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Background: Sida cordifolia Linn. and Glycyrrhiza glabra Linn. have been mentioned in Ayurvedic texts for their anti-inflammatory, antioxidant and sexual properties. After finding good results in treatment of male sexual disorders during pre-clinical studies, this clinical trial was taken up to assess the spermatogenesis action of aqueous extract of roots of these two plants.Methods: The study used qualitative criteria such as primary and secondary symptoms and quantitative investigations such as haematological investigations, hormonal analysis and semen analysis for assessing the therapeutic efficacy of research formulation through placebo controlled clinical trials on 50 males having lack of sexual desire and non-satisfactory sexual life.Results: Very high inhibition was noticed in respect of primary symptoms such as lack of libido, difficulty in ejaculation or little amount of semen, as well as secondary symptoms such as nausea, body ache, headache, indigestion, loss of appetite and general weakness in the research group. Lack of any adverse changes in haematological parameters (blood sugar, haemoglobin, ESR, RBC and WBC) and biochemical parameters (bilirubin, protein, SGPT and SGOT and ALP) indicate the non-toxic nature of research formulation. The hormonal levels registered a significant increase during clinical study in research group, especially the testosterone level (10.36%). Semen quality evaluated through sperm count, motility and morphology showed a significant improvement in research group, suggesting that administration of research drug in cases of stress-related sexual problems protected healthy cells by reduced generation of ROS and helped maintain quality parameters of spermatozoa during spermatogenesis.Conclusions: The research formulation made from roots of Sida cordifolia Linn. and Glycyrrhiza glabra Linn. showed good and significant (p<0.05) therapeutic efficacy through inhibition of primary and secondary symptoms and enhancement in hormonal and seminal parameters, validating its spermatogenesis effect without any toxic or adverse effects.
ABSTRACT
Background: Sida cordifolia Linn. is a well-known medicinal plant which exhibits anti-inflammatory, antioxidant, and sexual properties. It shows good promise in the treatment of male sexual disorders during its pre-clinical studies. Objective: The objective of the study was to assess the spermatogenesis action of aqueous extract of roots of S. cordifolia Linn. in clinical trials. Materials and Methods: The study uses qualitative criteria such as primary and secondary symptoms, and quantitative investigations such as hematological investigations, hormonal analysis, and semen analysis for assessing the therapeutic efficacy of research formulation through placebo-controlled clinical trials on 50 males having lack of sexual desire and non-satisfactory sexual life. Results: Very high inhibition was noticed in respect of primary symptoms such as lack of libido, difficulty in ejaculation or little amount of semen, as well as secondary symptoms such as nausea, body ache, headache, indigestion, loss of appetite, and general weakness in the research group. Lack of any adverse changes in hematological parameters (blood sugar, hemoglobin, ESR, RBC, and WBC) and biochemical parameters (bilirubin, protein, SGPT, SGOT, and ALP) indicates the non-toxic nature of research formulation. The hormonal levels registered a significant increase during the clinical study in research group, especially the testosterone level (8.53%). Semen quality evaluated through sperm count, motility, and morphology showed a significant improvement in research group, suggesting that administration of research drug in cases of stress-related sexual problems protected healthy cells by reduced generation of ROS and helped maintain quality parameters of spermatozoa during spermatogenesis. Conclusion: The research formulation made from roots of S. cordifolia Linn. shows good and significant (P < 0.05) therapeutic efficacy through inhibition of primary and secondary symptoms and enhancement in hormonal and seminal parameters, validating its spermatogenesis effect without any toxic or adverse effects.
ABSTRACT
The anti-inflammatory activities of Sida cordifolia leave extract were scientifically stated. However, no report has yet been published about the active component responsible for anti-inflammatory activity of Sida cordifolia leaves extract. It was intended to isolate the flavonoids from the Sida cordifolia leaves extract and investigated its anti-inflammatory efficacy. Petroleum ether and ethanol extract were extracted out from the powdered of leaves. The phytochemical study was done for both extracts. The in vitro antioxidant activity was performed on ethanol extract on different models. The column chromatography was used for the isolation of flavonoid from ethanol extract, and further anti-inflammatory potency of the isolated compound was investigated. The phytochemical study indicates flavonoids and polyphenol were present in ethanol extract. The higher antioxidant activity was observed in ethanol extract from findings of antioxidant study. The isolated flavonoids exhibited Rf value of 0.46 on solvent ratio of chloroform: methanol (1:1), which was similar to standard quercetin. The significant anti-inflammatory activity was found for isolated flavonoid against carrageenan-induced edema and cotton pellet-induced granuloma in experimental animals. The findings confirmed that the flavonoid present in the Sida cordifolia demonstrated anti-inflammatory activity.
