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BACKGROUND: Soft silicone silver ion dressing, a kind of high molecular weight organic compound prepared with Safetac technology, has the characteristics of anti-infection, good permeability and good air permeability. It can provide a good moist environment for wound healing. OBJECTIVE: To evaluate the effectiveness of soft silicone silver ion dressings in repairing deep II degree and milder burn wounds. METHODS: A computer-based retrieval of CNKI, VIP, WanFang, CBM, PubMed, Embase and Web of Science databases was performed. The randomized controlled trials concerning soft silicone silver ion dressing for repairing deep II degree and milder burn wounds were selected. The treatment group was treated with a single soft silicone silver ion dressing, or a soft silicone silver ion dressing combined with conventional treatment, or combined with other treatments. The control group was treated with conventional treatment, or other treatments, or placebo. After screening, data extraction and quality evaluation, meta-analysis was performed using Review Manager 5.3 software. RESULTS AND CONCLUSION: (1) Eleven articles were included, involving 784 patients, 381 patients in the treatment group and 403 patients in the control group. (2) The results of meta-analysis showed that the burn wound healing rate in the treatment group was higher than that in the control group [OR=11.56, 95%CI (9.60, 13.53), P < 0.000 01; OR=13.29, 95%CI (7.54, 19.04), P < 0.000 01; OR=4.10, 95%CI (2.28, 5.93), P < 0.000 1; OR=1.17, 95%CI (0.42, 1.93), P=0.002] at 7, 14 and 21 days, and the last measurement. The healing time of burn wounds in the treatment group was shorter than that in the control group [OR=-2.81, 95%CI (-3.49, -2.12), P < 0.000 01]. The degree of pain in burn wounds in the treatment group was lower than that in the control group [OR=-0.38, 95%CI (-0.53, -0.24), P < 0.000 01]. There was no significant difference in the positive rate of bacterial culture on wound surface [OR=1.16, 95%CI (0.47, 2.85), P=0.74], burn wound infection [OR=1.44, 95%CI (0.47, 4.41), P=0.52], dressing frequency [OR=-8.04, 95%CI (-18.82, 2.74), P=0.14], wound treatment cost [OR=-98.26, 95%CI (-272.91, 76.40), P=0.27] and adverse reaction [OR=0.61, 95%CI (0.31, 1.20), P=0.15] between treatment and control groups. (3) These results show that the application of soft silicone silver ion dressing on deep II degree and milder burn wounds can improve wound healing rate, shorten wound healing time and alleviate pain.
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Nowadays, antibacterial products containing silver ion are widely used in clinical wound treatment. The concentration of silver ion in products, pH value, and other factors may affect the release of silver ion and its antibacterial effects. In the treatment of clinical wound, silver ion product plays a good role in anti-infection, promoting healing and reducing medical expenses. In this paper, the related applications of silver ion products in wound surface are analyzed, and the antibacterial properties of silver ion and its therapeutic effects in wound treatment are summarized.
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Objective To explore the clinical application value and nursing experience of Urgotul parcel technology used for the treatment of surface abscess incision and drainage of the wound. Methods A total of 150 patients with surface abscess incision and drainage of the wound who received treatment in our hospital wound care room divided into A group, B group and C group (each group had 50 cases). Considering the characteristics of outpatients and the requirements of ethics, A group of patients from January to May of 2017 received the technology of Urgotul parcel alginate dressing with silver, B group of patients from June to December of 2016 received the treatment by the Mesalt and C group of patients from November 2015 to May 2016 used petrolatum gauze. After the infection control, each group received the treatment by Urgotul. Observe the difference with wound healing time, infection control time, the pain score of removing the dressings and filling of dressings, the number and the cost of wound care of patients. Results In A group, the scores of infection control time, wound healing time, the pain score of removing the dressings and filling of dressings, the number and the cost of wound care were (5.1±1.4) days, (22.9± 6.5) days, (1.3 ± 0.9) points, (1.9 ± 1.2) points, (6.6 ± 1.9) times, (603.81 ± 116.82) yuan, B group were (6.7 ±1.4) days, (24.7±7.2) days, (1.8±1.0) points, (4.1±1.4) points, (11.5±3.3) times, (736.94±203.81) yuan, and C group were (11.1 ± 2.1) days, (31.7 ± 3.8) days, (4.62 ± 1.3) points, (2.4 ± 1.1) points, (31.7 ± 3.7) times, (1617.20 ± 303.98) yuan. The difference between the three groups was statistically significant (F=30.48-931.29, all P<0.01). In infection control time, the pain score of removing the dressings, the number and the cost of wound care A group was better than B group and C group (P<0.05). The wound healing time of A group was shorter than C group (P<0.01), but was the same as B group (P>0.05). Filling of dressings the patients in A group and C group felt less pain than B group (P<0.01), and the pain scores in both A group and C group are same (P>0.05). Conclusions Urgotul parcel technology is able to control infection effectively, promote wound healing, Alleviate the pain of changing medicine, reduce the times and costs of wound care, improve patient compliance for patients with surface abscess incision and drainage of the wound. So Urgotul parcel technology has a significant role in these patients.
