Bladder Metastasis: An Unusual Presentation of Stomach Cancer.

Linitus plastica of the stomach is a type of gastric carcinoma usually diagnosed at a late stage due to a lack of early pathognomonic symptoms. A diagnosis is usually by endoscopy and biopsy, however, lack of mucosal involvement leads to false negative reports. Over 50% of patients present with distant metastasis. Metastasis to bladder is rare and synchronous detection of bladder metastasis along with the primary tumor has only been reported in 5 cases in English literature. We present a case where clinical suspicion of a gastric malignancy was made in retrospect after biopsy of bladder tumor confirmed metastasis from a gastrointestinal primary.

A Case of Primary Signet Ring Cell Adenocarcinoma of the Uterine Cervix / 대한산부인과학회지

Signet ring cell adenocarcinoma of the cervix is most commonly considered to be metastatic in origin. We describe one case of primary signet ring cell adenocarcinoma of the cervix occuring in 49-year-old patient. The lesion was located at the posterior lip of the cervix and about 3 cm in size. This case was parametrium thickening in pelvic examination and positive for HPV type 18. CCRT (concurrent chemoradiotherapy) was done for clinical FIGO stage II B adenocarcinoma of the cervix. The patient is alive for 6month since diagnosis and disappear lesion of the cervix. A upper gastroenteroscopy, colonoscopy, cystoscopy, intravenous pyelogram, abdominal pelvic CT, PET CT, mammogram were reported negative. Therefore we concluded this case for a primary cervical origin of signet ring cell adenocarcinoma of the uterine cervix.

Two Cases of Primary Signet-Ring-Cell Adenocarcinoma of the Urinary Bladder / 대한비뇨기과학회지

Primary Signet-ring-cell adenocarcinoma of the urinary bladder is an extremely rare variant that promotes considerable interest, 21 cases reported as of 1981. Morphologically, this tumor is identical to signet-ring-cell carcinomas of the gastrointestinal tract, breast, lung and nasal cavity, and differentiation must be carried out with great care. Characteristically, primary signet-ring-cell adenocarcinoma carries a poor prognosis with early penetration of the mucosa, submucosa, and muscularis. This tumor is sessile, infiltrates early, extends locally to adjacent organs, and metastasized late. Many patients reported died of local extension with ureteral obstruction and uremia rather than wide spread metastasis. We are reporting two cases of primary signet-ring-cell adenocarcinoma of the urinary bladder treated with radical cystectomy and transurethral resection with radiotherapy, which died of local extension with ureteral obstruction and uremia, with pathological findings and review of the literatures.