiotherapy and is in disease free state for 5 months at the time of this writing.
Subject(s)
Child , Female , Humans , Abdomen , Carcinoma, Mucoepidermoid , Diagnosis , Drug Therapy , Endodermal Sinus Tumor , Korea , Neoplasm Metastasis , Peripheral Blood Stem Cell Transplantation , Radiotherapy , Salivary Gland Neoplasms , Salivary Glands , Submandibular Gland , WritingABSTRACT
Malignant salivary gland tumors only represent 0.08% of all childhood tumors and mucoepidermoid carcinoma (MEC) is the most common histologic type. Although there are many reports describing second malignant neoplasm (SMN) in patients treated for childhood cancer, salivary gland tumors rarely appears. In Korea, there has been no report about MEC that developed in children as a SMN. We report a MEC in a 4 years and 8 months old female child that developed after completing treatment for yolk sac tumor of lower abdomen. The primary tumor presented with metastasis at the time of diagnosis, and therefore, the child underwent high-dose chemotherapy with autologous peripheral blood stem cell transplantation along with surgery and radiotherapy. Three years and five months after completing treatment, MEC developed in her submandibular gland. She was treated with surgery and radiotherapy and is in disease free state for 5 months at the time of this writing.
Subject(s)
Child , Female , Humans , Abdomen , Carcinoma, Mucoepidermoid , Diagnosis , Drug Therapy , Endodermal Sinus Tumor , Korea , Neoplasm Metastasis , Peripheral Blood Stem Cell Transplantation , Radiotherapy , Salivary Gland Neoplasms , Salivary Glands , Submandibular Gland , WritingABSTRACT
No abstract available.
Subject(s)
Neuroblastoma , Precursor Cell Lymphoblastic Leukemia-LymphomaABSTRACT
Hodgkin's disease, manifested as a second malignant neoplasm in acute lymphoblastic leukemia, rarely occurs, with seventeen cases reported including this cases. We presented the clinical and pathological features of a nine-year-old male child with acute lymphoblastic leukemia in remission. He had cervical lymph node involvement 22 months after the diagnosis of leukemia as an initial presentation of Hodgkin's disease of mixed cellularity. A brief review of related literatures was also done.