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Objective To study and observe the application effect of debridement adhesive combined with comfeel silver ion dressing in the treatment of wound after the total cystectomy.Methods 90 patients with total cystectomy in Cixi People's Hospital from July 2014 to June 2016 were selected as the research object, and all the patients were randomly divided into control group 45 cases and observation group 45 cases, the control group were treated with conventional treatment of postoperative wound, the observation group were treated with debridement adhesive combined with comfeel silver ion dressing on the treatment of control group, then the infection rates, degree of edema and local comfort, life quality and local microcirculation state before and after the intervention of two groups were respectively analyzed and compared .Results The infection rates of observation group were higher than those of control group, the degree of edema and local comfort, life quality and local microcirculation state after the intervention were all significantly better than those of control group, the difference was all statistically significant ( P <0.05 ).Conclusion The application effect of debridement adhesive combined with comfeel silver ion dressing in the treatment of wound after the total cystectomy is better , and it has active role for the improvement of discomfortableness and microcirculation state.
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Objective To detect the physico-chemical properties , cytotoxicity and antimicrobial activity of dressings containing Ag +.Methods The morphology of this dressing was shown by the scanning electron microscope ( SEM ) .The cytotoxicity was detected by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide(MTT) method.Using the shake flask test method , the antibacterial effect of dressings was studied .Result There was no significant difference in the water vapor transmission rate between the dressings (P>0.05).Compared with the alginate calcium dressing ,silver ion dressings had a stronger swelling rate .A higher ion concentration would lead to a much larger swelling rate and slower degradation . A lower cytotoxicity was exhibited among the dressings .The silver ion dressing had stronger bacteriostasis to Gram-positive ( G+) and Gram-negative ( G-) bacteria than the alginate calcium dressing .Conclusion The experiment has proved that the silver ion dressing has stronger antibacterial activity and lower cytotoxicity , and it is more effective for wound surface healing, with a shortened treatment course .
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Objective To compare the disinfection efficacy of different disinfectants on dental unit waterlines (DUWLs). Methods 18 sets of DUWLs were randomly divided into 4 groups,and disinfected or treated with hydrogen peroxide (H2 O2 )disinfectant,sodium hypochlorite (NaClO)disinfectant,hydrogen peroxide silver ion disinfectant(Sanosil),and distilled water (DW)respectively.Water specimens from triple syringes and high-speed handpieces were taken,bacterial count before and after disinfection were compared.Results Before disinfection,no significant differences in bacterial counts were found among four groups (all P >0.05),bacterial counts of DUWLs of all groups severely exceeded the standard(all>3 000 CFU/mL).After disinfection,except DW group,bacterial counts of DUWLs of the other groups declined dramat-ically (all <100 CFU/mL),bacterial count after disinfection were all obviously lower than before disinfection (all P <0.001 ).One week after disinfection,bacterial counts among three disinfectant groups in different time periods were statisti-cally different (triple syringes:Day1—Day5,all P <0.05;high-speed handpieces:Day2,Day3 and Day5,all P <0.05). Day3 after disinfection of triple syringes by H2 O2 and NaClO,Day4 after disinfection of high-speed handpieces by H2 O2 and NaClO,and Day5 of triple syringes and high-speed handpieces by Sanosil all exceeded the standard of Center for Disease Control and Prevention of America.One week after disinfection,bacterial counts of three disinfection groups all exceeded or approximated to that before disinfection.Conclusion Three types of disinfectants can all effectively reduce bacterial load in DUWLs.Compared with other disinfectants,Sanosil has advantage of inhibiting bacterial growth after disinfection.
