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Objective:To investigate the association between serum lipid levels and inflammatory indicators in patients with primary open angle glaucoma (POAG).Methods:A case-control study was conducted.A total of 86 POAG subjects were collected as a POAG group at Joint Shantou International Eye Center of Shantou University and the Chinese University of Hong Kong from January 2016 to March 2022.Meanwhile, 86 with age-related cataract only, matched at age, sex and body mass index were collected as a control group.The intraocular pressure (IOP) and the mean defect of visual field (MD) were measured by Goldmann tonometer and Humphrey field analyzer, respectively.Human peripheral blood samples collected from subjects for serum lipid levels, including total cholesterol, total triglycerides, high density lipoprotein (HDL), and low density lipoprotein (LDL), were analyzed using an automated hematology analyzer and inflammatory markers including C-reactive protein, white blood cells (WBC), neutrophils, lymphocytes, monocytes, were analyzed using an automated biochemical analyzer.Indicators with statistically significant differences between the two groups were selected as independent variables, and multiple logistic regression analysis was used to determine the risk factors for POAG.Correlations between risk factors and ocular parameters (IOP and MD) were assessed using Pearson correlation analysis.This study adhered to the Declaration of Helsinki.The study protocol was approved by the Ethics Committee of Joint Shantou International Eye Center of Shantou University and the Chinese University of Hong Kong (No.EC20210313[2]-P03). Written informed consent was obtained from each patient before any medical examination.Results:The HDL was (1.59±0.42)mmol/L in the POAG group, which was significantly lower than (1.76±0.50)mmol/L in the control group ( t=2.435, P=0.016). The LDL was (3.34±0.66)mmol/L in the POAG group, which was significantly higher than (3.08±0.71)mmol/L in the control group ( t=2.520, P=0.013). The WBC was (6.91±1.60)×10 9/L in the POAG group, which was significantly higher than (6.11±1.29)×10 9/L in the control group ( t=3.619, P<0.001). Multiple logistic regression analysis showed that high serum LDL level ( P=0.039, OR=2.354, 95% CI: 1.105-5.303) and high WBC level ( P=0.044, OR=1.310, 95% CI: 1.007-1.703) were risk factors for POAG.Pearson correlation analysis showed that the serum LDL and WBC levels of POAG patients were moderately positively associated with IOP ( r=0.610, P<0.001; r=0.358, P=0.001). LDL level was moderately negatively associated with MD ( r=-0.496, P<0.001). WBC level was weakly negatively associated with MD ( r=-0.235, P=0.030). Conclusions:The elevated peripheral blood LDL and WBC levels are risk factors for POAG onset.The elevated LDL and WBC levels are positively correlated with IOP and negatively correlated with MD in POAG patients.
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Objective: To explore the dynamic changes in serum lipid levels and nutritional status during BCMA-CAR-T-cell therapy in patients with refractory or relapsed multiple myeloma (R/R MM) based on LEGEND-2. Methods: The data of patients with R/R MM who underwent BCMA-CAR-T therapy at our hospital between March 30, 2016, and February 6, 2018, were retrospectively collected. Serum lipid levels, controlled nutritional status (CONUT) score, and other clinical indicators at different time points before and after CAR-T-cell infusion were compared and analyzed. The best cut-off value was determined by using the receiver operator characteristic (ROC) curve. The patients were divided into high-CONUT score (>6.5 points, malnutrition group) and low-CONUT score groups (≤6.5 points, good nutrition group), comparing the progression-free survival (PFS) and total survival (OS) of the two groups using Kaplan-Meier survival analysis. Results: Before the infusion of CAR-T-cells, excluding triglycerides (TG), patients' serum lipid levels were lower than normal on average. At 8-14 d after CAR-T-cell infusion, serum albumin (ALB), total cholesterol (TC), high-density lipoprotein (HDL), low-density lipoprotein (LDL), and apolipoprotein A1 (Apo A1) levels dropped to the minimum, whereas CONUT scores reached the maximum. In addition to TG, apolipoprotein B (Apo B) levels increased compared with baseline. After CAR-T-cell therapy, the patients' serum lipid levels significantly increased with well-improved nutritional status. Spearman's related analysis showed that TC, HDL, and ApoA1 levels after CAR-T-cell injection were significantly negatively correlated with the grade of cytokine-release syndrome (CRS) (r=-0.548, P=0.003; r=-0.444, P=0.020; r=-0.589, P=0.001). Furthermore, survival analysis indicated that the CONUT score was unrelated to PFS, and the median OS of patients with R/R MM in the high-CONUT score group was shorter than that in the low-CONUT score group (P=0.046) . Conclusions: During CAR-T-cell therapy, hypolipidemia and poor nutritional status were aggravated, which is possibly related to CRS. The patients' serum lipid levels and nutritional status were significantly improved after CAR-T-cell treatment. The CONUT score affected the median OS in patients treated with CAR-T-cells. Therefore, specific screening and intervention for nutritional status in patients receiving CAR-T-cell therapy are required.