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Arthritis is a form of joint disorder that involves inflammation of one or more joints. It is very common condition especially in women and older people. Ayurveda has contributed a lot for the management of arthritic conditions. The plant Bala, identified as Sida cordifolia Linn. is a widely used drug in many of the Ayurvedic formulations especially in those for arthritic conditions. Kashaya (decoction) is one of the commonly prescribed preparations in Ayurveda. Present study was aimed to assess the anti-arthritic activity of Kashaya (decoction) of root of Sida cordifolia Linn. by inhibition of protein denaturation method and Inhibition of proteinase enzyme activity. Kashaya of roots of Bala was prepared as per standard procedure and was used to induce protein denaturation in Bovine serum albumin and to inhibit the activity of proteinase enzyme, trypsin. The absorbance was read by spectrophotometer to evaluate the percentage of inhibition in both the procedures. Each experiment was done in triplicates. The results were compared with standard drug Diclofenac sodium. Sida cordifolia Linn. showed dose dependent inhibitory activity and highest activity was seen in 500µg/ml concentration in both the experiments. The result showed that root of Sida cordifolia Linn. is having anti-arthritic property. Further studies can be carried out with other formulations of Bala like Choorna (powder), Swarasa (juice) etc. to compare their anti-arthritic activity. The study supports the classical use of plant Bala in various formulations in the treatment of arthritis.
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Introduction: Sida cordifolia L. (Malvaceae) is a weed about which not much is known in Colombia. This plant is used in folk medicine to treat oral mucosa, blennorrhea, asthma and bronchitis.In Brazil it finds application as an anti-inflammatory,while in Colombia its "baba" is used for treating hair loss, constipation and internal fever, among other ailments. Objectives: to quantify the saponoside content and evaluate its antioxidant and antifungal functionality. Methods: we prepared organic, aqueous and hydroalcoholic extracts from the aerial section of the plant. The saponoside material was quantified by the DNS and p-anisaldehyde methods. The most concentrated extracts were selected for antioxidant and antifungal assays. Results: it was found that Sida cordifolia, collected in Ibague-Colombia, is a good source of saponins with diverse chemical structures, mainly of steroidal nature, some of which may be hecogenin, diosgenin or a homologue. Conclusions: these factors may contribute, at least in part, to the antioxidant and antifungal functionality of Sida cordifolia L., but this capacity may be modified if these saponins act independently or together with some other metabolites of the plant such as tannins, flavonoids steroids, and alkaloids among others.
Introducción: Sida cordifolia L. (Malvaceae) es una hierba de la cual se tiene un conocimiento limitado en Colombia. Se utiliza en la medicina popular para el tratamiento de la mucosa oral, la blenorragia, el asma y la bronquitis. En Brasil encuentra aplicación como antiinflamatorio, mientras que en Colombia su "baba" se utiliza para tratar la pérdida del cabello, el estreñimiento, y la fiebre interna, entre otros padecimientos. Objetivos: cuantificar el contenido saponósido y evaluar sus propiedades antioxidantes y funcionalidad antifúngica. Métodos: se prepararon extractos orgánicos, acuosos e hidroalcohólicos de la parte aérea de la planta. El material de saponósidos se cuantificó por los métodos del DNS (dinitrosalicylic acid reagent) y de p-anisaldehído. Los extractos más concentrados se seleccionaron para los ensayos antioxidante y antifúngico. Resultados: estos mostraron que Sida cordifolia, colectada en Ibague-Colombia, es una buena fuente de saponinas con diversas estructuras químicas, principalmente de naturaleza esteroidal, algunas de las cuales pueden ser hecogenina, diosgenina o un homólogo. Conclusiones: estos factores pueden contribuir, al menos en parte, en la funcionalidad antioxidante y antifúngica de Sida cordifolia L., pero su capacidad se puede modificar si esas saponinas actúan de forma independiente o en conjunto con otros metabolitos de la planta, como taninos, esteroides flavonoides, alcaloides, entre otros.
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Se realizo la evaluacion de la actividad antibacteriana del extracto etanolico de la parte aerea de Sida cordifolia L(Malvaceae) y de las fracciones obtenidas por extraccion en condiciones diferenciales de ph empleando el metodo de microtitulacion en placa utilizando resazurina como indicador de de viavilidad celular frente a un panel constituido por 2 bacterias Gram positivos(+) y 2 Gram negativos(-).