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Although silver is known to be a broad-spectrum biocidal agent, the effects of this metal against Sacbrood virus have not yet been investigated. In this study, we evaluated the efficacy of silver ions against natural Korean sacbrood virus (KSBV) infection of Apis (A.) cerana. Ten KSBV-infected colonies containing A. cerana with similar strength and activity were selected from an apiary located in Bosung-gun (Korea). Among these, five colonies were randomly assigned to the treatment group that was fed sugar syrup containing 0.2 mg/L silver ions. The other colonies were assigned to the untreated control group in which bees were given syrup without the silver ions. To assess the efficacy of the silver ions, colony strength, colony activity, and the number of dead larvae per hive were measured. During the experimental period, the test group maintained its strength and activity until day 32 while those of bees in the control group decreased sharply after day 8 to 16. Survival duration of the test group was significantly longer (40 days) than that of the control group (21 days). These results strongly indicated that silver ions are effective against KSBV infection in A. cerana.
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Animals , Antiviral Agents/pharmacology , Beekeeping , Bees/virology , Ions/pharmacology , RNA Viruses/drug effects , Republic of Korea , Silver/pharmacologyABSTRACT
Objective: To study the durability of the antimicrobial effect of polymethylmethacrylate (PMMA) denture base containing silver-supported antimicrobial agents of nanometer level against Streptococcus mutans and Candida albicans in vitro. Methods:The antimicrobial PMMA resin bases with the antimicrobial agent STR-1 at concentration of 5 mg/ml were prepared. Then the samples were divided into 4 groups: positive control group, the group immersed in distilled water at 57 ℃ for 14 days, the group irradiated by ultraviolet for 8 hours, and the group irradiated by ultraviolet for 8 hours after immersed in distilled water at 57 ℃ for 14 days. Then the inhibition ratios of the 4 groups against Streptococcus mutans and Candida albicans in vitro were tested. Results:The inhibition ratios of the 4 groups against Streptococcus mutans were 99%, 96%, 98%, and 90% in turn. The inhibition ratios of the 4 groups against Candida albicans were 91%, 82%, 90%, and 80% respectively. Conclusion: The antimicrobial effect of PMMA denture base containing silver-supported antimicrobial agents STR-1 of nanometer level at concentration of 5 mg/ml against Streptococcus mutans and Candida albicans in vitro is durable.
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Objective:To study the antimicrobial effect of polymethylmethacrylate (PMMA) denture base with silver-containing antimicrobial agents of nanometer level against Streptococcus mutans and Candida albicans in vitro. Methods:Minimum inhibitory concentration (MIC) of the silver-containing antimicrobial agent against S. mutans and C. albicans was examined. According to the MIC, 4 concentrations(1,2,5 and 10 mg/ml) of the agent were selected for the preparation of antimicrobial PMMA resin base. Then, the antimicrobial effect of the resin base was examined by in vitro bacteria culture and the most probable number(MPN) counting. Results:The MICs of the agent against S. mutans and C. albicans were 0.1 mg/ml and 1 mg/ml respectively. With the agent at 1, 2, 5 and 10 mg/ml, the inhibition ratios of the base against S.mutans were 67.4%,71.3%,99.0 and 99.5% respectively, that against C. albicans were 25.8%,54.8%,90.3% and 93.0%, respectively. Conclusion:The polymethylmethacrylate resin base with silver-containing antimicrobial agent of nanometer level at 5 mg/ml has ideal antimicrobial activity against S. mutans and C. albicans.