ABSTRACT
This article described the main classification of severe drug eruption and its clinical mani-festations,summarized the treatment principle of severe drug eruption,including stopping sensitization drugs, hormone therapy,support treatment,anti-infection treatment,etc,and summarized nursing methods of severe drug eruption,including removal of allergens,preventing infection,condition observation,skin care,mucosal care,nutritional supporting,psychological care and health education to provide reference and guidance for the treatment and nursing of severe drug eruption.
ABSTRACT
Severe drug eruption is the most common skin drug adverse reaction in clinic. Immune‐mediated adverse drug reactions occur commonly in clinical practice and include mild,self‐limited cutaneous eruptions, IgE‐mediated hypersensitivity, and severe cutaneous adverse drug reactions. Severe cutaneous adverse drug reactions represent an uncommon but potentially life‐threatening form of delayed T cell‐mediated reaction. The spectrum of illness ranges from acute generalized exanthematous pustulosis to drug reaction with eosinophilia with systemic symptoms,to the most severe form of illness,Stevens‐Johnson syndrome and toxic epidermal necrolysis. Drug‐induced exfoliative dermatitis may be one of the manifestations of eosinophilia with systemic symptoms. Typical clinical manifestations,medication history,relevant physical examinations and related auxiliary examinations of patients are helpful to the early diagnosis of the disease. This article introduced in detail the research progress of acute generalized eruptive pustulosis and exfoliative dermatitis eruption.
ABSTRACT
This article described the main classification of severe drug eruption and its clinical manifestations, summarized the treatment principle of severe drug eruption, including stopping sensitization drugs, hormone therapy, support treatment, anti-infection treatment, etc, and summarized nursing methods of severe drug eruption, including removal of allergens, preventing infection, condition observation, skin care, mucosal care, nutritional supporting, psychological care and health education to provide reference and guidance for the treatment and nursing of severe drug eruption.
ABSTRACT
Objective:To explore the clinical characteristics of various types of severe drug eruption and common sensitized drugs,and to provide clinical references for reducing the incidence of severe drug eruption.Methods:The clinical data regarding 126 cases of severe drug eruption were analyzed retrospectively from June 2009 to May 2017 in Xiangya Hospital,Central South University.Results:In the 126 cases of severe drug eruption,the distribution of men and women ratio was 1∶1.38.The length of stay was (12.7±9.8) d.The most common type was Steven-Johnson syndrome;the most dangerous type was drug-induced bullosa epidermolysis,The most common sensitized drug category in these patients was antibiotics;the most common single sensitizing drug was carbamazepine,following by allopurinol.Conclusion:Severe drug eruption occurs mostly in young and middle-aged people.Steven-Johnson syndrome is the most common type;drug hypersensitive syndrome has the longest length of hospital course.Mortality rate of drug-induced bullosa epidermolysis is the highest.Timely stop using of allergens,early using glucocorticoids,and timely combination of non-glucocorticoids treatment (such as intravenous immunogloblin,plasma exchange and hemodialysis),can improve the efficacy and reduce the complications and mortality.
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Objective:To investigate the effect of medron impact treatment on severe drug eruption.Method:The 45 patients were divided into 2 groups at random.The treatment group was treated by medron,and the control group was treated by corson.Result:The treatment group was better than the control group in shortening the time of therapy obviously(P0.05).Conclusion:Medron impact treatment has good effect on severe drug eruption.It can control the state of the illness in short time,and shorten the course of disease.