ABSTRACT
The aim of the present study was to assess the antipyretic activity of Siddha herbo-mineral formulation Surangusa Parpam at the dose level of 15mg/kg and 35mg/kg body weight, orally, in brewer yeast induced fever model Wistar rats. Fever was induced by subcutaneous injection of 10ml/kg of 20% w/v aqueous suspension of brewer’s yeast into the nape of the rat's neck. After eighteen hours feverish animals were treated with Surangusa Parpam 15mg/kg and 35mg/kg body weight, orally, and rectal temperatures were evaluated at 0, 1, 2 and 3 hours post-treatment by inserting a well-lubricated bulb of the clinical thermometer. Surangusa Parpam showed a significant decrease in the elevated body temperature of rats that remained sustained throughout the tested time points from 1 to 3 hours in the used model. 35mg/kg body weight dose level showed significant inhibition of elevated body temperature when compared with the standard control. These results indicate that the Antipyretic activity of Surangusa Parpam and in addition to its well-established anti-inflammatory activity possesses significant antihistamine activity that may be beneficial in symptomatic relief when it is used in the therapy of allergic and inflammatory disorders.
ABSTRACT
Siddhars said about various diseases and the treatment methods with herbs, minerals and animal products. In Siddha literatures viral fevers can be compared to Vatha Kapha Suram and therefore decoction for this Suram is taken from classical Siddha text book and the ingredients are searched for pharmacological activity and toxicity study from 118 published journal papers from Pubmed, Scopus, Google Scholar, Research Gate and Science Direct. Collected data is entered in MS excel and analysed using RFC score. All together there are 51 pharmacological activities are published for these nine ingredients. In which Anti-inflammatory has RFC=1, other properties like antipyretic, anti-tussive, bronchodialator, anti-asthmatic, analgesic, neuro-regenerative, neuroprotective, anti-diarrhoeal, anti-emetic, neuroprotective, analgesic, sedative has more than 0.55 RFC score. More than this cardioprotective, renoprotective, hepatoprotective, and other protective properties are present in more than 50% of ingredients. In toxicity studies no toxic effects are seen in in vivo studies for the ingredients The Suvai, Thanmai, Pirivu, in Siddha aspect, of these ingredients can highly reduces Vatha and Kapha disorders. Therefore, the decoction shows significant pharmacological activity for the sign and symptoms of viral infections.
ABSTRACT
Padarthamarai is the fungal skin infections and are categorised under Kutta Rogam (Padarthamarai -Pundareega Kutam). Many siddha drugs are prescribed for these diseases among them, Pataic Cankãran is exclusively mentioned for these disease as an internal and external medicine in Siddha literature - Siddha Vaidya Thirattu. Two different preparations are mentioned under Pataic Cankãran and differences observed in the ingredients as in Pataic Cankãran I Ankol (Alangium salvifolium (L.f.) Wang.), Marukkarai (Catunaregam spinosa (Thunb.) Tirvengadumia) and Elumitchai (Citrus aurantifolia (Christm.) Swingle), where as in Pataic Cankãran II, Thagarai (Senna tora (L.) Roxb.), Erruku (Calotropis procera (Ait.) R.Br.) are used. Even though Pataic Cankãran is mentioned in literature exclusively for dermatophytosis which is no longer in uses; Clinical study and standardisation of this drug have not been done so far, but In-vitro anti-dermatophytotic activities of the individual ingredient of these formulations have already been proved. The present review article aimed to document the biological, pharmacological and therapeutic applications such as anti-microbial, anti-bacterial and anti-inflammatory activities of individual ingredients used in Pataic Cankãran I with reference to skin diseases. This study will help to understand the need of research study on this ancient Siddha formulation.