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Humans , Multiple Myeloma/drug therapy , Nutritional Status , Retrospective Studies , Receptors, Chimeric Antigen/therapeutic use , B-Cell Maturation Antigen/therapeutic use , Cell- and Tissue-Based Therapy , Lipids/therapeutic useABSTRACT
OBJECTIVE: To evaluate the association between ABCB1 C3435T polymorphism and statins effectiveness among Chinese population. METHODS: Databases including PubMed, Web of Scien, Cochrance Library, CNKI, WanFang Data and VIP were searched to retrieve the relevant references from the start to August 2016. A quality assessment was performed using the Methodological Index for Non-Randomized Studies(MINORS)criteria. Meta-analysis, sensitivity analysis(RevMan 5.3)were all done. RESULTS: A total of 4 studies were included for final Meta-analysis, involving 630 participants. The efficacy was evaluated by the change in TC (total cholesterol), TG(triglyceride), HDL-C(high density lipoprotein-cholesterol), and LDL-C(low density lipoprotein-cholesterol) after statin treatment. The pooled MDs were assessed for the dominant genetic model (CT+TT vs.CC), recessive genetic model (TT vs. CC+CT) and homozygote comparison (TT vs. CC).Overall, there was no statistically significant association for the four genetic models of statins effectiveness. CONCLUSION: There is no association between ABCB1 C3435T polymorphism and statins effectiveness among Chinese population.
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Objective To detect the changes of serum lipid levels in diabetic peripheral neuropathy patients,investigate the relationship between ApoB and HOMA-IRI and diabetic peripheral neuropathy.Methods One hundred and eighty-two patients with type 2 diabetes mellitus admitted to the medical department of Xuanwu Hospital Capital Medical University from January 2015 to August 2016 were enrolled in this study.All patients underwent EMG detection,the MCV of bilateral median nerve,tibial nerve and common peroneal nerve,and the SCV of median nerve,ulnar nerve and sural nerve.According to the detection results and symptoms and signs,the subjects were divided into type 2 diabetic peripheral neuropathy group (DPN,86 cases) and type 2 diabetic non peripheral neuropathy group (NDPN,96 cases).The general demographic data of the two groups was recorded,including TC,TG,HDL-C,LDL-C,FBG,HaBlc,FINS,UA,UAE and HOMA-IRI,to analyze the relationship between the nerve conduction velocity in type 2 diabetes patients with peripheral neuropathy and HDL-C,LDL-C,FINS,HbAlc,ApoB,HOMA-IRI.Results The course of disease in patients with type 2 diabetic peripheral neuropathy ((9.53 + 2.38) years,UAE (22.24) mg/L) was higher than that in patients with type 2 diabetic non peripheral neuropathy ((6.37 + 1.59) years and UAE (9.83) mg/L);FINS and HOMA-IRI levels in the DPN group were lower than those in the NDPN group ((16.33±2.33) vs.(35.16±5.02),4.94 vs.15.27,t=10.629,4.459,31.842,3.128,P<0.05);the level of TG,LDL-C and ApoB in patients with type 2 diabetic peripheral neuropathy was higher than those in patients with type 2diabetic non peripheral neuropathy,and the difference was statistically significant (P<0.05);the disorder of lipid metabolism in the DPN group was serious,whose occurrence rate was higher compared with the NDPN group (P<0.05);the MCV of median nerve was negatively correlated with ApoB (r=-0.278,P=0.041),SCV was positively correlated with HDL-C (r=0.425,P=0.002);MCV of tibial nerve was positively correlated with HDL-C (r=0.335,P=0.031),SCV of ulnar nerve was positively correlated with HDL-C (r=0.425,P=0.004) and FINS (r=0.387,P=0.006),negatively correlated with HOMA-IRI (r=-0.405,P=0.008);sural nerve SCV was positively correlated with HDLD-C (r=0.532,P=0.001),and HbAlc (r=-0.383,P=0.005),negatively correlated with LDL-C (r=-0.361,P=0.018).Conclusion Nerve conduction velocities in patients with type 2 diabetic peripheral neuropathy were associated with HDL-C,LDL-C,FINS,HbAlc,ApoB,and HOMA-IRI.
