ABSTRACT
Ovarian fibroma is the most common sex cord stromal tumour of ovary accounting to 1-5% of all ovarian tumours. Minor sex cord elements in ovarian fibroma are a rare entity occupying less than 10% of tumour area. To the best of our knowledge only 20 cases has been reported till date. This case is presented because of its rarity. Authors reported a case of fibrothecoma with minor sex cord elements in a 70yr old postmenopausal women who presented with postmenopausal bleeding with abdominal mass.
ABSTRACT
Background: Ovarian tumours are a heterogeneous neoplasm with a varied clinical, morphological and histological feature. Increasing mortality rate due to ovarian cancers has been reported in recent years. Ovarian tumours in post-menopausal females have high risk of malignancy and it has a very poor outcome. The aim and objective of this study was to determine clinical and histopathological spectrum and the frequency and age distribution of various ovarian tumors.Methods: It is a retrospective observational study of patients with ovarian tumors in the department of obstetrics and gynecology, SGRRI of Medical Health & Sciences and Hospital from January 2016 to December 2017 in a total number of 86 patients. All specimens were sent to pathology department and categorised according to WHO hispathological classification.Results: Out of 86 cases examined, 64 cases were benign (74.4%), 3 cases were borderline (3.4%) and 19 cases were malignant (22.2%). Majority of the ovarian tumors (73.4%) were seen in the age group of 20 to 50 years. Most commonly encountered benign ovarian tumour was serous cystadenoma (58.1%). Surface epithelial tumors were the commonest tumors (64%) followed by germ cell tumors (29%).Conclusions: A variety of benign and malignant tumours of ovary were reported in this study. Early diagnosis and appropriate treatment of ovarian neoplasms favour the good prognosis. Most common benign tumour encountered in this study was serous cystadenoma.
ABSTRACT
A sex cord-stromal tumour is one that is composed of granulosa cells, theca cells, Sertoli cells, Leydig cells and fibroblasts of stromal origin, singly or in various combinations. A pseudopapillary pattern has been described recently in granulosa cell tumours. This was seen in both juvenile and adult types. Pseudopapillae develop as a secondary or degenerative phenomenon lacking true stromal cores. The distinction of a granulosa cell tumour from a surface epithelial carcinoma can be aided by the use of Epithelial Membrane Antigen (EMA) which is positive in carcinomas and Inhibin and Calretinin is positive in granulosa cell tumours. A negative inhibin on immunohistochemistry does not exclude a diagnosis of granulosa cell tumour.The study by Irving et al (2006) emphasizes the distinction of a group of mitotically active, cytologically bland, cellular fibromatous tumours from fibrosarcomas. These tumours show a mean of 6.7 Mitotic figure (MF)/10 HPF with a range of 4 to !9 MF/ I 0 HPF. Luteinized thecomas occur in younger women than typical the comas, the mean age being 46 years. A distinct variant of luteinized the coma is one that is associated with sclerosing peritonitis. Microcystic stromal tumour is a newly recognized entity. Twelve types of this non-functioning, neoplasm have been described, all occurring in adults. Sertoli cell tumours are rare in their pure form. They often present with oestrogenic manifestations in young women. Occasional cases are seen in the Peutz-Jeghers syndrome.