Antidiabetic and antihyperlipidemic effects of Dillenia indica (L.) leaves extract / Efeitos antidiabético e anti-hiperlipidêmico de extratos de folhas de Dillenia (L. )

The present study was carried out to evaluate antidiabetic and antihyperlipidemic effects of Dillenia indica methanolic leaves extracts in streptozotocin induced diabetic Wistar rats by administering graded oral doses (250 and 500 mg/kg body weight) for 21 days. The extract showed significant antidiabetic activity (p<0.001). Furthermore, the decreased body weight of rats was significantly improved after extract treatments. Daily oral treatment with the extract for 21 days to diabetic rats, also resulted in significant reduction in serum cholesterol, triglycerides and serum transaminase levels but HDL-cholesterol level was found to be improved (p<0.001) as compared to the diabetic control group. The extract treatment also showed to enhance serum insulin level in diabetic rats as compared to the diabetic control group. In conclusion, D. indica leaf extract might be useful for diabetes mellitus management and other abnormalities associated with this metabolic disorder.

Realizou-se o presente estudo para avaliar os efeitos antidiabético e anti-hiperlipidêmico de extratos metanólicos de folhas de Dillenia indica em ratos wistar com diabetes induzido por estreptozotocina por meio da administração de doses orais (250 e 500 mg/kg de peso corporal) por 21 dias. O extrato mostrou atividade antidiabética significativa (p<0,001). Além disso, a diminuição do peso corporal dos ratos foi significativamente melhorada após o tratamento com os extratos. O tratamento com doses orais do extrato por 21 dias aos ratos diabéticos também resultou em redução significativa do colesterol, triglicerídios e níveis de transaminase séricos, mas o nível de HDL-colesterol foi melhorado (p<0,001), quando comparado ao grupo controle diabético. O tratamento com extrato também mostrou aumento do nível sérico de insulina em ratos diabéticos comparativamente ao grupo controle diabético. Em conclusão, o extrato de folha de D. indica poderia ser útil para o controle do diabetes mellitus e de outras anormalidades associadas a essa disfunção metabólica.

Pretreatment with a low dose of concanavalin A attenuated the development of concanavalin A-induced hepatitis / 中国免疫学杂志

Objective:To investigate the influence of concanavalin A(Con A) pretreatment on the development of the fulminant murine hepatitis induced by an adequate dose of Con A.Methods:An adequate dose of Con A(15 ?g/g.body.wt) was injected intravenously into C57BL/6 mice to provoke severe liver damage,an extensively-used murine hepatitis model.A low dose of Con A(3 ?g/g.body.wt) was administrated intravenously 12 h before injection with an adequate dose of Con A.Liver injury was evaluated by serum transaminase assay and H&E staining.Hepatic lymphocytes were analyzed by flow cytometry and the absolute amount of lymphocytes per liver was calculated.Results:Pretreatment with a low dose of Con A significantly inhibited Con A-induced liver injury.Both the percentage and the absolute number of liver CD3~+T cells in Con A-pretreated mice were lower than those of PBS-pretreated mice.The activation of liver CD3~+T cells in Con A-pretreated mice was also prominently inhibited.Conclusion:Con A pretreatment exerted the negative effect on the development of Con A-induced hepatitis,which may be result from the decreased recruitment of T cells into the liver.The underlying mechanisms are under investigation.

Chronic Toxic Effect of Herbicide Mixture on Mice Hepatic Function and Ultrastructure / 环境与健康杂志

Objective To observe the chronic hepatotoxicity of the commonly used herbicide mixture in the mice. Methods Low doses herbicide mixture diluted in mice drinking water. The parameters related to hepatic function and ultrastructural changes of the hepatocytes were examined after 18 weeks and 24 weeks of treatment. Results No changes was observed in every parameter after 18 weeks of treatment compared with the control group. After 24-week of treatment, the electron microscope revealed the ultrastructural changes in the hepatocytes, rough endoplasmic reticulum showed dilatation, mitochondria showed matrix muddy with distortion and disappearance of inner crista and the serum transaminase were higher than those in the control group(P

A study of serum transaminase level and it's correlation with several symptoms in children with HRV gastroenteritis