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Objective ToevaluatetherelationshipbetweentypeIIdiabetes,hyperlipidlevelandcarotidartery arthrosclerosisbyultrasonography.Methods Atotalof150retiredofficerswereselected,ofwhich63diabeticpatients were divided into case group while 87 subjects free of diabetes were divided into control group.Blood laboratory examination wasconductedandthemanifestationofcarotidarterywasexaminedbyultrasonography.Results TCH,TG,LDLand ApoB of case group were significantly higher than those in control group (P<0.05 ).The intimamedia thickness (IMT)of carotid artery in case group was increased significantly (P<0.05 ).Moreover,arteries narrowing and plaque were more than those in control group (both P <0.05 ).T peak velocity in carotid artery and internal carotid were of statistical significance between two groups (P<0.01 ).Furthermore,multiple linear regression analysis considering the degree of carotid artery arthrosclerosis and serum lipid showed that multiple correlation coefficient of case group was 0.870 (P<0.01)and0.902(P<0.01)ofcontrolgroup.Conclusion Hyperlipidemiamayhavethepromoteeffectontheformation of arteriosclerosis plaque and ultrasonography could be one of the effective methods to detect early vessel lesion of diabetic patients.
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Determine the pituitary thyroid gland axis function abnormalities and relate it with serum lipid level.We enrolled 313 elderly people from UB and Orkhon aimag. Serum total TSH, T3, T4 hormones, low –density lipoprotein, high-density lipoprotein, total cholesterol and triglyceride level were defined by ELISA and fully automatic analyzer. All analyses were conducted with the use of SPSS 19.0, MS Excel 2007 program in which mean variables, One way Anova test and bivariate correlations are included.A total of 313 elder subjects, male 29.4%, female 70.6% and mean age was 71.8±9.8. Pituitary thyroid hormone abnormalities were detected mostly in females (p=0.027), thyroid hormone decrease was noticed in 70-79 age. In all groups serum triglyceride level as in normal range but it was significantly high (p=0.027) in hypothyroid group. Triglyceride level was negatively correlated with total T4 (p<0.01), positively correlated with T3 (p<0.01).Thyroid hormone decrease increases serum lipid especially triglyceride level. Furthermore it increases atherosclerosis risk factor to elderly people thus affects the quality of life.
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OBJECTIVES: We investigated a correlation of cognitive function, depression, suicidal idea and serum lipid levels in Korean elderly over 60 years old to find risk factors of deprssion and cognitive decline. METHODS: 834 persons participated in this study. Clinical evaluation was done at a point by using Mini-Mental State Examination in the Korean version of CERAD assessment packet(MMSE-KC). We also evaluated 165 persons that agreed to our exact examination for Geriatric Depression Scale(GDS), Scale for Suicidal Ideation(SSI), Hachinski Ischemic Score and serum lipid profile. Correlation analysis was used to evaluate correlation among serum lipid levels, MMSE-KC and SSI. One-way ANOVA was used for comparison of serum lipid levels and cognitive function, depression and SSI. We did a post-hoc analysis. RESULTS: Depression and suicidal ideation were related with cognitive impairment in Korean elderly over 60 years old. Those who have more severe cognitive impairment and depressive symptom, have higher Hachinski ischemic score. We can see high HDL cholesterol levels only in the normal control group. Low total, HDL, LDL cholesterol were related with depression. CONCLUSION: There was high prevalence of depression in the Korean elderly over 60 years old and low serum lipid level was related with severity of depression and high suicidal ideation. In the normal control group, we can see high HDL cholesterol levels. To confirm this result, we need well-designed and wide range study.
