ABSTRACT
OBJECTIVE: To observe the effect of transcutaneous electrical acupoint stimulation (TEAS) of different acupoint combinations on postoperative nausea and vomiting (PONV) and serum motilin (MTL) content in patients undergoing laparoscopic surgery, so as to provide evidence for clinical selection of suitable acupoint compatibility. METHODS: A total of 140 patients undergoing elective laparoscopic surgery were randomly divided into general anesthesia (GA) control, TG2 ［Neiguan (PC6) + Hegu (LI4)］, TG3 ［PC6 + LI4 + Zusanli (ST36)］, and TG4 ［PC6 + LI4 + ST36 + Sanyinjiao (SP6)］ groups, with 35 cases in each group. Patients of the TG2, TG3 and TG4 groups received TEAS (2 Hz/100 Hz, 3-8 mA) of the above mentioned acupoint (bilateral) groups for 30 min before the induction of anesthesia until the end of the operation. Patients of the GA control group received intravenous injection of Midazolam, Sufentanil, Propofol, Rocuronium Bromide, etc. The blood sample (4 mL) from the right median cubital vein was collected at the time of patient's entry, 12 and 24 h after surgery, respectively, for measuring MTL concentration by enzyme-linked immunosorbent assay. The incidence of early and late PONV and changes of PONV degree within 24 h after surgery were recorded. RESULTS: The serum MTL concentrations were significantly decreased at 12 h after surgery in all the 4 groups (P<0.05), and decreased at 24 h after surgery in GA and TG2 groups vs their own pre-surgery (P < 0.05), and considerably higher at both 12 and 24 h after surgery in the TG2, TG3 and TG4 groups than in the GA control group (P<0.05), and also evidently higher in the TG3 and TG4 groups than in the TG2 group (P<0.05). The incidence of PONV was significantly lower in the TG2, TG3 and TG4 groups than in the GA control group in the early and late periods (except TG2 group) of surgery (P<0.05). The number of patients with PONV grade Ⅰ was significantly larger in the TG2, TG3 and TG4 groups than in the GA control group at 24 h after surgery (P<0.05), suggesting a mild PONV in more patients undergoing TEAS. CONCLUSION: TEAS has a preventive effect on PONV in patients undergoing laparoscopic surgery, which may be related to its effect in reducing serum MTL concentration. The preventive effect of TEAS of PC6 + LI4 + ST36 and PC6 +LI4 + ST36 + SP6 is similar and better than TG2 (two acupoints) group.
ABSTRACT
Objective To observe the effect of acupuncture plus Chinese medication on the therapeutic efficacy and digestive function in treating patients with functional dyspepsia (FD). Method A retrospective analysis was carried out by targeting 68 FD patients admitted during August 2015 and August 2017. According to the treatment protocol the patients received, they were divided into an observation group and a control group. The control group (33 cases) received Chinese medication, and the observation group (35 cases) was intervened by acupuncture plus Chinese medication. The two groups were compared in terms of clinical efficacy, and post-treatment changes in dyspepsia symptom score, gastric emptying, and the levels of motilin and neuropeptide in serum. Result The total effective rate in the observation group (85.7％) was higher than that in the control group (63.6％), and the difference was statistically significant (P<0.05); before treatment, there were no significant differences between the two groups in the scores of bloating discomfort, early satiation, upper abdominal pain, and upper abdominal burning sensation (P>0.05), while the scores of the dyspepsia symptoms mentioned above were significantly lower in the observation group than in the control group after treatment (P<0.05); there was no significant difference in gastric emptying between the two groups before treatment (P>0.05), while the gastric emptying evaluation was better in the observation group than in the control group after treatment (P<0.05); the between-group differences in the serum levels of motilin and neuropeptide were statistically insignificant before treatment (P>0.05), while the levels of motilin and neuropeptide in serum of the observation group were significantly higher than those in the control group after treatment (P<0.05). Conclusion Acupuncture plus Chinese medication can effectively increase the levels of motilin and neuropeptide in serum, boost gastric emptying, and improve dyspepsia symptoms and gastrointestinal motility in treating FD.
ABSTRACT
Objective: To study the effects of Sijunzi Dripping Pill (SDP) on gastrointestinal motility of mice. Methods: The diarrhea and swimming model of mice was made by Rhei Radix et Rhizoma-induced spleen deficiency. The intestinal transit, gastric emptying test, serum motilin (MTL), vasoactive intestinal peptide (VIP), and substance P (SP) were chosen to observe the effects of high-, mid-, and low-dose SDP on stomach movements, and the water extractive of Sijunzi Decoction was used as positive control. Results: Compared with the control group, the gastric emptying rate in the gastrointestinal motility group was significantly decreased, the intestinal propulsion rate was obviously increased, the levels of MTL, prostaglandin E2 (PGE2), and SP were increased (P < 0.05), while the level of VIP was decreased (P < 0.05). Compared with the model group, SDP could decrease the intestinal transit rate, whereas increase the gastric emptying rate and the level of MTL (P < 0.05); The high-dose SDP could decrease the level of PGE2 (P < 0.05) and the low-dose SDP could decrease the level of VIP (P < 0.05); Each group had no significant effect on SP. Conclusion: SDP has the good effect on increasing the gastrointestinal motility of mice, and its function may partly relate to the regulation of the levels of MTL and VIP as well as PGE2. © 2014 Tianjin Press of Chinese Herbal Medicines.