ABSTRACT
Objective@#To summarize and discuss the clinical effect of Shiquan Dabu Decoction combined with nitroglycerin in the treatment of heart failure after acute myocardial infarction.@*Methods@#From January 2016 to June 2017, 110 patients with heart failure after acute myocardial infarction admitted to the Department of Cardiology of Lishui Hospital of Traditional Chinese Medicine were selected as study objects.The patients were randomly divided into observation group and control group according to the digital table, with 55 cases in each group.The control group was treated with routine nitroglycerin therapy, while the observation group was treated with routine nitroglycerin therapy combined with Shiquan Dabu Decoction.The therapeutic effect of the two groups after one week of treatment was observed.@*Results@#The total effective rate in the observation group was 92.73%, which was significantly higher than that of the control group(78.18%), and the difference between the two groups was statistically significant(χ2=4.681, P<0.05). The HR level of the observation group[(82.5±6.5)times/min] was significantly lower than that of the control group[(102.6±3.9)times/min](t=19.655, P<0.01). The levels of SBP[(116.5±6.4)mmHg]and SpO2[(95.2±1.6)%] in the observation group were significantly higher than those in the control group[(108.8±5.2)mmHg, (92.5±1.2)%], there were statistically significant differences between the two groups(t=6.925, 10.012, all P<0.01). The incidence of adverse reaction in the observation group was 10.91%, which was higher than that in the control group(3.64%), but there was no statistically significant difference (χ2=2.157, P>0.05).@*Conclusion@#For patients with heart failure after acute myocardial infarction, the combination of traditional Chinese medicine Shiquan Dabu Decoction in clinical routine treatment has better effect and is worthy of popularizing.
ABSTRACT
Objective To summarize and discuss the clinical effect of Shiquan Dabu Decoction combined with nitroglycerin in the treatment of heart failure after acute myocardial infarction .Methods From January 2016 to June 2017,110 patients with heart failure after acute myocardial infarction admitted to the Department of Cardiology of Lishui Hospital of Traditional Chinese Medicine were selected as study objects .The patients were randomly divided into observation group and control group according to the digital table ,with 55 cases in each group.The control group was treated with routine nitroglycerin therapy ,while the observation group was treated with routine nitroglycerin therapy combined with Shiquan Dabu Decoction.The therapeutic effect of the two groups after one week of treatment was observed.Results The total effective rate in the observation group was 92.73%,which was significantly higher than that of the control group (78.18%),and the difference between the two groups was statistically significant ( χ2 ＝4.681,P＜0.05).The HR level of the observation group [(82.5 ±6.5)times／min] was significantly lower than that of the control group[(102.6 ±3.9)times／min](t＝19.655,P＜0.01).The levels of SBP[(116.5 ±6.4)mmHg] and SpO2[(95.2 ±1.6)%] in the observation group were significantly higher than those in the control group [(108.8 ± 5.2)mmHg,(92.5 ±1.2)%],there were statistically significant differences between the two groups ( t ＝6.925, 10.012,all P＜0.01).The incidence of adverse reaction in the observation group was 10.91%,which was higher than that in the control group (3.64%),but there was no statistically significant difference (χ2 ＝2.157,P＞0.05). Conclusion For patients with heart failure after acute myocardial infarction ,the combination of traditional Chinese medicine Shiquan Dabu Decoction in clinical routine treatment has better effect and is worthy of popularizing .
ABSTRACT
Objective To investigate the toxicity attenuation and efficacy potentiation effects of Shiquan Dabu Tang (SDT) on high dose chemotherapy in T739 mice with bladder carcinoma. Methods Mouse bladder carcinoma tissue was inoculated subcutaneously into T739 mice to establish tumor-beating mice model. The tumor-bearing mice were randomly divided into a CTX group (100, 200, 400 mg/Kg respectively), a SDT group (high or low dose respectively), a high-dose SDT combined with 200 mg/Kg CTX group and a control group. The body weight, diameter of tumor nodules and complete blood count were observed subsequently. Results Different doses of SDT could effectively inhibit tumor growth in mice. SDT + CTX treatment significantly prolonged the survival time of mice by 49.4±23.3 days (P<0.01, 0.05, 0.01), compared with high dose SDT treatment (17.4±5.77) days, 200 mg/kg CTX treatment (23±14.02) days and control group (11.75±2.06) days respectively. The peripheral platelet count increased more significantly in mice treated with SDT within a week as compared to mice without SDT treatment (P<0.05). The peripheral RBC count and liB concentration increased more significantly in mice treated with SDT for 2 weeks as compared to mice without SDT treatment (P<0.05). Conclusions SDT could enhance the anti-tumor effects of high dose CTX on tumor-bearing mice and reduce toxicity in its peripheral red blood cells. The results showed that SDT combined with high dose of CTX chemotherapy had toxicity attenuation and efficacy potentiation effects in tumor-beating T739 mice.
ABSTRACT
A summary of detoxcating effect of shiquan dabu tang on anti-neoplastic agents during the past 10 years in Japanese Literature shows that it could allevate digestive symptoms, relieve arrest of bone marrow, raise white blood cell count, reduce renal toxicity, and enhance immunity. Antineoplastic agents administration together with traditional Chinese medicine is considered as an alternative method which can improve efficacy and reduce adverse effects, and is worthy of further study.