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Aged , Humans , Cholesterol, HDL , Cholesterol, LDL , Depression , Prevalence , Risk Factors , Suicidal IdeationABSTRACT
OBJECTIVE:To observe the clinical efficacy of Yiqi tongmai decoction for coronary artery disease and angina pectoris and its intervention effect on patients'serum lipid level.METHODS: A total of 96 patients with coronary artery disease and angina pectoris were randomly assigned to two groups: 48(trial group) were treated with Yiqi tongmai decoction one dose daily for 4 weeks,and another 48(control group) with Guan-Xin-Ⅱ Decoction one dose daily for 4 weeks.RESULTS:The efficacy in angina pectoris and EKG in the trial group showed a significantly better improvement than in control group(P
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Objective To explore the relationship between fatty liver and body mass index (BMI), serum lipid levels in aging population. Method 748 of retired people (≥45 years) were studied. All participants accepted liver B -mode Ultrasonography examination, height, weight and blood lipid detection. The relationship between Fatty Liver and BMI, serum lipid levels were analyzed. Results The detection rate of Fatter Liver in male and female was 61.8% and 44.6% separately. The detection rate of Fatter Liver was 53.4% in the aging group (45~59 years), while the rate was 51.0% in elderly group (≥60 years). Compared to the 23.07 kg / m2 and 1.58 mmol/L in group without fatty liver, the BMI and serum triglyceride was 26.77 kg / m2 and 2.13 mmol / L in the group suffered the Fatter Lever. There existed statistically significant differences of Body Mass Index and serum Triglyceride level between the group with and without fatty liver (P
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This study was performed to investigate the relationship between obesity, health-related lifestyle, and dietary intake and serum lipid level in 96 male university students. Health-related lifestyle factors were obtained from questionnaires. Dietary intakes were evaluated with one-day 24-hr recall and two-day dietary record. Anthoropometric data were recorded and serum cholesterol and triacylglycerol concentrations were measured. 21.9%, 36.5%, 36.5%, and 6.2% of the subjects had levels beyond the normal range in serum total cholesterol(TC), HDL-cholesterol(HDL-C), LDL-cholesterol(LDL-C), and triacyglycerol respectively, and 57.3% of the subjects had more than one hyperlipidemic factor. TC was correlated positively with BMI(p<0.01), waist length(p<0.05), hip length(p<0.05), and the amount of smoking(p<0.05). HDL-C was correlated negatively with BMI(p<0.05) and hip lenghth(p<0.05). LTD-C was correlated positively with BMI(p<0.01), water length(p<0.05), hip length(p<0.01), and coffee consumption(p<0.05). TG was correlated positively with waist length(p<0.01), waist-to-hip ratio(p<0.05), and amount of smoking(p<0.01) and negatively correlated with frequence of exercise(p<0.05). Among nutrient intakes, only the ratio of protein to energy was correlated negatively with TC(p<0.05). Logistic regression analysis revealed that BMI, waist length, hip length, waist-to-hip ratio, and amount of cigarette smoking were associated with an increased risk of hyper-TC. BMI, waist length, and hip length were associated with an increased risk of hypo-HDL-C. BMI and coffee consumption were associated with an increased risk of hyper-LDL-C. Amount of cigarette smoking was associated with an increased risk of hyper-TG. In conclusion, a high prevalence of hyperlipidemia in subjects was observed. Also obesity, smoking, and coffee consumption were observed to be highly with the risk of hyperlipidemia in subjects. These findings imply that these factors should be primarily considered in planing the nutrition education program for the prevention of cardiovascular disease in male university students.
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Humans , Male , Cardiovascular Diseases , Cholesterol , Coffee , Diet Records , Education , Hip , Hyperlipidemias , Life Style , Logistic Models , Obesity , Prevalence , Reference Values , Smoke , Smoking , Triglycerides , Waist-Hip Ratio , Water , Surveys and QuestionnairesABSTRACT
OBJECTIVES: Many studies have demonstrated that suicide is related to low serum cholesterol level, whereas conflicting results have also reported. The aims of the present study are to determine whether suicidal attempters have low lipid concentration and to identify the relationship between suicidal attempt severity and serum lipid levels. METHODS: Subjects were 50 suicidal attempters who visited the emergency room in Korea University Medical Center between July 1998 and June 1999. All subjects had been interviewed by psychiatrist and evaluated with Risk-rescue rating, HDRS and BPRS. They were diagnosed as major depressive disorder (n=29), personality disorder (n=19), and schizophrenia (n=2). Serum lipid levels in 50 suicidal attempters were compared with those in 50 nonsuicidal psychiatric inpatients corresponding to the age, sex and diagnosis of the suicidal attempters. We also examined the Spearman's rank correl-ations between the serum lipid levels and risk-rescue score. RESULTS: The serum total cholesterol level (t=-3.29, p=.001), total lipid level (t=-2.62, p=.01), and LDL level (t=-2.64, p=.011) in suicidal attempters were significantly lower compared with non-suicidal controls. In major depressive patients, total cholesterol level, total lipid level, and LDL level in suicidal attempters were significantly lower than those of nonsuicidal controls. In personality disorder patients, however, only serum total cholesterol level was significantly lower. Risk-rescue rating score was negatively correlated with serum total cholesterol level (t=.-293, p=.039), and positively corre-lated with BPRS (t=.544, p< 001), and HDRS (t=.488, p=.001). CONCLUSION: The lipid levels in suicidal attempter were significantly lower. Suicidal attempt severity was also significantly correlated with serum total cholesterol level. These findings suggest that low serum cholesterol should be related with severe violent suicidal attempt.