Evaluacion of antibacterial activity of the ethanolic extract from the aerial parts of sida cordifolia L(Malvaceae) and fraction obtaineid by differential pH extraction was performed againt a panel of2Gram positivos(+) y 2Gram negativos(-)
Subject(s)
Pseudomonas aeruginosa/drug effects , Sida Plant/chemistry , Anti-Bacterial Agents/pharmacology , Anti-Bacterial Agents/chemistry , Microbial Sensitivity Tests , Plant PreparationsABSTRACT
Our world is fulfilled by various medicinal plants which are widely have been used in treatment of various diseases since ancient time. Medicinal plants still play an important role in emerging and developing countries. They also generate income to people of many Asian countries who can earn their livelihood from selling collected materials from the forest or by cultivating on their farms. Thus the medicinal plants constitute very important rational resources. In India plants have been trditionally used for human and veterinary health care needs. This reflects that medicinal plant and their products have taken an increasing demand. Herbs are staging a comeback and herbal ‘renaissance’ is happening all over the globe. The herbal products today symbolize safety in contrast to the synthetics that are regarded as unsafe to human and environment. Although herbs had been priced for their medicinal, flavoring and aromatic qualities. Malvaceae, commonly known as Bala, is an Ayurvedic medicine that is used to treat bronchial asthma, cold and flu, chills, lack of perspiration, head ache, nasal congestion, aching joints and bones, cough and wheezing, and edema. The root infusion is given in nervous and urinary diseases and also in disorders of the blood and bile. Sida cordifolia has been reported to posess analgesic, anti-inflammatory and hypoglycemic activities as well as hepatoprotective activity. Traditionally the plant Sida cordifolia (linn) syn has been used as CNS depressant, fat lose, analgesics, anti-inflammatory, hypotensive, hepatoprotectiv. Presence of ephedrine has highlighted the utility of this plant .various ayurvadic preparation of this plant used in asthma diseases, fat lose and increase energy, Oil preparation is also cure pain, swelling disorder, and Gritha cures Heart diseases. This plant has great potential to develop the Ayurvedic, modern medicine and athletic supplements by pharmaceutical industries. The present review is highlights the traditional uses, Ayurvedic preparation, chemical constituents and pharmacological properties of Sida cordifolia (linn) syn. Country Mallow.
ABSTRACT
The analysis of the antimicrobial activity of the essential oil of Sida cordifolia was evaluated with four different strains of bacteria and nine fungi. The essential oil was tested "in natura" (100 percent) and diluted from 32 until 2 percent. The microorganisms, bacteria and fungi, were spread in agar Muller-Hinton and Sabouraud dextrose, respectively. S. cordifolia showed inhibitory activity against the microorganisms tested with efficacy of 80 percent. When tested against Staphylococcus aureus, Staphyllococus epidermidis, Candida guilliermondii and Trichosporon inkin the essential oil showed the best performance.
A análise da atividade antimicrobiana do óleo essencial de Sida cordifolia foi avaliada com quatro diferentes cepas de bactérias e nove de fungos. O óleo essencial foi testado "in natura" 100 por cento e diluído de 32 até 2 por cento. Os microrganismos, bactérias e fungos, foram semeados em ágar Muller-Hinton e Sabouraud dextrose, respectivamente. S. cordifolia mostrou atividade inibitória contra os microrganismos testados com eficácia de 80 por cento. Quando testado contra Staphyllococus aureus, Staphyllococus epidermidis, Candida guilliermondii e Trichosporon inkin o óleo essencial mostrou um melhor desempenho.
ABSTRACT
PURPOSE: The use of medicinal plants for the treatment of human diseases has increased worldwide. Many of them are used by oral administration and, after absorption, may affect many organs. Therefore, this study aimed at assessing the effects of the aqueous extract of Sida cordifolia leaves, popularly known in Brazil as "malva-branca", on liver regeneration. METHODS: Twenty rats were divided into four groups: control, Sida100, Sida200 and Sida400 groups. All animals were submitted to oral administration of distilled water, 100, 200 and 400 mg/kg of the aqueous extract of Sida cordifolia, respectively. Immediately after this, they underwent 67 percent partial hepatectomy. Twenty four hours later, their livers were removed. Hepatic regeneration was assessed by immunohistochemical staining for proliferating cell nuclear antigen (PCNA) using the PC-10 monoclonal antibody. RESULTS: Sida100 and Sida200 groups disclosed higher liver regeneration indices than control group (p<0.001 and p<0.05, respectively). CONCLUSION: The aqueous extract of Sida cordifolia stimulates liver regeneration after 67 percent partial hepatectomy in rats.
INTRODUÇÃO: O uso de plantas medicinais para o tratamento de patologias humanas tem aumentado em todo mundo. Muitas delas são usadas por administração oral, e após a absorção podem afetar muitos órgãos. OBJETIVO: Esse estudo, tem como objetivo verificar o efeito do extrato aquoso de Sida cordifolia, popularmente conhecida no Brasil como "malva-branca", na regeneração hepática. MÉTODOS: Vinte ratos foram divididos em 4 grupos: controle, Sida 100, Sida 200 e Sida 400. Os animais foram submetidos a administração oral de água destilada, 100, 200 e 400 mg/kg de extrato aquoso de Sida cordifolia, respectivamente. Imediatamente após, foi realizada hepatectomia parcial 67 por cento. Vinte quatro horas após, os fígados foram removidos. A regeneração hepática foi avaliada por imunohistoquímica (PCNA), usando o anticorpo monoclonal PC-10. RESULTADOS: Os grupos Sida100 e Sida200 mostraram índices de regeneração hepática maiores que o grupo controle (p<0.001 e p<0.05, respectivamente). CONCLUSÃO: O extrato aquoso de Sida cordifolia estimula a regeneração hepática após hepatectomia parcial a 67 por cento em ratos.