The retrospective study was taken to study the serum transaminase level and it's correlation with several symptoms in human rotavirus gastroenteritis. 494 children, who admitted to the Department of Pediatrics in Dae Dong Hospital from January 1991 to December 1991 with chief complaints of waterdy diarrhea were included in studies. The 1st stool specimen on admission was tested for rotavirus Ag by ELLSA method. and than serum transaminase were checked. The results are as follows: 1) The peak incidence being between 6 months to 2 years in both group, but higher incidence was noted in Non-HRV group. Males are more common than females by ratio of about 2:1. 2) The major symptoms in order of frequency was diarrhea>dehydration>vomiting>coughing>fever in HRV group, diarrhea>dehydration=vomiting>fever>coughing in Non-HRV group. The incidence of dehydration and coughing in HRV group were higher than in Non-HRV group. 3) AST & ALT elevation above the normal value were 83.2% (213/256), 52.0% (133/256) in HRV group and 45.3% (116/238), 22.3% (57/238) in Non-HRV group. AST & ALT were significantly increased in HRV group than Non-HRV group (AST: p0.05, Non-HRV group: p>0.05). 6) Duration of diarrhea for 4-5 days & 1-3 days were relatively more common in HRV group than Non-HRV group. The frequency were 36.3% (93/256) in HRV group and 34.9% (83/268) in Non-HRV group. The degree of diarrhea were not correlated with serum transaminase level at each group (HRV group: p>0.05, Non-HRV group: p>0.05). 7) No fever or duration of fever for 1-2 days were relatively more common in both group. The frequency were 39.9% (102/256), 37.5% (96/256) in HRV group and 38.2% (91/238), 42.5% (101/238) in Non-HRV group. The degree of fever was not correlated with serum transaminase level in HRV group, but correlated with Non-HRV group (HRV group: p>0.05, Non-HRV group: p<0.05).

A clinical study on Duchenne muscular dystrophy

No abstract available.

A Study of Serum Ferritin Levels in Patients with Acute Infectious Hepatitis

Serum ferritin, iron, and total iron binding capacity were measured in 47 patients who were admitted to Hanyang University Hospital under the diagnosis of acute infectious hepatitis(excluding HBsAg positive patients) from September 1980 to March 1981. At the same time, serum transminase were estimated as indicator of liver function. Then we evaluated the relationship between serum ferritin, iron, and iron binding capacity and transaminase. The results were as followings: 1. Among 47 cases, 25 cases were male and 22 cases were female. Age distribution was from 1 year and 10 months to 14 years old. 2. Serum transaminase levels, GOT were from 51 unit to 1,010 unit and mean value was 644.8+/-315.7unit, and GPT were from 139 unit to 825 unit and mean value was 662.3+/-231.6 unit. 3. Serum iron levels were from 33microgram/dl to 264microgram/dl and mean value was 103.6+/-42.7microgram/dl, total iron binding capacities were from 267microgram/dl to 588microgram/dl, and mean value was 393.5+/-80.6microgram/dl. Serum ferritin levels were from 12ng/ml to 1,420ng/ml and mean value was 184.3+/-251.7ng/ml. 4. There was no correlation between serum iron and serum transaminase. 5. There was no correlation between total iron binding capacity and serum transaminase. 6. There was no correlation between serum ferritin and serum transaminase.

Effects of Rifampin(RMP) on Liver Function in Tuberculous Children

To evaluate the hepatotoxicity of RMP in tuberculous children during treatment, liver function tests were performed regularly in 40 children who visited or admitted in Chonnam University Medical School Hospital and Mok-po Children's Tuberculosis Hospital from January 1979 to August 1980. The subjects were divided into three groups according to the administered regimens which were INH+EMB or PAS, INH+RMP(10??15mg/kg) and INH+RMP(16??20)mg/kg respectively. The mean observation period wart 16 weeks and the obtained results were compared between each group which were summerized as follows; 1) Significant increase of serum transaminase activity was noted in the patients who received RMP. 2) Increase of serum transaminase activity developed within 4 weeks after the administration of RMP and the mean value was highest in the second week. 3) The incidence of increased serum transaminase activity was slightly higher in the female subjects. 4) No relationship could be found between the increase of serum transaminase activity and the dosage of RMP. 5) Serum alkaline phosphatase showed no significant difference among three groups. 6) Serum bilirubin concentration was not increased in all subjects.