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Humans , Academic Medical Centers , Cholesterol , Depressive Disorder, Major , Diagnosis , Emergency Service, Hospital , Inpatients , Korea , Personality Disorders , Psychiatry , Schizophrenia , SuicideABSTRACT
BACKGROUND: It has been reported that hypercholesterolemia is associated with coronary heart disease and that alcohol intake has influence on the lipid metabolism. This study was conducted to evaluate the relations between alcohol intake and serum lipid level. METHODS: We reviewed 906 subjects who had visited for routine checkup at family practice of Hanil hospital and then excluded 130 subjects with DM, renal disease, thyroid disease, hepatic disease or drug administration which might have influence on serum lipids. From the remaining 776 subjects, we obtained the amount and the frequency of alcohol drinking during the previous 2 weeks and the duration of alcohol intake, using a formed questionnaire. The alcohol dependence score was recorded by the National Alcoholism Screening Test. The serum lipids such as total cholesterol, triglyceride, and HDL-cholesterol were tested by enzyme method and the obesity index was obtained by Broca's method. These data were analyzed by SAS/PC program RESULTS: The total number of subjects was 776. Of those, 67.7%(n=525) were male and 32.3%(n= 251) females. The mean age of subjects was 50.5 years(range 15 to 77 years). The distribution according to the obesity index was as follows ; underweight group 7.1%, normal-weight group 38.1%, overweight group 31.6%, obesity group 23.2%. The number of the drinkers was 382(49.2%) in males and 7 (0.9%) in females. The mean serum lipid level were compared and analyzed among the groups. The results were as follows ; the total cholesterol and triglyceride levels were higher in males and the HDL-cholesterol levels was higher in female. The total cholesterol and triglyceride levels increased with age and obesity index, the HDL-cholesterol level decreased with obesity index. In the relationship between alcohol intake and serum lipid levels in males, the geometric mean of triglyceride level was higher among all the variables of alcohol intake, and that of HDL-cholesterol level increased with the amount and the frequency of alcohol intake. The results of multiple regression analysis associated with age, obesity index, the amount and the frequency of alcohol intake in males were as follows ; the triglyceride level was positively associated with the amount of alcohol intake, and the HDL-cholesterol level was positively associated with the frequency of akohol intake. CONCLUSIONS: The effects of age, sex and the obesity index on the serum lipid level are remarkable, and in males, alcohol intake increases triglycaride and HDL-cholesterol levels. Further study is needed to find out about whether alcohol intake have influences on coronary heart disease according to serum lipid levels.
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Female , Humans , Male , Alcohol Drinking , Alcoholism , Cholesterol , Coronary Disease , Family Practice , Hypercholesterolemia , Lipid Metabolism , Mass Screening , Obesity , Overweight , Thinness , Thyroid Diseases , Triglycerides , Surveys and QuestionnairesABSTRACT
The purpose of this study was to investigate the effect of food habits on blood components level(blood glucose, uric acid, hemoglobin, some lipids levels) and health condition in Taejon. The study was conducted with 250 subjects (male 130, female120) who cisited in a general hospital from May to June in 1997. Questionaires were used for food habits. The data were analyzed by using chi-square-test, t-test, ANOVA and multiple range test. Reuults were summerized s follow ; mean of Broca Index were 110.0+/-13.7% in male, 110.6+/-16.6% in female. Mean values of systolic blood pressure and diastolic blood pressure were 130.9+/-17.6mmHg, 76.2+/-12.6mmHg, respectively. The systolic blood pressure was significantly higher in man than woman, Mean serum total cholesterol, LDL-cholesterol, and HDL-cholesterol and triglyceride levels were 202.8+/-0.2, 121.1+/-5.5, 50.3+/-2.9, 157.1+/-12.6mg/dl, repectively. Triglyceride level was significantly higher in man than woman. But HDL-cholesterol was significantly lower in man than woman. And also, the value of LPH and AI were higher in man. So Man has more risk of atherogenesis than woman. Mean values of blood sugar, uric acid and hemoglobin was 102.7+/-.36mg/dl and 14.1+/-.56g/dl were higher in man than woman except blood sugar. Food habit of woman were better than it of man. The levels of education and income did not affect to food habit score. The most problem of habits were intake od salty food and lack of exercise. The intake of nutrients were higher as food habit score was higher. Intakes of energy, Ca, vitamin A and vitamin B1 were lower htan RDa's of nutrients in bad food habit group. This result did not show that blood components level and health condition were significantly different by food habits. But Broca Index and triglyceride levels were higher in bad food habit group than other groups, but not statistically significant. By this result, it is more needed food habit education to man and yong people. The education of food habits will include the real methods of weight control, low intak of salt and exercise to bad food habit group.